Potassium and glucose measures in older adults

The cardiovascular health study

Ranee Chatterjee, Mary L. Biggs, Ian H. De Boer, Frederick L. Brancati, Laura P. Svetkey, Joshua Barzilay, Luc Djoussé, Joachim H. Ix, Jorge Kizer, David S. Siscovick, Dariush Mozaffarian, David Edelman, Kenneth J. Mukamal

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background. We sought to determine the impacts of serum and dietary potassium measures on glucose metabolism and diabetes risk in older adults. Methods. Among participants of the Cardiovascular Health Study, a community-based cohort of older American adults, we examined a) cross-sectional associations between potassium and measures of insulin sensitivity and secretion estimated from oral glucose tolerance tests and b) longitudinal associations of serum and dietary potassium with diabetes risk. Results. Among 4,754 participants aged ≥65 years at baseline, there were 445 cases of incident diabetes during a median follow-up of 12 years. In multivariate models, baseline serum and dietary potassium were both associated with lower insulin sensitivity and greater insulin secretion. Compared with those with a serum potassium ≥4.5 mEq/L, participants with a serum potassium <4.0mEq/L had an adjusted mean difference in Matsuda insulin sensitivity index of -0.18 (-0.39, 0.02). Compared with those in the highest quartile, participants in the lowest quartile of dietary potassium intake had a corresponding adjusted mean difference in Matsuda insulin sensitivity index of -0.61 (-0.94, -0.29). In multivariate models, neither serum nor dietary potassium intake was associated with long-term diabetes risk. Conclusions. Although we did not identify serum and dietary potassium as risk factors for incident diabetes in older adults, results from cross-sectional analyses suggest that both may be associated with increased insulin resistance. This relationship with insulin resistance needs to be confirmed, and its importance on diabetes risk, cardiovascular risk, and conditions specific to older adults should be determined as well.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume70
Issue number2
DOIs
StatePublished - Feb 1 2015

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Dietary Potassium
Potassium
Insulin Resistance
Glucose
Health
Serum
Glucose Tolerance Test
Cross-Sectional Studies
Insulin

Keywords

  • Glucose metabolism
  • Older adults
  • Potassium

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Chatterjee, R., Biggs, M. L., De Boer, I. H., Brancati, F. L., Svetkey, L. P., Barzilay, J., ... Mukamal, K. J. (2015). Potassium and glucose measures in older adults: The cardiovascular health study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 70(2), 255-261. https://doi.org/10.1093/gerona/glu071

Potassium and glucose measures in older adults : The cardiovascular health study. / Chatterjee, Ranee; Biggs, Mary L.; De Boer, Ian H.; Brancati, Frederick L.; Svetkey, Laura P.; Barzilay, Joshua; Djoussé, Luc; Ix, Joachim H.; Kizer, Jorge; Siscovick, David S.; Mozaffarian, Dariush; Edelman, David; Mukamal, Kenneth J.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 70, No. 2, 01.02.2015, p. 255-261.

Research output: Contribution to journalArticle

Chatterjee, R, Biggs, ML, De Boer, IH, Brancati, FL, Svetkey, LP, Barzilay, J, Djoussé, L, Ix, JH, Kizer, J, Siscovick, DS, Mozaffarian, D, Edelman, D & Mukamal, KJ 2015, 'Potassium and glucose measures in older adults: The cardiovascular health study', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 70, no. 2, pp. 255-261. https://doi.org/10.1093/gerona/glu071
Chatterjee, Ranee ; Biggs, Mary L. ; De Boer, Ian H. ; Brancati, Frederick L. ; Svetkey, Laura P. ; Barzilay, Joshua ; Djoussé, Luc ; Ix, Joachim H. ; Kizer, Jorge ; Siscovick, David S. ; Mozaffarian, Dariush ; Edelman, David ; Mukamal, Kenneth J. / Potassium and glucose measures in older adults : The cardiovascular health study. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2015 ; Vol. 70, No. 2. pp. 255-261.
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AU - Svetkey, Laura P.

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AU - Djoussé, Luc

AU - Ix, Joachim H.

AU - Kizer, Jorge

AU - Siscovick, David S.

AU - Mozaffarian, Dariush

AU - Edelman, David

AU - Mukamal, Kenneth J.

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N2 - Background. We sought to determine the impacts of serum and dietary potassium measures on glucose metabolism and diabetes risk in older adults. Methods. Among participants of the Cardiovascular Health Study, a community-based cohort of older American adults, we examined a) cross-sectional associations between potassium and measures of insulin sensitivity and secretion estimated from oral glucose tolerance tests and b) longitudinal associations of serum and dietary potassium with diabetes risk. Results. Among 4,754 participants aged ≥65 years at baseline, there were 445 cases of incident diabetes during a median follow-up of 12 years. In multivariate models, baseline serum and dietary potassium were both associated with lower insulin sensitivity and greater insulin secretion. Compared with those with a serum potassium ≥4.5 mEq/L, participants with a serum potassium <4.0mEq/L had an adjusted mean difference in Matsuda insulin sensitivity index of -0.18 (-0.39, 0.02). Compared with those in the highest quartile, participants in the lowest quartile of dietary potassium intake had a corresponding adjusted mean difference in Matsuda insulin sensitivity index of -0.61 (-0.94, -0.29). In multivariate models, neither serum nor dietary potassium intake was associated with long-term diabetes risk. Conclusions. Although we did not identify serum and dietary potassium as risk factors for incident diabetes in older adults, results from cross-sectional analyses suggest that both may be associated with increased insulin resistance. This relationship with insulin resistance needs to be confirmed, and its importance on diabetes risk, cardiovascular risk, and conditions specific to older adults should be determined as well.

AB - Background. We sought to determine the impacts of serum and dietary potassium measures on glucose metabolism and diabetes risk in older adults. Methods. Among participants of the Cardiovascular Health Study, a community-based cohort of older American adults, we examined a) cross-sectional associations between potassium and measures of insulin sensitivity and secretion estimated from oral glucose tolerance tests and b) longitudinal associations of serum and dietary potassium with diabetes risk. Results. Among 4,754 participants aged ≥65 years at baseline, there were 445 cases of incident diabetes during a median follow-up of 12 years. In multivariate models, baseline serum and dietary potassium were both associated with lower insulin sensitivity and greater insulin secretion. Compared with those with a serum potassium ≥4.5 mEq/L, participants with a serum potassium <4.0mEq/L had an adjusted mean difference in Matsuda insulin sensitivity index of -0.18 (-0.39, 0.02). Compared with those in the highest quartile, participants in the lowest quartile of dietary potassium intake had a corresponding adjusted mean difference in Matsuda insulin sensitivity index of -0.61 (-0.94, -0.29). In multivariate models, neither serum nor dietary potassium intake was associated with long-term diabetes risk. Conclusions. Although we did not identify serum and dietary potassium as risk factors for incident diabetes in older adults, results from cross-sectional analyses suggest that both may be associated with increased insulin resistance. This relationship with insulin resistance needs to be confirmed, and its importance on diabetes risk, cardiovascular risk, and conditions specific to older adults should be determined as well.

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