Prognostic implications of lymph node involvement in bladder cancer: Are we understaging using current methods?

Kara L. Watts, Benjamin T. Ristau, Harold T. Yamase, John A. Taylor

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

To review the current and newer, alternative methods for evaluating lymph nodes for tumor involvement in bladder cancer as relapse rates for organ-confined disease remain high despite improvements in surgical technique, suggesting the possibility of understaging. To propose a research agenda based on these findings. A PubMed literature search was performed to identify studies examining the prognostic implications of and outcomes associated with lymph node involvement in bladder cancer as well as those that utilized newer methodologies to identify the possibility for metastatic disease. Lymph node involvement remains one of the strongest predictors of clinical outcome in bladder cancer. Histologic and molecular techniques for identification of lymph node metastasis provide a sensitivity and specificity equal to if not higher than standard pathologic evaluation. Further research into this field would help to elucidate the potential utility of these techniques with regard to proper staging and potential relevance to clinical outcomes.

Original languageEnglish (US)
Pages (from-to)484-492
Number of pages9
JournalBJU International
Volume108
Issue number4
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

Fingerprint

Urinary Bladder Neoplasms
Lymph Nodes
Histological Techniques
Research
PubMed
Neoplasm Metastasis
Recurrence
Sensitivity and Specificity
Neoplasms

Keywords

  • Bladder
  • Cancer
  • Lymph node
  • Metastasis
  • Staging

ASJC Scopus subject areas

  • Urology

Cite this

Prognostic implications of lymph node involvement in bladder cancer : Are we understaging using current methods? / Watts, Kara L.; Ristau, Benjamin T.; Yamase, Harold T.; Taylor, John A.

In: BJU International, Vol. 108, No. 4, 01.08.2011, p. 484-492.

Research output: Contribution to journalReview article

Watts, Kara L. ; Ristau, Benjamin T. ; Yamase, Harold T. ; Taylor, John A. / Prognostic implications of lymph node involvement in bladder cancer : Are we understaging using current methods?. In: BJU International. 2011 ; Vol. 108, No. 4. pp. 484-492.
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