Predicting success: Patterns of cortical activation and deactivation prior to response inhibition

Robert L. Hester, Kevin Murphy, John J. Foxe, Deirdre M. Foxe, Daniel C. Javitt, Hugh Garavan

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

The present study investigated the relationships between attention and other preparatory processes prior to a response inhibition task and the processes involved in the inhibition itself. To achieve this, a mixed fMRI design was employed to identify the functional areas activated during both inhibition decision events and the block of trials following a visual cue introduced 2 to 7 sec prior (cue period). Preparing for successful performance produced increases in activation for both the cue period and the inhibition itself in the frontoparietal cortical network. Furthermore, preparation produced activation decreases in midline areas (insula and medial prefrontal) argued to be responsible for monitoring internal emotional states, and these cue period deactivations alone predicted subsequent success or failure. The results suggest that when cues are provided to signify the imminent requirement for behavioral control, successful performance results from a coordinated pattern of preparatory activation in task-relevant areas and deactivation of task-irrelevant ones.

Original languageEnglish (US)
Pages (from-to)776-785
Number of pages10
JournalJournal of Cognitive Neuroscience
Volume16
Issue number5
DOIs
StatePublished - Jun 1 2004

    Fingerprint

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this