Progress in targeting the BCL-2 family of proteins

Thomas P. Garner, Andrea Lopez, Denis E. Reyna, Adam Z. Spitz, Evripidis Gavathiotis

Research output: Contribution to journalReview articlepeer-review

62 Scopus citations


The network of protein–protein interactions among the BCL-2 protein family plays a critical role in regulating cellular commitment to mitochondrial apoptosis. Anti-apoptotic BCL-2 proteins are considered promising targets for drug discovery and exciting clinical progress has stimulated intense investigations in the broader family. Here, we discuss recent developments in small molecules targeting anti-apoptotic proteins and alternative approaches to targeting BCL-2 family interactions. These studies advance our understanding of the role of BCL-2 family proteins in physiology and disease, providing unique tools for dissecting these functions. The BCL-2 family of proteins is a prime example of targeting protein–protein interactions and further chemical biology approaches will increase opportunities for novel targeted therapies in cancer, autoimmune and aging-associated diseases.

Original languageEnglish (US)
Pages (from-to)133-142
Number of pages10
JournalCurrent Opinion in Chemical Biology
StatePublished - Aug 2017

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry


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