Prospects of vaccines for medically important fungi. Feasibility and prospects for a vaccine to prevent cryptococcosis

Arturo Casadevall, Liise-anne Pirofski

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Cryptococcosis is a relatively common fungal disease caused by Cryptococcus neoformans that has high morbidity and mortality. Numerous studies have established the feasibility of enhancing host immunity in to C. neoformans naive immunocompetent animal models by vaccination. Several antigens have been identified that appear to be suitable vaccine candidates. Induced immune responses can mediate protection through both humoral and cellular immunity. Hence, a vaccine against cryptococcosis in humans is probably feasible but there are significant obstacles to vaccine development that range from uncertainties about the pathogenesis of infection to economic considerations.

Original languageEnglish (US)
Pages (from-to)667-680
Number of pages14
JournalMedical Mycology
Volume43
Issue number8
DOIs
StatePublished - Dec 2005

Fingerprint

Cryptococcosis
Cryptococcus neoformans
Fungi
Vaccines
vaccines
fungi
vaccine development
humoral immunity
cell-mediated immunity
morbidity
uncertainty
pathogenesis
Mycoses
immunity
animal models
vaccination
immune response
Humoral Immunity
antigens
Cellular Immunity

Keywords

  • Cryptococcosis
  • Cryptococcus neoformans
  • Vaccine development

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • veterinary(all)
  • Microbiology

Cite this

Prospects of vaccines for medically important fungi. Feasibility and prospects for a vaccine to prevent cryptococcosis. / Casadevall, Arturo; Pirofski, Liise-anne.

In: Medical Mycology, Vol. 43, No. 8, 12.2005, p. 667-680.

Research output: Contribution to journalArticle

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