Potent Antibody Protection against an Emerging Alphavirus Threat

Margaret Kielian, Erica Ollmann Saphire

Research output: Contribution to journalShort survey

3 Scopus citations

Abstract

Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization. The Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization.

Original languageEnglish (US)
Pages (from-to)1053-1054
Number of pages2
JournalCell
Volume163
Issue number5
DOIs
StatePublished - Nov 19 2015

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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