Potent Antibody Protection against an Emerging Alphavirus Threat

Margaret Kielian, Erica Ollmann Saphire

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization. The Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization.

Original languageEnglish (US)
Pages (from-to)1053-1054
Number of pages2
JournalCell
Volume163
Issue number5
DOIs
StatePublished - Nov 19 2015

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Alphavirus
Viruses
Chikungunya virus
Viral Structures
Antibodies
Viral Proteins
Neutralizing Antibodies
Crosslinking
Disease Outbreaks
Membrane Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Potent Antibody Protection against an Emerging Alphavirus Threat. / Kielian, Margaret; Saphire, Erica Ollmann.

In: Cell, Vol. 163, No. 5, 19.11.2015, p. 1053-1054.

Research output: Contribution to journalArticle

Kielian, Margaret ; Saphire, Erica Ollmann. / Potent Antibody Protection against an Emerging Alphavirus Threat. In: Cell. 2015 ; Vol. 163, No. 5. pp. 1053-1054.
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