TY - JOUR
T1 - Predicting renal functional outcomes after surgery for renal cortical tumours
T2 - A multifactorial analysis
AU - Barlow, Lamont J.
AU - Korets, Ruslan
AU - Laudano, Melissa
AU - Benson, Mitchell
AU - McKiernan, James
PY - 2010/8
Y1 - 2010/8
N2 - Study Type - Therapy (case series) Level of Evidence 4 Objective: To examine the functional outcomes after radical (RN) and partial nephrectomy (PN) stratified by variables before and after surgery, using estimated glomerular filtration rate (eGFR), as nephrectomy is the standard treatment for localized renal tumours, but the risk of developing chronic kidney disease (CKD) increases after surgery. Patients and Methods: We retrospectively analysed patients treated with PN or RN for renal cancer at one institution from 1988 to 2008. Chronic renal function before and after surgery was measured using the eGFR computed using the Modification of Diet in Renal Disease equation. Four outcomes were measured: (i) presence of new-onset renal insufficiency (eGFR <60 mL/min/1.73m2); (ii) the percentage change in eGFR; (iii) the change in CKD stage; and (iv) the presence of CKD upstaging. Regression models were used to determine the effect of surgical procedure (RN vs PN), access technique (open vs laparoscopic) and several preoperative characteristics on functional outcomes. Results: In all, 276 patients met the inclusion criteria (174 RN and 102 PN) of whom 209 had a preoperative eGFR of >60 mL/min/1.73m2. After ≥3 months from surgery, 108/209 (52%) patients developed new-onset eGFR of <60 mL/min/1.73m2. On multivariate analysis, preoperative CKD stage (P < 0.001) and procedure (P = 0.001) were both independent predictors of all four functional outcomes measured. Also, hypertension was an independent predictor of CKD upstaging (P = 0.02). Surgical access technique was not an independent predictor of any of the renal functional outcomes measured. CONCLUSION Patients undergoing renal surgery have a high rate of new-onset CKD afterward. After controlling for preoperative risk factors, patients undergoing RN are at greater risk of a decline in renal function. However, surgical access technique was not a significant predictor for renal impairment. Journal Compilation
AB - Study Type - Therapy (case series) Level of Evidence 4 Objective: To examine the functional outcomes after radical (RN) and partial nephrectomy (PN) stratified by variables before and after surgery, using estimated glomerular filtration rate (eGFR), as nephrectomy is the standard treatment for localized renal tumours, but the risk of developing chronic kidney disease (CKD) increases after surgery. Patients and Methods: We retrospectively analysed patients treated with PN or RN for renal cancer at one institution from 1988 to 2008. Chronic renal function before and after surgery was measured using the eGFR computed using the Modification of Diet in Renal Disease equation. Four outcomes were measured: (i) presence of new-onset renal insufficiency (eGFR <60 mL/min/1.73m2); (ii) the percentage change in eGFR; (iii) the change in CKD stage; and (iv) the presence of CKD upstaging. Regression models were used to determine the effect of surgical procedure (RN vs PN), access technique (open vs laparoscopic) and several preoperative characteristics on functional outcomes. Results: In all, 276 patients met the inclusion criteria (174 RN and 102 PN) of whom 209 had a preoperative eGFR of >60 mL/min/1.73m2. After ≥3 months from surgery, 108/209 (52%) patients developed new-onset eGFR of <60 mL/min/1.73m2. On multivariate analysis, preoperative CKD stage (P < 0.001) and procedure (P = 0.001) were both independent predictors of all four functional outcomes measured. Also, hypertension was an independent predictor of CKD upstaging (P = 0.02). Surgical access technique was not an independent predictor of any of the renal functional outcomes measured. CONCLUSION Patients undergoing renal surgery have a high rate of new-onset CKD afterward. After controlling for preoperative risk factors, patients undergoing RN are at greater risk of a decline in renal function. However, surgical access technique was not a significant predictor for renal impairment. Journal Compilation
KW - glomerular filtration rate
KW - nephrectomy
KW - patient characteristics
KW - renal cell carcinoma
KW - treatment outcome
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U2 - 10.1111/j.1464-410X.2009.09147.x
DO - 10.1111/j.1464-410X.2009.09147.x
M3 - Article
C2 - 20039869
AN - SCOPUS:77955060007
SN - 1464-4096
VL - 106
SP - 489
EP - 492
JO - BJU International
JF - BJU International
IS - 4
ER -
