Prevalence and cumulative incidence of and risk factors for anemia in a multicenter cohort study of human immunodeficiency virus-infected and -uninfected women

Richard D. Semba, Robert S. Klein, Kenneth H. Mayer, Paula Schuman, David Vlahov, Robert S. Klein, Ellie Schoenbaum, Julia H. Arnsten, Robert D. Burk, Chee Jen Chang, Penelope Demas, Andrea Howard, Paula Schuman, Jack Sobel, Anne Rompalo, David Vlahov, David Celentano, Nina Shah, Charles Carpenter, Kenneth MayerSusan Cu-Uvin, Timothy Flanigan, Joseph Hogan, Valerie Stone, Karen Tashima, Josiah Rich, Ann Duerr, Lytt I. Gardner, Chad Heilig, Scott D. Holmberg, Denise J. Jamieson, Janet S. Moore, Ruby M. Phelps, Dawn K. Smith, Dora Warren, Katherine Davenny

Research output: Contribution to journalArticle

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Abstract

We conducted a longitudinal study of 797 human immunodeficiency virus (HIV)-positive women (7732 visits) and 389 HIV-negative women (3651 visits) to characterize anemia. At enrollment, the prevalence of anemia was 28.1% among HIV-positive women and 15.1% among HIV-negative women (P<.0001), and during follow-up the cumulative incidence of anemia was 74% and 48%, respectively (P<.0001). Risk factors for anemia were African American race (odds ratio [OR], 2.15; 95% confidence interval [CI], 1.73-2.69), age (per 5-year increase; OR, 1.12; 95% CI, 1.03-1.21), body mass index (OR, 0.96; 95% CI, 0.94-0.97), history of pneumonia (OR, 1.41; 95% CI, 1.20-1.65), oral candidiasis (OR, 1.42; 95% CI, 1.22-1.66), CD4+ lymphocyte count <200 cells/μL (OR, 1.68; 95% CI, 1.46-1.94), history of fever (OR, 1.42; 95% CI, 1.13-1.80), and zidovudine use (OR, 1.14; 95% CI, 1.01-1.30). Anemia was common and associated with an increased risk of death (hazards ratio, 1.64; 95% CI, 1.21-2.23) among HIV-positive women.

Original languageEnglish (US)
Pages (from-to)260-266
Number of pages7
JournalClinical Infectious Diseases
Volume34
Issue number2
DOIs
StatePublished - Jan 15 2002

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Multicenter Studies
Anemia
Cohort Studies
HIV
Confidence Intervals
Odds Ratio
Incidence
Oral Candidiasis
Zidovudine
CD4 Lymphocyte Count
African Americans
Longitudinal Studies
Pneumonia
Body Mass Index
Fever

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Prevalence and cumulative incidence of and risk factors for anemia in a multicenter cohort study of human immunodeficiency virus-infected and -uninfected women. / Semba, Richard D.; Klein, Robert S.; Mayer, Kenneth H.; Schuman, Paula; Vlahov, David; Klein, Robert S.; Schoenbaum, Ellie; Arnsten, Julia H.; Burk, Robert D.; Chang, Chee Jen; Demas, Penelope; Howard, Andrea; Schuman, Paula; Sobel, Jack; Rompalo, Anne; Vlahov, David; Celentano, David; Shah, Nina; Carpenter, Charles; Mayer, Kenneth; Cu-Uvin, Susan; Flanigan, Timothy; Hogan, Joseph; Stone, Valerie; Tashima, Karen; Rich, Josiah; Duerr, Ann; Gardner, Lytt I.; Heilig, Chad; Holmberg, Scott D.; Jamieson, Denise J.; Moore, Janet S.; Phelps, Ruby M.; Smith, Dawn K.; Warren, Dora; Davenny, Katherine.

In: Clinical Infectious Diseases, Vol. 34, No. 2, 15.01.2002, p. 260-266.

Research output: Contribution to journalArticle

Semba, RD, Klein, RS, Mayer, KH, Schuman, P, Vlahov, D, Klein, RS, Schoenbaum, E, Arnsten, JH, Burk, RD, Chang, CJ, Demas, P, Howard, A, Schuman, P, Sobel, J, Rompalo, A, Vlahov, D, Celentano, D, Shah, N, Carpenter, C, Mayer, K, Cu-Uvin, S, Flanigan, T, Hogan, J, Stone, V, Tashima, K, Rich, J, Duerr, A, Gardner, LI, Heilig, C, Holmberg, SD, Jamieson, DJ, Moore, JS, Phelps, RM, Smith, DK, Warren, D & Davenny, K 2002, 'Prevalence and cumulative incidence of and risk factors for anemia in a multicenter cohort study of human immunodeficiency virus-infected and -uninfected women', Clinical Infectious Diseases, vol. 34, no. 2, pp. 260-266. https://doi.org/10.1086/338151
Semba, Richard D. ; Klein, Robert S. ; Mayer, Kenneth H. ; Schuman, Paula ; Vlahov, David ; Klein, Robert S. ; Schoenbaum, Ellie ; Arnsten, Julia H. ; Burk, Robert D. ; Chang, Chee Jen ; Demas, Penelope ; Howard, Andrea ; Schuman, Paula ; Sobel, Jack ; Rompalo, Anne ; Vlahov, David ; Celentano, David ; Shah, Nina ; Carpenter, Charles ; Mayer, Kenneth ; Cu-Uvin, Susan ; Flanigan, Timothy ; Hogan, Joseph ; Stone, Valerie ; Tashima, Karen ; Rich, Josiah ; Duerr, Ann ; Gardner, Lytt I. ; Heilig, Chad ; Holmberg, Scott D. ; Jamieson, Denise J. ; Moore, Janet S. ; Phelps, Ruby M. ; Smith, Dawn K. ; Warren, Dora ; Davenny, Katherine. / Prevalence and cumulative incidence of and risk factors for anemia in a multicenter cohort study of human immunodeficiency virus-infected and -uninfected women. In: Clinical Infectious Diseases. 2002 ; Vol. 34, No. 2. pp. 260-266.
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AU - Gardner, Lytt I.

AU - Heilig, Chad

AU - Holmberg, Scott D.

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