Prolactin as a Second Messenger for Interleukin 2

Michael B. Prystowsky, Charles V. Clevenger

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The generation of an effective immune response requires the selection and proliferation of antigen-specific lymphocytes. Activation of at least some T lymphocytes involves the sequential stimulation of cell surface receptors, including the T-cell receptor for antigen, the interleukin 2 receptor, and the prolactin receptor. Prolactin signaling in T lymphocytes appears to utilize a classical receptor-mediated kinase cascade and a novel peptide hormone activation pathway involving nuclear translocation.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalImmunoMethods
Volume5
Issue number1
DOIs
Publication statusPublished - Aug 1 1994
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Immunology

Cite this