Pretreatment financial toxicity predicts progression-free survival following concurrent chemoradiotherapy for locally advanced non-small-cell lung cancer

Research output: Contribution to journalArticle

Abstract

Aim: Financial toxicity (FT) describes patients' burden from out-of-pocket medical treatment costs. We studied associations between patient-reported pretreatment FT, socioeconomic status and clinical outcomes for locally advanced non-small-cell lung cancer (LA-NSCLC) patients. Methods: Patients received chemoradiotherapy for locally advanced non-small-cell lung cancer and completed the European Organization for the Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) quality of life assessment before treatment. One question asks whether patients experience financial difficulties'. We tested FT and socioeconomic status (SES) as predictors of progression-free survival (PFS) and overall survival (OS). Results: A total of 43 patients were included. Median follow-up for surviving patients was 15 months. A total of 19 patients (44%) experienced disease progression and 17 patients (40%) died. Increasing FT was associated with shorter PFS (p = 0.011). FT did not predict overall survival (p = 0.67). Conclusion: Higher pretreatment FT is associated with shorter PFS.

Original languageEnglish (US)
Pages (from-to)1697-1705
Number of pages9
JournalFuture Oncology
Volume15
Issue number15
DOIs
StatePublished - May 2019

Keywords

  • chemoradiotherapy
  • chemotherapy
  • financial toxicity
  • lung cancer
  • non-small-cell lung cancer
  • quality of life
  • radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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