Prevalence of lower genital tract infections among human immunodeficiency virus (HIV)-seropositive and high-risk HIV-seronegative women

Susan Cu-Uvin, Joseph W. Hogan, Dora Warren, Robert S. Klein, Jeffrey Peipert, Paula Schuman, Scott Holmberg, Jean Anderson, Ellie Schoenbaum, David Vlahov, Kenneth H. Mayer

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

This study was undertaken to assess whether the prevalence of lower genital tract infections among human immunodeficiency virus (HIV)- seropositive women was higher than among high-risk HIV-seronegative women at their baseline visit for the HIV Epidemiology Research Study. Results were available for 851 HIV-seropositive and 434 HIV-seronegative women. Human papilloma virus (HPV) infection was more prevalent among HIV-seropositive women (64% vs. 28%). Bacterial vaginosis was common (35% vs. 33%), followed by trichomoniasis (12% vs. 10%), syphilis (8% vs. 6%), Chlamydia trachomatis infection (4% vs. 5%), candidal vaginitis (3% vs. 2%), and Neisseria gonorrhoeae infection (0.8% vs. 0.3%). Alcohol use (odds ratio [OR], 1.8; 95% confidence interval [CI], 1.3-2.4) and smoking (OR, 1.8; 95% CI, 1.3-2.5) were associated with bacterial vaginosis. Bacterial vaginosis (OR, 2.3; 95% CI, 1.5-3.4), trichomoniasis (OR, 2.3; 95% CI, 1.1-4.7), and syphilis (OR, 3.1; 95% CI, 1.3-7.4) were found to be more prevalent among black women. Our study showed no statistically significant difference in the prevalence of lower genital tract infections except for HPV between HIV-infected and demographically and behaviorally similar HIV-uninfected high-risk women.

Original languageEnglish (US)
Pages (from-to)1145-1150
Number of pages6
JournalClinical Infectious Diseases
Volume29
Issue number5
DOIs
StatePublished - Dec 1 1999

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Cu-Uvin, S., Hogan, J. W., Warren, D., Klein, R. S., Peipert, J., Schuman, P., Holmberg, S., Anderson, J., Schoenbaum, E., Vlahov, D., & Mayer, K. H. (1999). Prevalence of lower genital tract infections among human immunodeficiency virus (HIV)-seropositive and high-risk HIV-seronegative women. Clinical Infectious Diseases, 29(5), 1145-1150. https://doi.org/10.1086/313434