TY - JOUR
T1 - Prefrontal and midline interactions mediating behavioural control
AU - Fassbender, Catherine
AU - Hester, Robert
AU - Murphy, Kevin
AU - Foxe, John J.
AU - Foxe, Deirdre M.
AU - Garavan, Hugh
PY - 2009/1
Y1 - 2009/1
N2 - Top-down control processes are thought to interact with bottom-up stimulus-driven task demands to facilitate the smooth execution of behaviour. Frontal and midline brain areas in humans are believed to subserve these control processes but their distinct roles and the interactions between them remain to be fully elucidated. In this functional magnetic resonance imaging (fMRI) study, we utilized a GO/NO-GO task with cued and uncued inhibitory events to investigate the effect of cue-induced levels of top-down control on NO-GO trial response conflict. We found that, on a within-subjects, trial-for-trial basis, high levels of top-down control, as indexed by left dorsolateral prefrontal activation prior to the NO-GO, resulted in lower levels of activation on the NO-GO trial in the pre-supplementary motor area. These results suggest that prefrontal and midline regions work together to implement cognitive control and reveal that intra-subject variability is reflected in these lateral and midline interactions.
AB - Top-down control processes are thought to interact with bottom-up stimulus-driven task demands to facilitate the smooth execution of behaviour. Frontal and midline brain areas in humans are believed to subserve these control processes but their distinct roles and the interactions between them remain to be fully elucidated. In this functional magnetic resonance imaging (fMRI) study, we utilized a GO/NO-GO task with cued and uncued inhibitory events to investigate the effect of cue-induced levels of top-down control on NO-GO trial response conflict. We found that, on a within-subjects, trial-for-trial basis, high levels of top-down control, as indexed by left dorsolateral prefrontal activation prior to the NO-GO, resulted in lower levels of activation on the NO-GO trial in the pre-supplementary motor area. These results suggest that prefrontal and midline regions work together to implement cognitive control and reveal that intra-subject variability is reflected in these lateral and midline interactions.
KW - Anterior cingulate cortex
KW - Cognitive control
KW - Dorsolateral prefrontal cortex
KW - Human
KW - Pre-supplementary motor area
KW - fMRI
UR - http://www.scopus.com/inward/record.url?scp=58149127363&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149127363&partnerID=8YFLogxK
U2 - 10.1111/j.1460-9568.2008.06557.x
DO - 10.1111/j.1460-9568.2008.06557.x
M3 - Article
C2 - 19120444
AN - SCOPUS:58149127363
SN - 0953-816X
VL - 29
SP - 181
EP - 187
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
IS - 1
ER -