Preliminary results with sutured colonic anastomoses reinforced with dye-enhanced fibrinogen and a diode laser

Steven K. Libutti, Mathew R. Williams, Mehmet C. Oz, Kenneth A. Forde, Lawrence S. Bass, Samuel Weinstein, Joseph S. Auteri, Michael R. Treat, Roman Nowygrod

Research output: Contribution to journalConference articlepeer-review

3 Scopus citations


A common cause of morbidity in patients recovering from bowel surgery is leakage from colonic anastomoses. We evaluated a technique utilizing a laser activated protein solder to strengthen colonic anastomoses in a canine model. Following creation of six single-layer interrupted suture anastomoses in four dogs, a protein solder consisting of indocyanine green dye and fibrinogen was topically applied to the serosal surface and exposed to 808 nm continuous wave diode laser energy. Immediately following anastomosis, the mean leakage pressure of sutures alone was 129 ± 14 mm hg (n=6), while the mean leakage pressure of sutures reinforced with the laser welded solder was 312 ± 32 mm hg (n=6) (p<0.001). Histologic examination of sections take through the anastomosis demonstrated a layer of fibrinogen across the anastomotic gap without evidence of thermal injury. Laser activated protein solder significantly enhances the immediate strength of sutured colonic anastomoses without causing appreciable thermal injury to surrounding tissues.

Original languageEnglish (US)
Pages (from-to)169-172
Number of pages4
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Jan 1 1991
EventProceedings of Lasers in Urology, Laparoscopy, and General Surgery - Los Angeles, CA, USA
Duration: Jan 21 1991Jan 23 1991

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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