Progesterone withdrawal increases the anxiolytic actions of gaboxadol: Role of α4βδ GABAA receptors

M. Gulinello, Q. H. Gong, S. S. Smith

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Hippocampal α4βδ GABAA receptors (GABAA-R) are increased following progesterone withdrawal (PWD) in a rodent model of premenstrual anxiety. This α4βδ receptor isoform uniquely responds to the GABA agonist gaboxadol (THIP) with a maximum current greater than that gated by GABA, and is potentiated more by pentobarbital than are other GABAA-R. We therefore investigated the anxiolytic effects of these drugs using the elevated plus maze. Gaboxadol (1.25 mg/kg) was markedly more anxiolytic in animals undergoing PWD than in controls. Pentobarbital (10 mg/kg) also produced a greater anxiolytic effect during PWD. These results suggest that the pharmacological properties of α4βδ GABAA-R following PWD are evident behaviorally. Alterations in the α4βδ GABAA-R population may have implications for the etiology and treatment of premenstrual syndrome.

Original languageEnglish (US)
Pages (from-to)43-46
Number of pages4
JournalNeuroReport
Volume14
Issue number1
DOIs
StatePublished - Jan 20 2003

Keywords

  • Allopregnanolone
  • Anxiety
  • Extra-synaptic
  • GABA receptor
  • Neurosteroid
  • Premenstrual syndrome
  • Progesterone
  • Tonic current
  • α4 subunit
  • δ subunit

ASJC Scopus subject areas

  • Neuroscience(all)

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