Production of Melanins by Ceruloplasmin

Maria Anna Rosei; Cesira Foppoli; Xin Tao Wang; Raffaella Coccia; Mircea Alexandru Mateescu

doi:10.1111/j.1600-0749.1998.tb00717.x

Production of Melanins by Ceruloplasmin

Maria Anna Rosei, Cesira Foppoli, Xin Tao Wang, Raffaella Coccia, Mircea Alexandru Mateescu

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

It was shown that ceruloplasmin, apart from the known oxidative conversion of dopamine into melanin, can also produce (DHI)-melanin from 5,6-dihydroxyindole and THP-melanin from tetrahydropapaveroline. Ceruloplasmin acts as an oxidase and the kinetic parameters for these oxidative reactions are reported. Since these ceruloplasmin-catalyzed reactions occur also at pH 7.4, they could have a significant physiological impact. This ceruloplasmin-oxidasic activity is enhanced by copper ions and inhibited by chelators, such as ethylenediaminetetraacetic acid (EDTA) and desferoxamine (DEF). Some possible implication of melanin production in blood are discussed.

Original language	English (US)
Pages (from-to)	98-102
Number of pages	5
Journal	Pigment Cell Research
Volume	11
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0749.1998.tb00717.x
State	Published - Apr 1998
Externally published	Yes

Keywords

5,6-dihydroxyindoles
Ceruloplasmin
Melanin
Tetrahydropapaveroline

ASJC Scopus subject areas

Agronomy and Crop Science
Plant Science
Developmental Biology
Clinical Biochemistry
Cell Biology

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10.1111/j.1600-0749.1998.tb00717.x

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title = "Production of Melanins by Ceruloplasmin",

abstract = "It was shown that ceruloplasmin, apart from the known oxidative conversion of dopamine into melanin, can also produce (DHI)-melanin from 5,6-dihydroxyindole and THP-melanin from tetrahydropapaveroline. Ceruloplasmin acts as an oxidase and the kinetic parameters for these oxidative reactions are reported. Since these ceruloplasmin-catalyzed reactions occur also at pH 7.4, they could have a significant physiological impact. This ceruloplasmin-oxidasic activity is enhanced by copper ions and inhibited by chelators, such as ethylenediaminetetraacetic acid (EDTA) and desferoxamine (DEF). Some possible implication of melanin production in blood are discussed.",

keywords = "5,6-dihydroxyindoles, Ceruloplasmin, Melanin, Tetrahydropapaveroline",

author = "Rosei, {Maria Anna} and Cesira Foppoli and Wang, {Xin Tao} and Raffaella Coccia and Mateescu, {Mircea Alexandru}",

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}

TY - JOUR

T1 - Production of Melanins by Ceruloplasmin

AU - Rosei, Maria Anna

AU - Foppoli, Cesira

AU - Wang, Xin Tao

AU - Coccia, Raffaella

AU - Mateescu, Mircea Alexandru

PY - 1998/4

Y1 - 1998/4

N2 - It was shown that ceruloplasmin, apart from the known oxidative conversion of dopamine into melanin, can also produce (DHI)-melanin from 5,6-dihydroxyindole and THP-melanin from tetrahydropapaveroline. Ceruloplasmin acts as an oxidase and the kinetic parameters for these oxidative reactions are reported. Since these ceruloplasmin-catalyzed reactions occur also at pH 7.4, they could have a significant physiological impact. This ceruloplasmin-oxidasic activity is enhanced by copper ions and inhibited by chelators, such as ethylenediaminetetraacetic acid (EDTA) and desferoxamine (DEF). Some possible implication of melanin production in blood are discussed.

AB - It was shown that ceruloplasmin, apart from the known oxidative conversion of dopamine into melanin, can also produce (DHI)-melanin from 5,6-dihydroxyindole and THP-melanin from tetrahydropapaveroline. Ceruloplasmin acts as an oxidase and the kinetic parameters for these oxidative reactions are reported. Since these ceruloplasmin-catalyzed reactions occur also at pH 7.4, they could have a significant physiological impact. This ceruloplasmin-oxidasic activity is enhanced by copper ions and inhibited by chelators, such as ethylenediaminetetraacetic acid (EDTA) and desferoxamine (DEF). Some possible implication of melanin production in blood are discussed.

KW - 5,6-dihydroxyindoles

KW - Ceruloplasmin

KW - Melanin

KW - Tetrahydropapaveroline

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Production of Melanins by Ceruloplasmin

Abstract

Keywords

ASJC Scopus subject areas

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