Preoperative prediction of postoperative respiratory outcome: Coronary artery bypass grafting

Simon D. Spivack, Tamotsu Shinozaki, John J. Albertini, Robert Deane

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Objective: The hypothesis that traditionally defined preoperative risk factors predict prolonged mechanical ventilation after coronary artery bypass graft surgery (CABG) was tested in our cohort. The predictive power of these factors was quantified, and specific patient subsets destined for prolonged mechanical ventilation after CABG surgery were defined. Design: Five hundred thirteen consecutive patients undergoing CABG were prospectively evaluated. Preoperative pulmonary evaluation included clinical historic data, standard spirometry, and arterial blood gas. Preoperative cardiac parameters included clinical parameters and left ventricular function assessment. Nonthoracic organ (renal, endocrine, pancreas, liver) function was assessed. Setting: University-based, tertiary, referral center. Interventions: None (observational only). Outcomes measured: Duration of mechanical ventilation, duration of surgical ICU stay, and mortality. Results: Multivariate regression analyses revealed that for the patient undergoing routine elective surgery and the patient undergoing urgent surgery, prolonged mechanical ventilation and death were rare events (8.3% and 2.0%, respectively). The combination of reduced left ventricular ejection fraction and the presence of selected preexisting comorbid conditions (clinical congestive heart failure, angina, current smoking, diabetes) served as modest risk factors for prolonged mechanical ventilation; their absence strongly predicted an uncomplicated postoperative respiratory course. No pulmonary diagnosis, mechanical lung function, or blood gas parameter substantially contributed to predicting adverse outcome. Classification and regression tree subgroup analysis refined specific factors important in specific subgroups. Conclusion: With the exception of left ventricular ejection fraction, no preoperative factors emerge as good predictors across all subgroups. This series suggests that pulmonary diagnosis, lung mechanics, and blood gas parameters do not offer the clinician global rules in predicting postoperative respiratory outcome, nor should they be used as exclusion criteria for CABG surgery.

Original languageEnglish (US)
Pages (from-to)1222-1230
Number of pages9
JournalChest
Volume109
Issue number5
StatePublished - 1996
Externally publishedYes

Fingerprint

Artificial Respiration
Coronary Artery Bypass
Lung
Transplants
Gases
Stroke Volume
Preexisting Condition Coverage
Spirometry
Mechanics
Islets of Langerhans
Left Ventricular Function
Tertiary Care Centers
Multivariate Analysis
Heart Failure
Smoking
Regression Analysis
Kidney
Mortality
Liver

Keywords

  • chronic obstructive pulmonary disease (COPD)
  • clinical decision- making
  • clinical risk assessment
  • coronary artery bypass graft surgery (CABG)
  • hypercarbia
  • intensive care
  • left ventricular failure
  • mechanical ventilation
  • postoperative complications
  • preoperative evaluation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Spivack, S. D., Shinozaki, T., Albertini, J. J., & Deane, R. (1996). Preoperative prediction of postoperative respiratory outcome: Coronary artery bypass grafting. Chest, 109(5), 1222-1230.

Preoperative prediction of postoperative respiratory outcome : Coronary artery bypass grafting. / Spivack, Simon D.; Shinozaki, Tamotsu; Albertini, John J.; Deane, Robert.

In: Chest, Vol. 109, No. 5, 1996, p. 1222-1230.

Research output: Contribution to journalArticle

Spivack, SD, Shinozaki, T, Albertini, JJ & Deane, R 1996, 'Preoperative prediction of postoperative respiratory outcome: Coronary artery bypass grafting', Chest, vol. 109, no. 5, pp. 1222-1230.
Spivack, Simon D. ; Shinozaki, Tamotsu ; Albertini, John J. ; Deane, Robert. / Preoperative prediction of postoperative respiratory outcome : Coronary artery bypass grafting. In: Chest. 1996 ; Vol. 109, No. 5. pp. 1222-1230.
@article{efc83bd3889848fc95b92ef65cd2c30b,
title = "Preoperative prediction of postoperative respiratory outcome: Coronary artery bypass grafting",
abstract = "Objective: The hypothesis that traditionally defined preoperative risk factors predict prolonged mechanical ventilation after coronary artery bypass graft surgery (CABG) was tested in our cohort. The predictive power of these factors was quantified, and specific patient subsets destined for prolonged mechanical ventilation after CABG surgery were defined. Design: Five hundred thirteen consecutive patients undergoing CABG were prospectively evaluated. Preoperative pulmonary evaluation included clinical historic data, standard spirometry, and arterial blood gas. Preoperative cardiac parameters included clinical parameters and left ventricular function assessment. Nonthoracic organ (renal, endocrine, pancreas, liver) function was assessed. Setting: University-based, tertiary, referral center. Interventions: None (observational only). Outcomes measured: Duration of mechanical ventilation, duration of surgical ICU stay, and mortality. Results: Multivariate regression analyses revealed that for the patient undergoing routine elective surgery and the patient undergoing urgent surgery, prolonged mechanical ventilation and death were rare events (8.3{\%} and 2.0{\%}, respectively). The combination of reduced left ventricular ejection fraction and the presence of selected preexisting comorbid conditions (clinical congestive heart failure, angina, current smoking, diabetes) served as modest risk factors for prolonged mechanical ventilation; their absence strongly predicted an uncomplicated postoperative respiratory course. No pulmonary diagnosis, mechanical lung function, or blood gas parameter substantially contributed to predicting adverse outcome. Classification and regression tree subgroup analysis refined specific factors important in specific subgroups. Conclusion: With the exception of left ventricular ejection fraction, no preoperative factors emerge as good predictors across all subgroups. This series suggests that pulmonary diagnosis, lung mechanics, and blood gas parameters do not offer the clinician global rules in predicting postoperative respiratory outcome, nor should they be used as exclusion criteria for CABG surgery.",
keywords = "chronic obstructive pulmonary disease (COPD), clinical decision- making, clinical risk assessment, coronary artery bypass graft surgery (CABG), hypercarbia, intensive care, left ventricular failure, mechanical ventilation, postoperative complications, preoperative evaluation",
author = "Spivack, {Simon D.} and Tamotsu Shinozaki and Albertini, {John J.} and Robert Deane",
year = "1996",
language = "English (US)",
volume = "109",
pages = "1222--1230",
journal = "Chest",
issn = "0012-3692",
publisher = "American College of Chest Physicians",
number = "5",

}

TY - JOUR

T1 - Preoperative prediction of postoperative respiratory outcome

T2 - Coronary artery bypass grafting

AU - Spivack, Simon D.

AU - Shinozaki, Tamotsu

AU - Albertini, John J.

AU - Deane, Robert

PY - 1996

Y1 - 1996

N2 - Objective: The hypothesis that traditionally defined preoperative risk factors predict prolonged mechanical ventilation after coronary artery bypass graft surgery (CABG) was tested in our cohort. The predictive power of these factors was quantified, and specific patient subsets destined for prolonged mechanical ventilation after CABG surgery were defined. Design: Five hundred thirteen consecutive patients undergoing CABG were prospectively evaluated. Preoperative pulmonary evaluation included clinical historic data, standard spirometry, and arterial blood gas. Preoperative cardiac parameters included clinical parameters and left ventricular function assessment. Nonthoracic organ (renal, endocrine, pancreas, liver) function was assessed. Setting: University-based, tertiary, referral center. Interventions: None (observational only). Outcomes measured: Duration of mechanical ventilation, duration of surgical ICU stay, and mortality. Results: Multivariate regression analyses revealed that for the patient undergoing routine elective surgery and the patient undergoing urgent surgery, prolonged mechanical ventilation and death were rare events (8.3% and 2.0%, respectively). The combination of reduced left ventricular ejection fraction and the presence of selected preexisting comorbid conditions (clinical congestive heart failure, angina, current smoking, diabetes) served as modest risk factors for prolonged mechanical ventilation; their absence strongly predicted an uncomplicated postoperative respiratory course. No pulmonary diagnosis, mechanical lung function, or blood gas parameter substantially contributed to predicting adverse outcome. Classification and regression tree subgroup analysis refined specific factors important in specific subgroups. Conclusion: With the exception of left ventricular ejection fraction, no preoperative factors emerge as good predictors across all subgroups. This series suggests that pulmonary diagnosis, lung mechanics, and blood gas parameters do not offer the clinician global rules in predicting postoperative respiratory outcome, nor should they be used as exclusion criteria for CABG surgery.

AB - Objective: The hypothesis that traditionally defined preoperative risk factors predict prolonged mechanical ventilation after coronary artery bypass graft surgery (CABG) was tested in our cohort. The predictive power of these factors was quantified, and specific patient subsets destined for prolonged mechanical ventilation after CABG surgery were defined. Design: Five hundred thirteen consecutive patients undergoing CABG were prospectively evaluated. Preoperative pulmonary evaluation included clinical historic data, standard spirometry, and arterial blood gas. Preoperative cardiac parameters included clinical parameters and left ventricular function assessment. Nonthoracic organ (renal, endocrine, pancreas, liver) function was assessed. Setting: University-based, tertiary, referral center. Interventions: None (observational only). Outcomes measured: Duration of mechanical ventilation, duration of surgical ICU stay, and mortality. Results: Multivariate regression analyses revealed that for the patient undergoing routine elective surgery and the patient undergoing urgent surgery, prolonged mechanical ventilation and death were rare events (8.3% and 2.0%, respectively). The combination of reduced left ventricular ejection fraction and the presence of selected preexisting comorbid conditions (clinical congestive heart failure, angina, current smoking, diabetes) served as modest risk factors for prolonged mechanical ventilation; their absence strongly predicted an uncomplicated postoperative respiratory course. No pulmonary diagnosis, mechanical lung function, or blood gas parameter substantially contributed to predicting adverse outcome. Classification and regression tree subgroup analysis refined specific factors important in specific subgroups. Conclusion: With the exception of left ventricular ejection fraction, no preoperative factors emerge as good predictors across all subgroups. This series suggests that pulmonary diagnosis, lung mechanics, and blood gas parameters do not offer the clinician global rules in predicting postoperative respiratory outcome, nor should they be used as exclusion criteria for CABG surgery.

KW - chronic obstructive pulmonary disease (COPD)

KW - clinical decision- making

KW - clinical risk assessment

KW - coronary artery bypass graft surgery (CABG)

KW - hypercarbia

KW - intensive care

KW - left ventricular failure

KW - mechanical ventilation

KW - postoperative complications

KW - preoperative evaluation

UR - http://www.scopus.com/inward/record.url?scp=0029966592&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029966592&partnerID=8YFLogxK

M3 - Article

C2 - 8625671

AN - SCOPUS:0029966592

VL - 109

SP - 1222

EP - 1230

JO - Chest

JF - Chest

SN - 0012-3692

IS - 5

ER -