Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q 10 in elderly men and women

Elena M. Yubero-Serrano, Nieves Delgado-Casado, Javier Delgado-Lista, Pablo Perez-Martinez, Inmaculada Tasset, Monica Santos-Gonzalez, Javier Caballero, Antonio Garcia-Rios, Carmen Marin, Francisco M. Gutierrez-Mariscal, Francisco Fuentes, Jose M. Villalba, Isaac Tunez, Francisco Perez-Jimenez, Jose Lopez-Miranda

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Postprandial oxidative stress is characterized by an increased susceptibility of the organism towards oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. We have investigated whether the quality of dietary fat alters postprandial cellular oxidative stress and whether the supplementation with coenzyme Q 10 (CoQ) lowers postprandial oxidative stress in an elderly population. In this randomized crossover study, 20 participants were assigned to receive three isocaloric diets for periods of 4 week each: (1) Mediterranean diet supplemented with CoQ (Med+CoQ diet), (2) Mediterranean diet (Med diet), and (3) saturated fatty acid-rich diet (SFA diet). After a 12-h fast, the volunteers consumed a breakfast with a fat composition similar to that consumed in each of the diets. CoQ, lipid peroxides (LPO), oxidized low-density lipoprotein (oxLDL), protein carbonyl (PC), total nitrite, nitrotyrosine plasma levels, catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities and ischemic reactive hyperaemia (IRH) were determined. Med diet produced a lower postprandial GPx activity and a lower decrease in total nitrite level compared to the SFA diet. Med and Med+CoQ diets induced a higher postprandial increase in IRH and a lower postprandial LPO, oxLDL, and nitrotyrosine plasma levels than the SFA diet. Moreover, the Med+CoQ diet produced a lower postprandial decrease in total nitrite and a greater decrease in PC levels compared to the other two diets and lower SOD, CAT, and GPx activities than the SFA diet. In conclusion, Med diet reduces postprandial oxidative stress by reducing processes of cellular oxidation and increases the action of the antioxidant system in elderly persons and the administration of CoQ further improves this redox balance.

Original languageEnglish (US)
Pages (from-to)579-590
Number of pages12
JournalAge
Volume33
Issue number4
DOIs
StatePublished - Dec 2011
Externally publishedYes

Fingerprint

Mediterranean Diet
Ubiquinone
Antioxidants
Diet
Oxidative Stress
Fatty Acids
Glutathione Peroxidase
Nitrites
Lipid Peroxides
Hyperemia
Superoxide Dismutase
Breakfast
Dietary Fats
Catalase
Cross-Over Studies
Oxidation-Reduction
Meals
Volunteers
Proteins
Fats

Keywords

  • Aging
  • Coenzyme Q10
  • Mediterranean diet
  • Oxidative stress
  • Postprandial phase

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Yubero-Serrano, E. M., Delgado-Casado, N., Delgado-Lista, J., Perez-Martinez, P., Tasset, I., Santos-Gonzalez, M., ... Lopez-Miranda, J. (2011). Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q 10 in elderly men and women. Age, 33(4), 579-590. https://doi.org/10.1007/s11357-010-9199-8

Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q 10 in elderly men and women. / Yubero-Serrano, Elena M.; Delgado-Casado, Nieves; Delgado-Lista, Javier; Perez-Martinez, Pablo; Tasset, Inmaculada; Santos-Gonzalez, Monica; Caballero, Javier; Garcia-Rios, Antonio; Marin, Carmen; Gutierrez-Mariscal, Francisco M.; Fuentes, Francisco; Villalba, Jose M.; Tunez, Isaac; Perez-Jimenez, Francisco; Lopez-Miranda, Jose.

In: Age, Vol. 33, No. 4, 12.2011, p. 579-590.

Research output: Contribution to journalArticle

Yubero-Serrano, EM, Delgado-Casado, N, Delgado-Lista, J, Perez-Martinez, P, Tasset, I, Santos-Gonzalez, M, Caballero, J, Garcia-Rios, A, Marin, C, Gutierrez-Mariscal, FM, Fuentes, F, Villalba, JM, Tunez, I, Perez-Jimenez, F & Lopez-Miranda, J 2011, 'Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q 10 in elderly men and women', Age, vol. 33, no. 4, pp. 579-590. https://doi.org/10.1007/s11357-010-9199-8
Yubero-Serrano EM, Delgado-Casado N, Delgado-Lista J, Perez-Martinez P, Tasset I, Santos-Gonzalez M et al. Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q 10 in elderly men and women. Age. 2011 Dec;33(4):579-590. https://doi.org/10.1007/s11357-010-9199-8
Yubero-Serrano, Elena M. ; Delgado-Casado, Nieves ; Delgado-Lista, Javier ; Perez-Martinez, Pablo ; Tasset, Inmaculada ; Santos-Gonzalez, Monica ; Caballero, Javier ; Garcia-Rios, Antonio ; Marin, Carmen ; Gutierrez-Mariscal, Francisco M. ; Fuentes, Francisco ; Villalba, Jose M. ; Tunez, Isaac ; Perez-Jimenez, Francisco ; Lopez-Miranda, Jose. / Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q 10 in elderly men and women. In: Age. 2011 ; Vol. 33, No. 4. pp. 579-590.
@article{e56a89df12084d539e1ebf2cb8e8d62c,
title = "Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q 10 in elderly men and women",
abstract = "Postprandial oxidative stress is characterized by an increased susceptibility of the organism towards oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. We have investigated whether the quality of dietary fat alters postprandial cellular oxidative stress and whether the supplementation with coenzyme Q 10 (CoQ) lowers postprandial oxidative stress in an elderly population. In this randomized crossover study, 20 participants were assigned to receive three isocaloric diets for periods of 4 week each: (1) Mediterranean diet supplemented with CoQ (Med+CoQ diet), (2) Mediterranean diet (Med diet), and (3) saturated fatty acid-rich diet (SFA diet). After a 12-h fast, the volunteers consumed a breakfast with a fat composition similar to that consumed in each of the diets. CoQ, lipid peroxides (LPO), oxidized low-density lipoprotein (oxLDL), protein carbonyl (PC), total nitrite, nitrotyrosine plasma levels, catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities and ischemic reactive hyperaemia (IRH) were determined. Med diet produced a lower postprandial GPx activity and a lower decrease in total nitrite level compared to the SFA diet. Med and Med+CoQ diets induced a higher postprandial increase in IRH and a lower postprandial LPO, oxLDL, and nitrotyrosine plasma levels than the SFA diet. Moreover, the Med+CoQ diet produced a lower postprandial decrease in total nitrite and a greater decrease in PC levels compared to the other two diets and lower SOD, CAT, and GPx activities than the SFA diet. In conclusion, Med diet reduces postprandial oxidative stress by reducing processes of cellular oxidation and increases the action of the antioxidant system in elderly persons and the administration of CoQ further improves this redox balance.",
keywords = "Aging, Coenzyme Q10, Mediterranean diet, Oxidative stress, Postprandial phase",
author = "Yubero-Serrano, {Elena M.} and Nieves Delgado-Casado and Javier Delgado-Lista and Pablo Perez-Martinez and Inmaculada Tasset and Monica Santos-Gonzalez and Javier Caballero and Antonio Garcia-Rios and Carmen Marin and Gutierrez-Mariscal, {Francisco M.} and Francisco Fuentes and Villalba, {Jose M.} and Isaac Tunez and Francisco Perez-Jimenez and Jose Lopez-Miranda",
year = "2011",
month = "12",
doi = "10.1007/s11357-010-9199-8",
language = "English (US)",
volume = "33",
pages = "579--590",
journal = "GeroScience",
issn = "2509-2715",
publisher = "Springer International Publishing AG",
number = "4",

}

TY - JOUR

T1 - Postprandial antioxidant effect of the Mediterranean diet supplemented with coenzyme Q 10 in elderly men and women

AU - Yubero-Serrano, Elena M.

AU - Delgado-Casado, Nieves

AU - Delgado-Lista, Javier

AU - Perez-Martinez, Pablo

AU - Tasset, Inmaculada

AU - Santos-Gonzalez, Monica

AU - Caballero, Javier

AU - Garcia-Rios, Antonio

AU - Marin, Carmen

AU - Gutierrez-Mariscal, Francisco M.

AU - Fuentes, Francisco

AU - Villalba, Jose M.

AU - Tunez, Isaac

AU - Perez-Jimenez, Francisco

AU - Lopez-Miranda, Jose

PY - 2011/12

Y1 - 2011/12

N2 - Postprandial oxidative stress is characterized by an increased susceptibility of the organism towards oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. We have investigated whether the quality of dietary fat alters postprandial cellular oxidative stress and whether the supplementation with coenzyme Q 10 (CoQ) lowers postprandial oxidative stress in an elderly population. In this randomized crossover study, 20 participants were assigned to receive three isocaloric diets for periods of 4 week each: (1) Mediterranean diet supplemented with CoQ (Med+CoQ diet), (2) Mediterranean diet (Med diet), and (3) saturated fatty acid-rich diet (SFA diet). After a 12-h fast, the volunteers consumed a breakfast with a fat composition similar to that consumed in each of the diets. CoQ, lipid peroxides (LPO), oxidized low-density lipoprotein (oxLDL), protein carbonyl (PC), total nitrite, nitrotyrosine plasma levels, catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities and ischemic reactive hyperaemia (IRH) were determined. Med diet produced a lower postprandial GPx activity and a lower decrease in total nitrite level compared to the SFA diet. Med and Med+CoQ diets induced a higher postprandial increase in IRH and a lower postprandial LPO, oxLDL, and nitrotyrosine plasma levels than the SFA diet. Moreover, the Med+CoQ diet produced a lower postprandial decrease in total nitrite and a greater decrease in PC levels compared to the other two diets and lower SOD, CAT, and GPx activities than the SFA diet. In conclusion, Med diet reduces postprandial oxidative stress by reducing processes of cellular oxidation and increases the action of the antioxidant system in elderly persons and the administration of CoQ further improves this redox balance.

AB - Postprandial oxidative stress is characterized by an increased susceptibility of the organism towards oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. We have investigated whether the quality of dietary fat alters postprandial cellular oxidative stress and whether the supplementation with coenzyme Q 10 (CoQ) lowers postprandial oxidative stress in an elderly population. In this randomized crossover study, 20 participants were assigned to receive three isocaloric diets for periods of 4 week each: (1) Mediterranean diet supplemented with CoQ (Med+CoQ diet), (2) Mediterranean diet (Med diet), and (3) saturated fatty acid-rich diet (SFA diet). After a 12-h fast, the volunteers consumed a breakfast with a fat composition similar to that consumed in each of the diets. CoQ, lipid peroxides (LPO), oxidized low-density lipoprotein (oxLDL), protein carbonyl (PC), total nitrite, nitrotyrosine plasma levels, catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities and ischemic reactive hyperaemia (IRH) were determined. Med diet produced a lower postprandial GPx activity and a lower decrease in total nitrite level compared to the SFA diet. Med and Med+CoQ diets induced a higher postprandial increase in IRH and a lower postprandial LPO, oxLDL, and nitrotyrosine plasma levels than the SFA diet. Moreover, the Med+CoQ diet produced a lower postprandial decrease in total nitrite and a greater decrease in PC levels compared to the other two diets and lower SOD, CAT, and GPx activities than the SFA diet. In conclusion, Med diet reduces postprandial oxidative stress by reducing processes of cellular oxidation and increases the action of the antioxidant system in elderly persons and the administration of CoQ further improves this redox balance.

KW - Aging

KW - Coenzyme Q10

KW - Mediterranean diet

KW - Oxidative stress

KW - Postprandial phase

UR - http://www.scopus.com/inward/record.url?scp=80755172236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80755172236&partnerID=8YFLogxK

U2 - 10.1007/s11357-010-9199-8

DO - 10.1007/s11357-010-9199-8

M3 - Article

VL - 33

SP - 579

EP - 590

JO - GeroScience

JF - GeroScience

SN - 2509-2715

IS - 4

ER -