Production of Melanins by Ceruloplasmin

Maria Anna Rosei, Cesira Foppoli, Xin Tao Wang, Raffaella Coccia, Mircea Alexandru Mateescu

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


It was shown that ceruloplasmin, apart from the known oxidative conversion of dopamine into melanin, can also produce (DHI)-melanin from 5,6-dihydroxyindole and THP-melanin from tetrahydropapaveroline. Ceruloplasmin acts as an oxidase and the kinetic parameters for these oxidative reactions are reported. Since these ceruloplasmin-catalyzed reactions occur also at pH 7.4, they could have a significant physiological impact. This ceruloplasmin-oxidasic activity is enhanced by copper ions and inhibited by chelators, such as ethylenediaminetetraacetic acid (EDTA) and desferoxamine (DEF). Some possible implication of melanin production in blood are discussed.

Original languageEnglish (US)
Pages (from-to)98-102
Number of pages5
JournalPigment Cell Research
Issue number2
StatePublished - Apr 1998


  • 5,6-dihydroxyindoles
  • Ceruloplasmin
  • Melanin
  • Tetrahydropapaveroline

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Plant Science
  • Developmental Biology
  • Clinical Biochemistry
  • Cell Biology

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