Potent Antibody Protection against an Emerging Alphavirus Threat

Margaret Kielian; Erica Ollmann Saphire

doi:10.1016/j.cell.2015.11.006

Potent Antibody Protection against an Emerging Alphavirus Threat

Margaret Kielian, Erica Ollmann Saphire

Cell Biology

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization. The Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization.

Original language	English (US)
Pages (from-to)	1053-1054
Number of pages	2
Journal	Cell
Volume	163
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2015.11.006
State	Published - Nov 19 2015

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2015.11.006

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title = "Potent Antibody Protection against an Emerging Alphavirus Threat",

abstract = "Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization. The Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization.",

author = "Margaret Kielian and Saphire, {Erica Ollmann}",

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AU - Saphire, Erica Ollmann

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AB - Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization. The Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization.

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Potent Antibody Protection against an Emerging Alphavirus Threat

Abstract

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