Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people

Eliana Romina Meza-Miranda, Antonio Camargo, Oriol Alberto Rangel-Zuñiga, Javier Delgado-Lista, Antonio Garcia-Rios, Pablo Perez-Martinez, Inmaculada Tasset, Isaac Tunez, Francisco J. Tinahones, Francisco Perez-Jimenez, José Lopez-Miranda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We have investigated whether dietary fat modifies the postprandial oxidative stress in adipose tissue of elderly people. Twenty participants received three diets for 4 weeks each: SFA-rich diet, Mediterranean (Med) diet enriched in MUFA with virgin olive oil, and a low-fat, high-carbohydrate diet enriched in n-3 PUFA (α-linolenic acid from plant origin) (CHO-PUFA diet). After 12 h of fasting, volunteers received a breakfast reflecting the fatty acid composition of the diet ingested in the preceding dietary period. Med diet induced higher postprandial SOD2 and TrxR mRNA levels, and CHO-PUFA diet induced higher GPx1 and TrxR mRNA levels compared with SFA-rich diet. Med and CHO-PUFA breakfasts induced a postprandial increase in plasma reduced glutathione (GSH), and a greater postprandial GSH/oxidized glutathione ratio compared to the SFA-rich diet. Our study suggests that the consumption of Med and CHO-PUFA diets may reduce postprandial oxidative stress compared to an SFA-rich diet, which may be due to higher antioxidant enzymes gene expression in adipose tissue.

Original languageEnglish (US)
Pages (from-to)507-517
Number of pages11
JournalAge
Volume36
Issue number2
DOIs
StatePublished - 2014
Externally publishedYes

Fingerprint

Dietary Fats
Adipose Tissue
Oxidative Stress
Diet
Mediterranean Diet
Breakfast
Messenger RNA
alpha-Linolenic Acid
Glutathione Disulfide
Omega-3 Fatty Acids
High Fat Diet
Glutathione
Volunteers
Fasting
Fatty Acids
Antioxidants
Carbohydrates
Gene Expression
Enzymes

Keywords

  • Aging
  • Dietary fat
  • Metabolic syndrome
  • Oxidative stress
  • Postprandial state

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Meza-Miranda, E. R., Camargo, A., Rangel-Zuñiga, O. A., Delgado-Lista, J., Garcia-Rios, A., Perez-Martinez, P., ... Lopez-Miranda, J. (2014). Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people. Age, 36(2), 507-517. https://doi.org/10.1007/s11357-013-9579-y

Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people. / Meza-Miranda, Eliana Romina; Camargo, Antonio; Rangel-Zuñiga, Oriol Alberto; Delgado-Lista, Javier; Garcia-Rios, Antonio; Perez-Martinez, Pablo; Tasset, Inmaculada; Tunez, Isaac; Tinahones, Francisco J.; Perez-Jimenez, Francisco; Lopez-Miranda, José.

In: Age, Vol. 36, No. 2, 2014, p. 507-517.

Research output: Contribution to journalArticle

Meza-Miranda, ER, Camargo, A, Rangel-Zuñiga, OA, Delgado-Lista, J, Garcia-Rios, A, Perez-Martinez, P, Tasset, I, Tunez, I, Tinahones, FJ, Perez-Jimenez, F & Lopez-Miranda, J 2014, 'Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people', Age, vol. 36, no. 2, pp. 507-517. https://doi.org/10.1007/s11357-013-9579-y
Meza-Miranda ER, Camargo A, Rangel-Zuñiga OA, Delgado-Lista J, Garcia-Rios A, Perez-Martinez P et al. Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people. Age. 2014;36(2):507-517. https://doi.org/10.1007/s11357-013-9579-y
Meza-Miranda, Eliana Romina ; Camargo, Antonio ; Rangel-Zuñiga, Oriol Alberto ; Delgado-Lista, Javier ; Garcia-Rios, Antonio ; Perez-Martinez, Pablo ; Tasset, Inmaculada ; Tunez, Isaac ; Tinahones, Francisco J. ; Perez-Jimenez, Francisco ; Lopez-Miranda, José. / Postprandial oxidative stress is modulated by dietary fat in adipose tissue from elderly people. In: Age. 2014 ; Vol. 36, No. 2. pp. 507-517.
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