Predicting the likelihood of nonsentinel lymph node metastases in triple negative breast cancer patients with a positive sentinel lymph node: Turkish federation of breast disease associations protocol MF09-01

Serdar Ozbas, Vahit Ozmen, Abdullah Igci, Mahmut Muslumanoglu, Beyza Ozcinar, Mujdat Balkan, Fatih Aydogan, Tulay Canda, Omer Harmancioglu, Erol Aksaz, Bahadir M. Gulluoglu, Munire Kayahan, Cihangir Ozaslan, N. Zafer Canturk, Hakan Mersin, Zafer Utkan, Savas Kocak, Nalan Ulufi, Ayfer Kamali Polat, Oya AndacogluAtilla Soran

Research output: Contribution to journalArticle

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Abstract

Background: Triple negative (TN) tumor has a relatively high rate of recurrence and distant metastasis, but results of studies revealed that triple positive tumor is an independent predictor of axillary lymph node involvement. Our aim was to evaluate the frequency of nonsentinel lymph node metastasis (NSLNM) involvement in operable TN breast cancer with positive sentinel lymph node (SLN) and predicting the likelihood of NSLNM in this cohort of patients by using 4 different nomograms. Methods: A total of 128 patients with TN and SLN+ underwent complete axillary lymph node dissection in 14 different centers in Turkey. For comparison, we used our previous multicenter MF08-01 Protocol, which identified 441 patients with estrogen receptor (ER +) who had a positive SLN biopsy and underwent subsequent complete axillary lymph node dissection. Turkish, Cambridge, and Stanford nomograms and the Tenon Score system were used to calculate the probability of NSLNM. Results: Patients with TN tumor had a larger tumor size. The actual percentage of NSLN positivity was 41% in the TN group and 47.1% in patient with ER+. The Tenon Score was ≤3.5 in 12% of patients with TN and ER+; the area under the curve in the receiver operating characteristics curve were 0.53 and 0.59, respectively. Based on the Turkish, Cambridge, and Stanford nomograms, areas under the curve were 0.54, 0.53, and 0.61, respectively in patients with TN, and were 0.79, 0.72, and 0.70, respectively, in patients with ER +. Conclusion: Using the Tenon Score system underestimates NSLN positivity, and tested nomograms are not good discriminators of NSLNM in patients with TN and positive SLN.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalClinical breast cancer
Volume12
Issue number1
DOIs
StatePublished - Feb 2012
Externally publishedYes

Fingerprint

Triple Negative Breast Neoplasms
Breast Diseases
Lymph Nodes
Neoplasm Metastasis
Nomograms
Lymph Node Excision
Area Under Curve
Neoplasms
Sentinel Lymph Node
Sentinel Lymph Node Biopsy
Turkey
ROC Curve
Estrogen Receptors
Recurrence

Keywords

  • Breast carcinoma
  • Nomogram
  • Nonsentinel lymph node
  • Sentinel lymph node
  • Triple negative

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Predicting the likelihood of nonsentinel lymph node metastases in triple negative breast cancer patients with a positive sentinel lymph node : Turkish federation of breast disease associations protocol MF09-01. / Ozbas, Serdar; Ozmen, Vahit; Igci, Abdullah; Muslumanoglu, Mahmut; Ozcinar, Beyza; Balkan, Mujdat; Aydogan, Fatih; Canda, Tulay; Harmancioglu, Omer; Aksaz, Erol; Gulluoglu, Bahadir M.; Kayahan, Munire; Ozaslan, Cihangir; Canturk, N. Zafer; Mersin, Hakan; Utkan, Zafer; Kocak, Savas; Ulufi, Nalan; Polat, Ayfer Kamali; Andacoglu, Oya; Soran, Atilla.

In: Clinical breast cancer, Vol. 12, No. 1, 02.2012, p. 63-67.

Research output: Contribution to journalArticle

Ozbas, S, Ozmen, V, Igci, A, Muslumanoglu, M, Ozcinar, B, Balkan, M, Aydogan, F, Canda, T, Harmancioglu, O, Aksaz, E, Gulluoglu, BM, Kayahan, M, Ozaslan, C, Canturk, NZ, Mersin, H, Utkan, Z, Kocak, S, Ulufi, N, Polat, AK, Andacoglu, O & Soran, A 2012, 'Predicting the likelihood of nonsentinel lymph node metastases in triple negative breast cancer patients with a positive sentinel lymph node: Turkish federation of breast disease associations protocol MF09-01', Clinical breast cancer, vol. 12, no. 1, pp. 63-67. https://doi.org/10.1016/j.clbc.2011.07.004
Ozbas, Serdar ; Ozmen, Vahit ; Igci, Abdullah ; Muslumanoglu, Mahmut ; Ozcinar, Beyza ; Balkan, Mujdat ; Aydogan, Fatih ; Canda, Tulay ; Harmancioglu, Omer ; Aksaz, Erol ; Gulluoglu, Bahadir M. ; Kayahan, Munire ; Ozaslan, Cihangir ; Canturk, N. Zafer ; Mersin, Hakan ; Utkan, Zafer ; Kocak, Savas ; Ulufi, Nalan ; Polat, Ayfer Kamali ; Andacoglu, Oya ; Soran, Atilla. / Predicting the likelihood of nonsentinel lymph node metastases in triple negative breast cancer patients with a positive sentinel lymph node : Turkish federation of breast disease associations protocol MF09-01. In: Clinical breast cancer. 2012 ; Vol. 12, No. 1. pp. 63-67.
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abstract = "Background: Triple negative (TN) tumor has a relatively high rate of recurrence and distant metastasis, but results of studies revealed that triple positive tumor is an independent predictor of axillary lymph node involvement. Our aim was to evaluate the frequency of nonsentinel lymph node metastasis (NSLNM) involvement in operable TN breast cancer with positive sentinel lymph node (SLN) and predicting the likelihood of NSLNM in this cohort of patients by using 4 different nomograms. Methods: A total of 128 patients with TN and SLN+ underwent complete axillary lymph node dissection in 14 different centers in Turkey. For comparison, we used our previous multicenter MF08-01 Protocol, which identified 441 patients with estrogen receptor (ER +) who had a positive SLN biopsy and underwent subsequent complete axillary lymph node dissection. Turkish, Cambridge, and Stanford nomograms and the Tenon Score system were used to calculate the probability of NSLNM. Results: Patients with TN tumor had a larger tumor size. The actual percentage of NSLN positivity was 41{\%} in the TN group and 47.1{\%} in patient with ER+. The Tenon Score was ≤3.5 in 12{\%} of patients with TN and ER+; the area under the curve in the receiver operating characteristics curve were 0.53 and 0.59, respectively. Based on the Turkish, Cambridge, and Stanford nomograms, areas under the curve were 0.54, 0.53, and 0.61, respectively in patients with TN, and were 0.79, 0.72, and 0.70, respectively, in patients with ER +. Conclusion: Using the Tenon Score system underestimates NSLN positivity, and tested nomograms are not good discriminators of NSLNM in patients with TN and positive SLN.",
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T1 - Predicting the likelihood of nonsentinel lymph node metastases in triple negative breast cancer patients with a positive sentinel lymph node

T2 - Turkish federation of breast disease associations protocol MF09-01

AU - Ozbas, Serdar

AU - Ozmen, Vahit

AU - Igci, Abdullah

AU - Muslumanoglu, Mahmut

AU - Ozcinar, Beyza

AU - Balkan, Mujdat

AU - Aydogan, Fatih

AU - Canda, Tulay

AU - Harmancioglu, Omer

AU - Aksaz, Erol

AU - Gulluoglu, Bahadir M.

AU - Kayahan, Munire

AU - Ozaslan, Cihangir

AU - Canturk, N. Zafer

AU - Mersin, Hakan

AU - Utkan, Zafer

AU - Kocak, Savas

AU - Ulufi, Nalan

AU - Polat, Ayfer Kamali

AU - Andacoglu, Oya

AU - Soran, Atilla

PY - 2012/2

Y1 - 2012/2

N2 - Background: Triple negative (TN) tumor has a relatively high rate of recurrence and distant metastasis, but results of studies revealed that triple positive tumor is an independent predictor of axillary lymph node involvement. Our aim was to evaluate the frequency of nonsentinel lymph node metastasis (NSLNM) involvement in operable TN breast cancer with positive sentinel lymph node (SLN) and predicting the likelihood of NSLNM in this cohort of patients by using 4 different nomograms. Methods: A total of 128 patients with TN and SLN+ underwent complete axillary lymph node dissection in 14 different centers in Turkey. For comparison, we used our previous multicenter MF08-01 Protocol, which identified 441 patients with estrogen receptor (ER +) who had a positive SLN biopsy and underwent subsequent complete axillary lymph node dissection. Turkish, Cambridge, and Stanford nomograms and the Tenon Score system were used to calculate the probability of NSLNM. Results: Patients with TN tumor had a larger tumor size. The actual percentage of NSLN positivity was 41% in the TN group and 47.1% in patient with ER+. The Tenon Score was ≤3.5 in 12% of patients with TN and ER+; the area under the curve in the receiver operating characteristics curve were 0.53 and 0.59, respectively. Based on the Turkish, Cambridge, and Stanford nomograms, areas under the curve were 0.54, 0.53, and 0.61, respectively in patients with TN, and were 0.79, 0.72, and 0.70, respectively, in patients with ER +. Conclusion: Using the Tenon Score system underestimates NSLN positivity, and tested nomograms are not good discriminators of NSLNM in patients with TN and positive SLN.

AB - Background: Triple negative (TN) tumor has a relatively high rate of recurrence and distant metastasis, but results of studies revealed that triple positive tumor is an independent predictor of axillary lymph node involvement. Our aim was to evaluate the frequency of nonsentinel lymph node metastasis (NSLNM) involvement in operable TN breast cancer with positive sentinel lymph node (SLN) and predicting the likelihood of NSLNM in this cohort of patients by using 4 different nomograms. Methods: A total of 128 patients with TN and SLN+ underwent complete axillary lymph node dissection in 14 different centers in Turkey. For comparison, we used our previous multicenter MF08-01 Protocol, which identified 441 patients with estrogen receptor (ER +) who had a positive SLN biopsy and underwent subsequent complete axillary lymph node dissection. Turkish, Cambridge, and Stanford nomograms and the Tenon Score system were used to calculate the probability of NSLNM. Results: Patients with TN tumor had a larger tumor size. The actual percentage of NSLN positivity was 41% in the TN group and 47.1% in patient with ER+. The Tenon Score was ≤3.5 in 12% of patients with TN and ER+; the area under the curve in the receiver operating characteristics curve were 0.53 and 0.59, respectively. Based on the Turkish, Cambridge, and Stanford nomograms, areas under the curve were 0.54, 0.53, and 0.61, respectively in patients with TN, and were 0.79, 0.72, and 0.70, respectively, in patients with ER +. Conclusion: Using the Tenon Score system underestimates NSLN positivity, and tested nomograms are not good discriminators of NSLNM in patients with TN and positive SLN.

KW - Breast carcinoma

KW - Nomogram

KW - Nonsentinel lymph node

KW - Sentinel lymph node

KW - Triple negative

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