Abstract
Purpose: To evaluate whether the duration of gonadotropin stimulation predicts the likelihood of live birth after ART. Methods: All IVF or ICSI cycles using fresh autologous oocytes at our institution between January 2004 and December 2007 were analyzed. Results: Out of 699 cycles resulting in oocyte retrieval, 193 produced a live birth (27.6%). Women who achieved a live birth had a significantly shorter stimulation phase (11.1 vs. 11.5 days, respectively). Multivariable analysis suggested that 13 days or longer of stimulation decreased the likelihood of a live birth by 53% as compared to cycles that were 10-12 days long (odds ratio [OR] 0.47; 95% confidence interval [CI]: 0.30-0.75) after adjustment for female age, maximum historical FSH, total dose of gonadotropin received, oocytes retrieved, embryos transferred, antagonist suppression and PCOS diagnosis. Conclusions: Prolonged duration of gonadotropin stimulation is an independent negative predictor of ART success in our cohort.
Original language | English (US) |
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Pages (from-to) | 711-717 |
Number of pages | 7 |
Journal | Journal of Assisted Reproduction and Genetics |
Volume | 27 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2010 |
Keywords
- Assisted reproduction
- Gonadotropins
- IVF/ICSI outcome
- Infertility
- Ovarian stimulation
ASJC Scopus subject areas
- Reproductive Medicine
- Genetics
- Obstetrics and Gynecology
- Developmental Biology
- Genetics(clinical)