Prevalence of migraine headaches in patients with allergic rhinitis

Min Ku, Bernard A. Silverman, Nausika Prifti, Wei Ying, Yudy Persaud, Arlene Schneider

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background: Histamine has been implicated in the pathogenesis of migraine headaches. Because allergic rhinitis (AR) is a histamine-driven syndrome and the nasal passage is in close proximity to the central nervous system, we hypothesize that AR may trigger migraine headaches. Objective: To determine the prevalence of migraine headaches in patients with and without AR. Methods: Allergic rhinitis was diagnosed based on skin or radioallergosorbent test results, clinical history, and physical examination findings. The diagnosis of migraine headache was made if patients fulfilled the International Headache Society criteria. Surveys were obtained from hospital-based allergy, pediatric, and internal medicine clinics, all serving the same inner-city population. Results: A total of 294 surveys were completed. Of 76 patients in the AR group, 26 (34%) had headaches meeting the International Headache Society criteria for migraines, and of the 57 patients in the non-AR group, only 2 (4%) had headaches that met the criteria. A Fisher exact test showed P = 8.2 × 10 -6. The odds ratio was 14.3, which signifies that the odds of having migraine headaches is 14.3 times higher in the AR group than in the non-AR group. Conclusions: There is a high prevalence of migraine headaches in patients with AR compared with those without AR. We propose that histamine plays a key role in triggering migraines by means of vasodilation and inflammation in the pathogenesis of migraine headaches.

Original languageEnglish (US)
Pages (from-to)226-230
Number of pages5
JournalAnnals of Allergy, Asthma and Immunology
Volume97
Issue number2
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

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Migraine Disorders
Headache
Histamine
Rhinitis
Radioallergosorbent Test
Allergic Rhinitis
Internal Medicine
Skin Tests
Nose
Vasodilation
Physical Examination
Hypersensitivity
Central Nervous System
Odds Ratio
Pediatrics
Inflammation
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Prevalence of migraine headaches in patients with allergic rhinitis. / Ku, Min; Silverman, Bernard A.; Prifti, Nausika; Ying, Wei; Persaud, Yudy; Schneider, Arlene.

In: Annals of Allergy, Asthma and Immunology, Vol. 97, No. 2, 01.01.2006, p. 226-230.

Research output: Contribution to journalArticle

Ku, Min ; Silverman, Bernard A. ; Prifti, Nausika ; Ying, Wei ; Persaud, Yudy ; Schneider, Arlene. / Prevalence of migraine headaches in patients with allergic rhinitis. In: Annals of Allergy, Asthma and Immunology. 2006 ; Vol. 97, No. 2. pp. 226-230.
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