Propofol reduces the incidence of vomiting after tonsillectomy in children.

S. M. Barst, A. Markowitz, Y. Yossefy, A. Abramson, Philip W. Lebowitz, R. S. Bienkowski

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We compared the effect of a propofol-based anaesthetic to an isoflurane-based anaesthetic on the incidence of postoperative vomiting in children following tonsillectomy. Thirty-nine children were enrolled in the study and randomized to receive one of the proposed anaesthetics. All patients underwent a mask induction with halothane, nitrous oxide, and oxygen. Intravenous access was established and all children received fentanyl (2-4 micrograms.kg-1) i.v., mivacurium (0.3 mg.kg-1) i.v. and acetaminophen (10-15 mg.kg-1) p.r. Following tracheal intubation, patients received either isoflurane (0.8-1.6%) or propofol (120-180 micrograms.kg-1 min-1) i.v. with nitrous oxide 70%/oxygen 30% for maintenance of anaesthesia. Vital signs were maintained within 20% of baseline. All patients were extubated in the operating room. PACU nursing staff recorded episodes of vomiting for 4-6 h prior to discharge. A telephone interview the following day was also used for data recovery. Age, sex, and duration of the procedure were not significantly different between the two study groups. Of 19 patients who received propofol, four vomited (21%); in contrast, of the 20 patients who received isoflurane, 11 vomited (55%). This difference is significant (P = 0.048 two-tailed Fisher's Exact Test). These data suggest that using propofol for anaesthesia can diminish the incidence of vomiting following tonsillectomy.

Original languageEnglish (US)
Pages (from-to)249-252
Number of pages4
JournalPaediatric Anaesthesia
Volume5
Issue number4
StatePublished - 1995

Fingerprint

Tonsillectomy
Propofol
Vomiting
Isoflurane
Incidence
Anesthetics
Nitrous Oxide
Anesthesia
Oxygen
Postoperative Nausea and Vomiting
Vital Signs
Nursing Staff
Fentanyl
Halothane
Operating Rooms
Acetaminophen
Masks
Intubation
Maintenance
Interviews

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Barst, S. M., Markowitz, A., Yossefy, Y., Abramson, A., Lebowitz, P. W., & Bienkowski, R. S. (1995). Propofol reduces the incidence of vomiting after tonsillectomy in children. Paediatric Anaesthesia, 5(4), 249-252.

Propofol reduces the incidence of vomiting after tonsillectomy in children. / Barst, S. M.; Markowitz, A.; Yossefy, Y.; Abramson, A.; Lebowitz, Philip W.; Bienkowski, R. S.

In: Paediatric Anaesthesia, Vol. 5, No. 4, 1995, p. 249-252.

Research output: Contribution to journalArticle

Barst, SM, Markowitz, A, Yossefy, Y, Abramson, A, Lebowitz, PW & Bienkowski, RS 1995, 'Propofol reduces the incidence of vomiting after tonsillectomy in children.', Paediatric Anaesthesia, vol. 5, no. 4, pp. 249-252.
Barst SM, Markowitz A, Yossefy Y, Abramson A, Lebowitz PW, Bienkowski RS. Propofol reduces the incidence of vomiting after tonsillectomy in children. Paediatric Anaesthesia. 1995;5(4):249-252.
Barst, S. M. ; Markowitz, A. ; Yossefy, Y. ; Abramson, A. ; Lebowitz, Philip W. ; Bienkowski, R. S. / Propofol reduces the incidence of vomiting after tonsillectomy in children. In: Paediatric Anaesthesia. 1995 ; Vol. 5, No. 4. pp. 249-252.
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