Production of Melanins by Ceruloplasmin

Maria Anna Rosei, Cesira Foppoli, Xintao Wang, Raffaella Coccia, Mircea Alexandru Mateescu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

It was shown that ceruloplasmin, apart from the known oxidative conversion of dopamine into melanin, can also produce (DHI)-melanin from 5,6-dihydroxyindole and THP-melanin from tetrahydropapaveroline. Ceruloplasmin acts as an oxidase and the kinetic parameters for these oxidative reactions are reported. Since these ceruloplasmin-catalyzed reactions occur also at pH 7.4, they could have a significant physiological impact. This ceruloplasmin-oxidasic activity is enhanced by copper ions and inhibited by chelators, such as ethylenediaminetetraacetic acid (EDTA) and desferoxamine (DEF). Some possible implication of melanin production in blood are discussed.

Original languageEnglish (US)
Pages (from-to)98-102
Number of pages5
JournalPigment Cell Research
Volume11
Issue number2
StatePublished - Apr 1998
Externally publishedYes

Fingerprint

ferroxidase
Ceruloplasmin
Melanins
melanin
Tetrahydropapaveroline
EDTA (chelating agent)
Chelating Agents
chelating agents
dopamine
Kinetic parameters
Edetic Acid
Copper
Dopamine
Oxidoreductases
Blood
copper
Ions
ions
kinetics
blood

Keywords

  • 5,6-dihydroxyindoles
  • Ceruloplasmin
  • Melanin
  • Tetrahydropapaveroline

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Plant Science
  • Cell Biology
  • Clinical Biochemistry
  • Developmental Biology

Cite this

Rosei, M. A., Foppoli, C., Wang, X., Coccia, R., & Mateescu, M. A. (1998). Production of Melanins by Ceruloplasmin. Pigment Cell Research, 11(2), 98-102.

Production of Melanins by Ceruloplasmin. / Rosei, Maria Anna; Foppoli, Cesira; Wang, Xintao; Coccia, Raffaella; Mateescu, Mircea Alexandru.

In: Pigment Cell Research, Vol. 11, No. 2, 04.1998, p. 98-102.

Research output: Contribution to journalArticle

Rosei, MA, Foppoli, C, Wang, X, Coccia, R & Mateescu, MA 1998, 'Production of Melanins by Ceruloplasmin', Pigment Cell Research, vol. 11, no. 2, pp. 98-102.
Rosei MA, Foppoli C, Wang X, Coccia R, Mateescu MA. Production of Melanins by Ceruloplasmin. Pigment Cell Research. 1998 Apr;11(2):98-102.
Rosei, Maria Anna ; Foppoli, Cesira ; Wang, Xintao ; Coccia, Raffaella ; Mateescu, Mircea Alexandru. / Production of Melanins by Ceruloplasmin. In: Pigment Cell Research. 1998 ; Vol. 11, No. 2. pp. 98-102.
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