Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people

Eliana Romina Meza-Miranda, Antonio Camargo, Oriol Alberto Rangel-Zuñiga, Javier Delgado-Lista, Antonio Garcia-Rios, Pablo Perez-Martinez, Inma Tasset-Cuevas, Isaac Tunez, Francisco J. Tinahones, Francisco Perez-Jimenez, José Lopez-Miranda

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We have investigated whether dietary fat modifies the postprandial oxidative stress in adipose tissue of elderly people. Twenty participants received three diets for 4 weeks each: SFA-rich diet, Mediterranean (Med) diet enriched in MUFA with virgin olive oil, and a low-fat, high-carbohydrate diet enriched in n-3 PUFA (α-linolenic acid from plant origin) (CHO-PUFA diet). After 12 h of fasting, volunteers received a breakfast reflecting the fatty acid composition of the diet ingested in the preceding dietary period. Med diet induced higher postprandial SOD2 and TrxR mRNA levels, and CHO-PUFA diet induced higher GPx1 and TrxR mRNA levels compared with SFA-rich diet. Med and CHO-PUFA breakfasts induced a postprandial increase in plasma reduced glutathione (GSH), and a greater postprandial GSH/oxidized glutathione ratio compared to the SFA-rich diet. Our study suggests that the consumption of Med and CHO-PUFA diets may reduce postprandial oxidative stress compared to an SFA-rich diet, which may be due to higher antioxidant enzymes gene expression in adipose tissue.

Original languageEnglish (US)
Pages (from-to)507-517
Number of pages11
JournalAGE
Volume36
Issue number2
DOIs
StatePublished - Apr 2014
Externally publishedYes

Keywords

  • Aging
  • Dietary fat
  • Metabolic syndrome
  • Oxidative stress
  • Postprandial state

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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    Meza-Miranda, E. R., Camargo, A., Rangel-Zuñiga, O. A., Delgado-Lista, J., Garcia-Rios, A., Perez-Martinez, P., Tasset-Cuevas, I., Tunez, I., Tinahones, F. J., Perez-Jimenez, F., & Lopez-Miranda, J. (2014). Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people. AGE, 36(2), 507-517. https://doi.org/10.1007/s11357-013-9579-y