Progress in targeting the BCL-2 family of proteins

Thomas P. Garner, Andrea Lopez, Denis E. Reyna, Adam Z. Spitz, Evripidis Gavathiotis

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

The network of protein–protein interactions among the BCL-2 protein family plays a critical role in regulating cellular commitment to mitochondrial apoptosis. Anti-apoptotic BCL-2 proteins are considered promising targets for drug discovery and exciting clinical progress has stimulated intense investigations in the broader family. Here, we discuss recent developments in small molecules targeting anti-apoptotic proteins and alternative approaches to targeting BCL-2 family interactions. These studies advance our understanding of the role of BCL-2 family proteins in physiology and disease, providing unique tools for dissecting these functions. The BCL-2 family of proteins is a prime example of targeting protein–protein interactions and further chemical biology approaches will increase opportunities for novel targeted therapies in cancer, autoimmune and aging-associated diseases.

Original languageEnglish (US)
Pages (from-to)133-142
Number of pages10
JournalCurrent Opinion in Chemical Biology
Volume39
DOIs
StatePublished - Aug 1 2017

Fingerprint

Proteins
Apoptosis Regulatory Proteins
Physiology
Drug Discovery
Aging of materials
Apoptosis
Molecules
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

Progress in targeting the BCL-2 family of proteins. / Garner, Thomas P.; Lopez, Andrea; Reyna, Denis E.; Spitz, Adam Z.; Gavathiotis, Evripidis.

In: Current Opinion in Chemical Biology, Vol. 39, 01.08.2017, p. 133-142.

Research output: Contribution to journalReview article

Garner, Thomas P. ; Lopez, Andrea ; Reyna, Denis E. ; Spitz, Adam Z. ; Gavathiotis, Evripidis. / Progress in targeting the BCL-2 family of proteins. In: Current Opinion in Chemical Biology. 2017 ; Vol. 39. pp. 133-142.
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