Prevalence and predictors of hospitalizations among HIV-Infected and at-risk HIV-Uninfected Women

Anna L. Hotton, Kathleen M. Weber, Ronald C. Hershow, Kathryn Anastos, Peter Bacchetti, Elizabeth T. Golub, Deborah Gustafson, Alexandra M. Levine, Mary Young, Mardge H. Cohen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVES:: We evaluated the Veterans Aging Cohort Study (VACS) Index score, an index composed of age, CD4 count, viral load, hemoglobin, Hepatitis C (HCV) co-infection, Fibrosis Index-4 (FIB-4), and estimated glomerular filtration rate (EGFR), and psychosocial and clinical risk factors for all-cause hospitalization among HIV-infected women on HAART and HIV-uninfected women. METHODS:: Data were collected from 2008 - 2014 from 1585 HAART-experienced HIV-infected and 692 uninfected women. Cox proportional hazards regression evaluated predictors of first hospitalization over 2 years. RESULTS:: Among HIV-infected women, VACS Index score (per 5 points) (adjusted hazard ratio [aHR]1.08; 95% CI 1.06-1.11), Centers for Epidemiologic Studies-Depression (CES-D) scores ≥16 (aHR 1.61; 95% CI 1.30-1.99), smoking (aHR 1.26; 95% CI 1.02-1.55), abuse history (aHR 1.52; 95% CI 1.20-1.93), diabetes (aHR 1.63; 95% CI 1.31-2.04), and black race (aHR 1.28; 95% CI 1.03-1.59) increased risk of hospitalization. Among HIV-uninfected women, VACS Index score (aHR 1.08; 95% CI 1.03-1.13), CES-D ≥16 (aHR 1.38; 95% CI 1.02-1.86), diabetes (aHR 2.15; 95% CI 1.57-2.95), and black race (aHR 1.61; 95% CI 1.15-2.24) predicted subsequent hospitalization. CONCLUSIONS:: Psychosocial and clinical factors were associated with risk of hospitalization independently of the VACS Index score. Additional research on contextual and psychosocial influences on health outcomes among women is needed.

Original languageEnglish (US)
JournalJournal of Acquired Immune Deficiency Syndromes
DOIs
StateAccepted/In press - Dec 17 2016

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Hospitalization
HIV
Veterans
Cohort Studies
Highly Active Antiretroviral Therapy
Epidemiologic Studies
Hemoglobin C
Depression
CD4 Lymphocyte Count
Hepatitis C
Viral Load
Coinfection
Glomerular Filtration Rate
Fibrosis
Smoking
Psychology
Health
Research

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Prevalence and predictors of hospitalizations among HIV-Infected and at-risk HIV-Uninfected Women. / Hotton, Anna L.; Weber, Kathleen M.; Hershow, Ronald C.; Anastos, Kathryn; Bacchetti, Peter; Golub, Elizabeth T.; Gustafson, Deborah; Levine, Alexandra M.; Young, Mary; Cohen, Mardge H.

In: Journal of Acquired Immune Deficiency Syndromes, 17.12.2016.

Research output: Contribution to journalArticle

Hotton, Anna L. ; Weber, Kathleen M. ; Hershow, Ronald C. ; Anastos, Kathryn ; Bacchetti, Peter ; Golub, Elizabeth T. ; Gustafson, Deborah ; Levine, Alexandra M. ; Young, Mary ; Cohen, Mardge H. / Prevalence and predictors of hospitalizations among HIV-Infected and at-risk HIV-Uninfected Women. In: Journal of Acquired Immune Deficiency Syndromes. 2016.
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abstract = "OBJECTIVES:: We evaluated the Veterans Aging Cohort Study (VACS) Index score, an index composed of age, CD4 count, viral load, hemoglobin, Hepatitis C (HCV) co-infection, Fibrosis Index-4 (FIB-4), and estimated glomerular filtration rate (EGFR), and psychosocial and clinical risk factors for all-cause hospitalization among HIV-infected women on HAART and HIV-uninfected women. METHODS:: Data were collected from 2008 - 2014 from 1585 HAART-experienced HIV-infected and 692 uninfected women. Cox proportional hazards regression evaluated predictors of first hospitalization over 2 years. RESULTS:: Among HIV-infected women, VACS Index score (per 5 points) (adjusted hazard ratio [aHR]1.08; 95{\%} CI 1.06-1.11), Centers for Epidemiologic Studies-Depression (CES-D) scores ≥16 (aHR 1.61; 95{\%} CI 1.30-1.99), smoking (aHR 1.26; 95{\%} CI 1.02-1.55), abuse history (aHR 1.52; 95{\%} CI 1.20-1.93), diabetes (aHR 1.63; 95{\%} CI 1.31-2.04), and black race (aHR 1.28; 95{\%} CI 1.03-1.59) increased risk of hospitalization. Among HIV-uninfected women, VACS Index score (aHR 1.08; 95{\%} CI 1.03-1.13), CES-D ≥16 (aHR 1.38; 95{\%} CI 1.02-1.86), diabetes (aHR 2.15; 95{\%} CI 1.57-2.95), and black race (aHR 1.61; 95{\%} CI 1.15-2.24) predicted subsequent hospitalization. CONCLUSIONS:: Psychosocial and clinical factors were associated with risk of hospitalization independently of the VACS Index score. Additional research on contextual and psychosocial influences on health outcomes among women is needed.",
author = "Hotton, {Anna L.} and Weber, {Kathleen M.} and Hershow, {Ronald C.} and Kathryn Anastos and Peter Bacchetti and Golub, {Elizabeth T.} and Deborah Gustafson and Levine, {Alexandra M.} and Mary Young and Cohen, {Mardge H.}",
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T1 - Prevalence and predictors of hospitalizations among HIV-Infected and at-risk HIV-Uninfected Women

AU - Hotton, Anna L.

AU - Weber, Kathleen M.

AU - Hershow, Ronald C.

AU - Anastos, Kathryn

AU - Bacchetti, Peter

AU - Golub, Elizabeth T.

AU - Gustafson, Deborah

AU - Levine, Alexandra M.

AU - Young, Mary

AU - Cohen, Mardge H.

PY - 2016/12/17

Y1 - 2016/12/17

N2 - OBJECTIVES:: We evaluated the Veterans Aging Cohort Study (VACS) Index score, an index composed of age, CD4 count, viral load, hemoglobin, Hepatitis C (HCV) co-infection, Fibrosis Index-4 (FIB-4), and estimated glomerular filtration rate (EGFR), and psychosocial and clinical risk factors for all-cause hospitalization among HIV-infected women on HAART and HIV-uninfected women. METHODS:: Data were collected from 2008 - 2014 from 1585 HAART-experienced HIV-infected and 692 uninfected women. Cox proportional hazards regression evaluated predictors of first hospitalization over 2 years. RESULTS:: Among HIV-infected women, VACS Index score (per 5 points) (adjusted hazard ratio [aHR]1.08; 95% CI 1.06-1.11), Centers for Epidemiologic Studies-Depression (CES-D) scores ≥16 (aHR 1.61; 95% CI 1.30-1.99), smoking (aHR 1.26; 95% CI 1.02-1.55), abuse history (aHR 1.52; 95% CI 1.20-1.93), diabetes (aHR 1.63; 95% CI 1.31-2.04), and black race (aHR 1.28; 95% CI 1.03-1.59) increased risk of hospitalization. Among HIV-uninfected women, VACS Index score (aHR 1.08; 95% CI 1.03-1.13), CES-D ≥16 (aHR 1.38; 95% CI 1.02-1.86), diabetes (aHR 2.15; 95% CI 1.57-2.95), and black race (aHR 1.61; 95% CI 1.15-2.24) predicted subsequent hospitalization. CONCLUSIONS:: Psychosocial and clinical factors were associated with risk of hospitalization independently of the VACS Index score. Additional research on contextual and psychosocial influences on health outcomes among women is needed.

AB - OBJECTIVES:: We evaluated the Veterans Aging Cohort Study (VACS) Index score, an index composed of age, CD4 count, viral load, hemoglobin, Hepatitis C (HCV) co-infection, Fibrosis Index-4 (FIB-4), and estimated glomerular filtration rate (EGFR), and psychosocial and clinical risk factors for all-cause hospitalization among HIV-infected women on HAART and HIV-uninfected women. METHODS:: Data were collected from 2008 - 2014 from 1585 HAART-experienced HIV-infected and 692 uninfected women. Cox proportional hazards regression evaluated predictors of first hospitalization over 2 years. RESULTS:: Among HIV-infected women, VACS Index score (per 5 points) (adjusted hazard ratio [aHR]1.08; 95% CI 1.06-1.11), Centers for Epidemiologic Studies-Depression (CES-D) scores ≥16 (aHR 1.61; 95% CI 1.30-1.99), smoking (aHR 1.26; 95% CI 1.02-1.55), abuse history (aHR 1.52; 95% CI 1.20-1.93), diabetes (aHR 1.63; 95% CI 1.31-2.04), and black race (aHR 1.28; 95% CI 1.03-1.59) increased risk of hospitalization. Among HIV-uninfected women, VACS Index score (aHR 1.08; 95% CI 1.03-1.13), CES-D ≥16 (aHR 1.38; 95% CI 1.02-1.86), diabetes (aHR 2.15; 95% CI 1.57-2.95), and black race (aHR 1.61; 95% CI 1.15-2.24) predicted subsequent hospitalization. CONCLUSIONS:: Psychosocial and clinical factors were associated with risk of hospitalization independently of the VACS Index score. Additional research on contextual and psychosocial influences on health outcomes among women is needed.

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