TY - JOUR
T1 - Preoperative Pulmonary Hypertension Is Associated with Postoperative Left Ventricular Dysfunction in Chronic Organic Mitral Regurgitation
T2 - An Echocardiographic and Hemodynamic Study
AU - Yang, Hua
AU - Davidson, William R.
AU - Chambers, Charles E.
AU - Pae, Walter E.
AU - Sun, Benjamin
AU - Campbell, David B.
AU - Pu, Min
N1 - Funding Information:
Supported in part by a grant-in-aid from the American Society of Echocardiography, a Scientists Development Grant from the American Heart Association, and the General Clinic Research Center (National Institutes of Health) (Dr Pu).
PY - 2006/8
Y1 - 2006/8
N2 - Background: Some degree of pulmonary hypertension (PHTN) is common in patients with chronic mitral regurgitation. The aim of this study was to determine whether preoperative PHTN is associated with postoperative left ventricular (LV) dysfunction. Methods: The study included 79 patients with chronic organic mitral regurgitation. Preoperative and postoperative LV function was assessed by echocardiography. Preoperative and postoperative hemodynamics were evaluated by a pulmonary artery catheter. Results: Pulmonary artery systolic pressure decreased postoperatively (pre 49 ± 14 vs. post 36 ± 11 mm Hg, P < .01). Postoperative LV ejection fraction was significantly reduced in patients with preoperative PHTN (pre 61 ± 11% vs post 49 ± 12%, P < .01). A stepwise multivariate regression analysis showed that preoperative pulmonary artery systolic pressure and LV end-systolic dimension were independent predictors of postoperative LV ejection fraction (r = -0.53, P < .001, and r = -0.34, P < .05, respectively). Conclusion: Preoperative PHTN is associated with postoperative LV dysfunction in patients with chronic organic mitral regurgitation undergoing mitral valve operation.
AB - Background: Some degree of pulmonary hypertension (PHTN) is common in patients with chronic mitral regurgitation. The aim of this study was to determine whether preoperative PHTN is associated with postoperative left ventricular (LV) dysfunction. Methods: The study included 79 patients with chronic organic mitral regurgitation. Preoperative and postoperative LV function was assessed by echocardiography. Preoperative and postoperative hemodynamics were evaluated by a pulmonary artery catheter. Results: Pulmonary artery systolic pressure decreased postoperatively (pre 49 ± 14 vs. post 36 ± 11 mm Hg, P < .01). Postoperative LV ejection fraction was significantly reduced in patients with preoperative PHTN (pre 61 ± 11% vs post 49 ± 12%, P < .01). A stepwise multivariate regression analysis showed that preoperative pulmonary artery systolic pressure and LV end-systolic dimension were independent predictors of postoperative LV ejection fraction (r = -0.53, P < .001, and r = -0.34, P < .05, respectively). Conclusion: Preoperative PHTN is associated with postoperative LV dysfunction in patients with chronic organic mitral regurgitation undergoing mitral valve operation.
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U2 - 10.1016/j.echo.2006.03.016
DO - 10.1016/j.echo.2006.03.016
M3 - Article
C2 - 16880102
AN - SCOPUS:33746351355
SN - 0894-7317
VL - 19
SP - 1051
EP - 1055
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 8
ER -