Prostaglandin concentrations in cerebrospinal fluid of rabbits under normal and ischemic conditions

Barrett Katz, M. Sofonio, P. D. Lyden, M. D. Mitchell

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Clinical studies have demonstrated elevated levels of both arachidonic acid and prostaglandins in the cerebrospinal fluid of humans after ischemic stroke and subarachnoid hemorrhage. Such increases in free fatty acid, arachidonic acid, and prostaglandin concentrations suggest excessive production and accumulation of these substances in the ischemic brain. We used a rabbit model of ischemic infarction to examine the relation between controlled central nervous system ischemia and cerebrospinal fluid prostaglandin levels. We found that following stroke PGF(2α) and not PGD2 was the predominant prostaglandin present in the cerebrospinal fluid. PGF(2α) also underwent the largest percent increase over control prostaglandin concentations. This is similar to human and dog cerebrospinal fluid studies, which demonstrate PGF(2α) as the predominant prostaglandin following ischemic injury. The lack of PGD2 elevation under ischemic conditions may suggest that the rabbit model is more like stroke in humans than the rat or gerbil models. Our preliminary work demonstrates that it is practical to study postischemic prostaglandin changes in cerebrospinal fluid rather than in brain tissue in a rabbit model of central nervous system ischemia.

Original languageEnglish (US)
Pages (from-to)349-351
Number of pages3
JournalStroke
Volume19
Issue number3
StatePublished - 1988
Externally publishedYes

Fingerprint

Prostaglandins
Cerebrospinal Fluid
Rabbits
Prostaglandins F
Prostaglandin D2
Stroke
Arachidonic Acid
Ischemia
Central Nervous System
Gerbillinae
Brain
Subarachnoid Hemorrhage
Nonesterified Fatty Acids
Infarction
Dogs
Wounds and Injuries

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Katz, B., Sofonio, M., Lyden, P. D., & Mitchell, M. D. (1988). Prostaglandin concentrations in cerebrospinal fluid of rabbits under normal and ischemic conditions. Stroke, 19(3), 349-351.

Prostaglandin concentrations in cerebrospinal fluid of rabbits under normal and ischemic conditions. / Katz, Barrett; Sofonio, M.; Lyden, P. D.; Mitchell, M. D.

In: Stroke, Vol. 19, No. 3, 1988, p. 349-351.

Research output: Contribution to journalArticle

Katz, B, Sofonio, M, Lyden, PD & Mitchell, MD 1988, 'Prostaglandin concentrations in cerebrospinal fluid of rabbits under normal and ischemic conditions', Stroke, vol. 19, no. 3, pp. 349-351.
Katz, Barrett ; Sofonio, M. ; Lyden, P. D. ; Mitchell, M. D. / Prostaglandin concentrations in cerebrospinal fluid of rabbits under normal and ischemic conditions. In: Stroke. 1988 ; Vol. 19, No. 3. pp. 349-351.
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