Probing the microenvironment of mammary tumors using multiphoton microscopy

Mazen Sidani, Jeffrey Wyckoff, Chengsen Xue, Jeffrey E. Segall, John S. Condeelis

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Advances in optical imaging technologies that allow the subcellular resolution of undissected tissue have begun to offer new clues into the biology of development and disease. For cancer, such advances mean that the primary tumor is no longer a black box and that the disease can be studied throughout the metastatic cascade and not just as an endpoint. In this review we examine the advances in multiphoton imaging technology that have been used to define the microenvironment and its role in delineating the invasion and intravasation steps of metastasis inside living mammary tumors. Results show that the tumor microenvironment is a dynamic place where interactions between tumor cells, macrophages, blood vessels, and extracellular matrix fibers define the metastatic phenotype.

Original languageEnglish (US)
Pages (from-to)151-163
Number of pages13
JournalJournal of Mammary Gland Biology and Neoplasia
Volume11
Issue number2
DOIs
StatePublished - Apr 2006

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Microscopy
Breast Neoplasms
Technology
Neoplasms
Tumor Microenvironment
Optical Imaging
Extracellular Matrix
Blood Vessels
Macrophages
Neoplasm Metastasis
Phenotype

Keywords

  • Breast cancer
  • GFP
  • Intravital imaging
  • Real-time imaging
  • Second harmonic generation

ASJC Scopus subject areas

  • Cancer Research

Cite this

Probing the microenvironment of mammary tumors using multiphoton microscopy. / Sidani, Mazen; Wyckoff, Jeffrey; Xue, Chengsen; Segall, Jeffrey E.; Condeelis, John S.

In: Journal of Mammary Gland Biology and Neoplasia, Vol. 11, No. 2, 04.2006, p. 151-163.

Research output: Contribution to journalArticle

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