Profound "pacemaker syndrome" in hypertrophic cardiomyopathy

Jay N. Gross, Theodore N. Keltz, Jerome A. Cooper, Sheldon Breitbart, Seymour Furman

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Hypertrophic cardiomyopathy (HC) results in depressed cardiac output and pulmonary congestion from decreased left ventricular diastolic compliance, and in a large subset of patients is further complicated by dynamic left ventricular outflow tract obstruction. Complete atrioventricular (AV) block can induce severe hemodynamic compromise and is particularly dangerous in patients with structural heart disease. The incidence of spontaneous AV block in patients with HC is unknown but is the subject of numerous clinical and electrophysiologic reports.1-11 The use of β blockers and calcium channel antagonists in patients with HC may independently induce rhythms that compromise normal AV synchrony. "Pacemaker syndrome" refers to the occurrence of symptoms in patients managed with single-rate ventricular pacing who develop the adverse electrophysiologic and hemodynamic consequences of the loss of AV synchrony.12 Rarely has serious hemodynamic compromise been noted. This syndrome is similar to the hemodynamic events described in 3 patients with HC and profound hemodynamic impairment due to the loss of AV synchrony.

Original languageEnglish (US)
Pages (from-to)1507-1511
Number of pages5
JournalThe American Journal of Cardiology
Volume70
Issue number18
DOIs
StatePublished - Dec 1 1992

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Hypertrophic Cardiomyopathy
Hemodynamics
Atrioventricular Block
Ventricular Outflow Obstruction
Calcium Channel Blockers
Cardiac Output
Compliance
Heart Diseases
Lung
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Profound "pacemaker syndrome" in hypertrophic cardiomyopathy. / Gross, Jay N.; Keltz, Theodore N.; Cooper, Jerome A.; Breitbart, Sheldon; Furman, Seymour.

In: The American Journal of Cardiology, Vol. 70, No. 18, 01.12.1992, p. 1507-1511.

Research output: Contribution to journalArticle

Gross, Jay N. ; Keltz, Theodore N. ; Cooper, Jerome A. ; Breitbart, Sheldon ; Furman, Seymour. / Profound "pacemaker syndrome" in hypertrophic cardiomyopathy. In: The American Journal of Cardiology. 1992 ; Vol. 70, No. 18. pp. 1507-1511.
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