Prolonged gonadotropin stimulation is associated with decreased ART success

Meleen Chuang, Athena Zapantis, Martina Taylor, Sangita K. Jindal, Genevieve S. Neal-Perry, Harry J. Lieman, Alex Joel Polotsky

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: To evaluate whether the duration of gonadotropin stimulation predicts the likelihood of live birth after ART. Methods: All IVF or ICSI cycles using fresh autologous oocytes at our institution between January 2004 and December 2007 were analyzed. Results: Out of 699 cycles resulting in oocyte retrieval, 193 produced a live birth (27.6%). Women who achieved a live birth had a significantly shorter stimulation phase (11.1 vs. 11.5 days, respectively). Multivariable analysis suggested that 13 days or longer of stimulation decreased the likelihood of a live birth by 53% as compared to cycles that were 10-12 days long (odds ratio [OR] 0.47; 95% confidence interval [CI]: 0.30-0.75) after adjustment for female age, maximum historical FSH, total dose of gonadotropin received, oocytes retrieved, embryos transferred, antagonist suppression and PCOS diagnosis. Conclusions: Prolonged duration of gonadotropin stimulation is an independent negative predictor of ART success in our cohort.

Original languageEnglish (US)
Pages (from-to)711-717
Number of pages7
JournalJournal of Assisted Reproduction and Genetics
Volume27
Issue number12
DOIs
StatePublished - Dec 2010

Fingerprint

Live Birth
Gonadotropins
Oocytes
Oocyte Retrieval
Intracytoplasmic Sperm Injections
Embryonic Structures
Odds Ratio
Confidence Intervals

Keywords

  • Assisted reproduction
  • Gonadotropins
  • Infertility
  • IVF/ICSI outcome
  • Ovarian stimulation

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Developmental Biology
  • Genetics
  • Genetics(clinical)

Cite this

Prolonged gonadotropin stimulation is associated with decreased ART success. / Chuang, Meleen; Zapantis, Athena; Taylor, Martina; Jindal, Sangita K.; Neal-Perry, Genevieve S.; Lieman, Harry J.; Polotsky, Alex Joel.

In: Journal of Assisted Reproduction and Genetics, Vol. 27, No. 12, 12.2010, p. 711-717.

Research output: Contribution to journalArticle

Chuang, Meleen ; Zapantis, Athena ; Taylor, Martina ; Jindal, Sangita K. ; Neal-Perry, Genevieve S. ; Lieman, Harry J. ; Polotsky, Alex Joel. / Prolonged gonadotropin stimulation is associated with decreased ART success. In: Journal of Assisted Reproduction and Genetics. 2010 ; Vol. 27, No. 12. pp. 711-717.
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AU - Lieman, Harry J.

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