Prognostic Value of Late Gadolinium Enhancement in Nonischemic Cardiomyopathy

Juan Gaztanaga, Vijayapraveena Paruchuri, Elliott Elias, Jonathan Wilner, Shahidul Islam, Simonette Sawit, Juan Viles-Gonzalez, Javier Sanz, Mario J. Garcia

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The purpose of this study was to determine the prognostic value of late gadolinium enhancement seen on cardiac magnetic resonance (CMR) imaging in patients with nonischemic cardiomyopathy (NICMP). Patients with NICMP are at increased risk for cardiovascular events and death. The presence of late gadolinium enhancement (LGE) in CMR may be associated with a poor prognosis, but its significance is still under investigation. We retrospectively studied 105 consecutive patients with NICMP and left ventricular ejection fraction (LVEF) ≤40% referred for CMR. The cohort was analyzed for the presence of LGE and left and right ventricular functional parameters. Patients were followed for the composite end point of hospitalization for congestive heart failure, appropriate implantable cardioverter-defibrillator therapy, or all-cause mortality. LGE was observed in 68% (n = 71) of the cohort. Both groups were similar in age, LVEF and LV end-diastolic volume. The LGE+ patients were more often men and had larger right ventricular volumes. At a mean follow-up of 806 ± 582 days, there were 26 patients (23 in the LGE+ group) who reached the primary end point. Event-free survival was significantly worse for the LGE+ patients. After adjusting for traditional risk factors (age, gender, and LVEF), patients with LGE had an increased risk of experiencing the primary end point (hazard ratio 4.47, 95% CIs 1.27 to 15.74, p = 0.02). The presence of LGE in patients with NICMP strongly predicts the occurrence of adverse events. In conclusion, this may be important in risk stratification and management.

Original languageEnglish (US)
Pages (from-to)1063-1068
Number of pages6
JournalAmerican Journal of Cardiology
Volume118
Issue number7
DOIs
StatePublished - Oct 1 2016

Fingerprint

Gadolinium
Cardiomyopathies
Stroke Volume
Magnetic Resonance Spectroscopy
Implantable Defibrillators
Risk Management
Disease-Free Survival
Hospitalization
Heart Failure
Magnetic Resonance Imaging
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Prognostic Value of Late Gadolinium Enhancement in Nonischemic Cardiomyopathy. / Gaztanaga, Juan; Paruchuri, Vijayapraveena; Elias, Elliott; Wilner, Jonathan; Islam, Shahidul; Sawit, Simonette; Viles-Gonzalez, Juan; Sanz, Javier; Garcia, Mario J.

In: American Journal of Cardiology, Vol. 118, No. 7, 01.10.2016, p. 1063-1068.

Research output: Contribution to journalArticle

Gaztanaga, J, Paruchuri, V, Elias, E, Wilner, J, Islam, S, Sawit, S, Viles-Gonzalez, J, Sanz, J & Garcia, MJ 2016, 'Prognostic Value of Late Gadolinium Enhancement in Nonischemic Cardiomyopathy', American Journal of Cardiology, vol. 118, no. 7, pp. 1063-1068. https://doi.org/10.1016/j.amjcard.2016.06.059
Gaztanaga J, Paruchuri V, Elias E, Wilner J, Islam S, Sawit S et al. Prognostic Value of Late Gadolinium Enhancement in Nonischemic Cardiomyopathy. American Journal of Cardiology. 2016 Oct 1;118(7):1063-1068. https://doi.org/10.1016/j.amjcard.2016.06.059
Gaztanaga, Juan ; Paruchuri, Vijayapraveena ; Elias, Elliott ; Wilner, Jonathan ; Islam, Shahidul ; Sawit, Simonette ; Viles-Gonzalez, Juan ; Sanz, Javier ; Garcia, Mario J. / Prognostic Value of Late Gadolinium Enhancement in Nonischemic Cardiomyopathy. In: American Journal of Cardiology. 2016 ; Vol. 118, No. 7. pp. 1063-1068.
@article{4c5469f9e5d84e4aa5d1554c809fa90e,
title = "Prognostic Value of Late Gadolinium Enhancement in Nonischemic Cardiomyopathy",
abstract = "The purpose of this study was to determine the prognostic value of late gadolinium enhancement seen on cardiac magnetic resonance (CMR) imaging in patients with nonischemic cardiomyopathy (NICMP). Patients with NICMP are at increased risk for cardiovascular events and death. The presence of late gadolinium enhancement (LGE) in CMR may be associated with a poor prognosis, but its significance is still under investigation. We retrospectively studied 105 consecutive patients with NICMP and left ventricular ejection fraction (LVEF) ≤40{\%} referred for CMR. The cohort was analyzed for the presence of LGE and left and right ventricular functional parameters. Patients were followed for the composite end point of hospitalization for congestive heart failure, appropriate implantable cardioverter-defibrillator therapy, or all-cause mortality. LGE was observed in 68{\%} (n = 71) of the cohort. Both groups were similar in age, LVEF and LV end-diastolic volume. The LGE+ patients were more often men and had larger right ventricular volumes. At a mean follow-up of 806 ± 582 days, there were 26 patients (23 in the LGE+ group) who reached the primary end point. Event-free survival was significantly worse for the LGE+ patients. After adjusting for traditional risk factors (age, gender, and LVEF), patients with LGE had an increased risk of experiencing the primary end point (hazard ratio 4.47, 95{\%} CIs 1.27 to 15.74, p = 0.02). The presence of LGE in patients with NICMP strongly predicts the occurrence of adverse events. In conclusion, this may be important in risk stratification and management.",
author = "Juan Gaztanaga and Vijayapraveena Paruchuri and Elliott Elias and Jonathan Wilner and Shahidul Islam and Simonette Sawit and Juan Viles-Gonzalez and Javier Sanz and Garcia, {Mario J.}",
year = "2016",
month = "10",
day = "1",
doi = "10.1016/j.amjcard.2016.06.059",
language = "English (US)",
volume = "118",
pages = "1063--1068",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Prognostic Value of Late Gadolinium Enhancement in Nonischemic Cardiomyopathy

AU - Gaztanaga, Juan

AU - Paruchuri, Vijayapraveena

AU - Elias, Elliott

AU - Wilner, Jonathan

AU - Islam, Shahidul

AU - Sawit, Simonette

AU - Viles-Gonzalez, Juan

AU - Sanz, Javier

AU - Garcia, Mario J.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - The purpose of this study was to determine the prognostic value of late gadolinium enhancement seen on cardiac magnetic resonance (CMR) imaging in patients with nonischemic cardiomyopathy (NICMP). Patients with NICMP are at increased risk for cardiovascular events and death. The presence of late gadolinium enhancement (LGE) in CMR may be associated with a poor prognosis, but its significance is still under investigation. We retrospectively studied 105 consecutive patients with NICMP and left ventricular ejection fraction (LVEF) ≤40% referred for CMR. The cohort was analyzed for the presence of LGE and left and right ventricular functional parameters. Patients were followed for the composite end point of hospitalization for congestive heart failure, appropriate implantable cardioverter-defibrillator therapy, or all-cause mortality. LGE was observed in 68% (n = 71) of the cohort. Both groups were similar in age, LVEF and LV end-diastolic volume. The LGE+ patients were more often men and had larger right ventricular volumes. At a mean follow-up of 806 ± 582 days, there were 26 patients (23 in the LGE+ group) who reached the primary end point. Event-free survival was significantly worse for the LGE+ patients. After adjusting for traditional risk factors (age, gender, and LVEF), patients with LGE had an increased risk of experiencing the primary end point (hazard ratio 4.47, 95% CIs 1.27 to 15.74, p = 0.02). The presence of LGE in patients with NICMP strongly predicts the occurrence of adverse events. In conclusion, this may be important in risk stratification and management.

AB - The purpose of this study was to determine the prognostic value of late gadolinium enhancement seen on cardiac magnetic resonance (CMR) imaging in patients with nonischemic cardiomyopathy (NICMP). Patients with NICMP are at increased risk for cardiovascular events and death. The presence of late gadolinium enhancement (LGE) in CMR may be associated with a poor prognosis, but its significance is still under investigation. We retrospectively studied 105 consecutive patients with NICMP and left ventricular ejection fraction (LVEF) ≤40% referred for CMR. The cohort was analyzed for the presence of LGE and left and right ventricular functional parameters. Patients were followed for the composite end point of hospitalization for congestive heart failure, appropriate implantable cardioverter-defibrillator therapy, or all-cause mortality. LGE was observed in 68% (n = 71) of the cohort. Both groups were similar in age, LVEF and LV end-diastolic volume. The LGE+ patients were more often men and had larger right ventricular volumes. At a mean follow-up of 806 ± 582 days, there were 26 patients (23 in the LGE+ group) who reached the primary end point. Event-free survival was significantly worse for the LGE+ patients. After adjusting for traditional risk factors (age, gender, and LVEF), patients with LGE had an increased risk of experiencing the primary end point (hazard ratio 4.47, 95% CIs 1.27 to 15.74, p = 0.02). The presence of LGE in patients with NICMP strongly predicts the occurrence of adverse events. In conclusion, this may be important in risk stratification and management.

UR - http://www.scopus.com/inward/record.url?scp=84991574366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84991574366&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2016.06.059

DO - 10.1016/j.amjcard.2016.06.059

M3 - Article

VL - 118

SP - 1063

EP - 1068

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 7

ER -