Postoperative strategies after primary surgery for squamous cell carcinoma of the head and neck

Johannes A. Langendijk; Alfio Ferlito; Robert P. Takes; Juan P. Rodrigo; Carl Suárez; Primo Strojan; Missak Haigentz; Alessandra Rinaldo

doi:10.1016/j.oraloncology.2010.03.023

Postoperative strategies after primary surgery for squamous cell carcinoma of the head and neck

Johannes A. Langendijk, Alfio Ferlito, Robert P. Takes, Juan P. Rodrigo, Carl Suárez, Primo Strojan, Missak Haigentz, Alessandra Rinaldo

Medicine

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

This review discusses the role of adjuvant treatment after curative surgery for patients with head and neck squamous cell carcinoma (HNSCC). In general, patients with unfavourable prognostic factors have a high-risk of loco-regional recurrence and subsequent worse survival after surgery alone and are therefore considered proper candidates for adjuvant treatment by either postoperative radiotherapy alone or postoperative chemoradiation. Selection of the most optimal adjuvant treatment strategy should be based on the most important prognostic factors. In this review, the different treatment strategies will be discussed in general. More specifically, we will discuss the role of the interval between surgery and radiotherapy, the overall treatment time of radiation, the selection of target volumes for radiation and the value of adding concomitant chemotherapy to postoperative radiation.

Original language	English (US)
Pages (from-to)	577-585
Number of pages	9
Journal	Oral Oncology
Volume	46
Issue number	8
DOIs	https://doi.org/10.1016/j.oraloncology.2010.03.023
State	Published - Aug 2010

Keywords

Head and neck cancer
Postoperative chemoradiation
Postoperative radiotherapy
Squamous cell carcinoma

ASJC Scopus subject areas

Oral Surgery
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.oraloncology.2010.03.023

Cite this

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title = "Postoperative strategies after primary surgery for squamous cell carcinoma of the head and neck",

abstract = "This review discusses the role of adjuvant treatment after curative surgery for patients with head and neck squamous cell carcinoma (HNSCC). In general, patients with unfavourable prognostic factors have a high-risk of loco-regional recurrence and subsequent worse survival after surgery alone and are therefore considered proper candidates for adjuvant treatment by either postoperative radiotherapy alone or postoperative chemoradiation. Selection of the most optimal adjuvant treatment strategy should be based on the most important prognostic factors. In this review, the different treatment strategies will be discussed in general. More specifically, we will discuss the role of the interval between surgery and radiotherapy, the overall treatment time of radiation, the selection of target volumes for radiation and the value of adding concomitant chemotherapy to postoperative radiation.",

keywords = "Head and neck cancer, Postoperative chemoradiation, Postoperative radiotherapy, Squamous cell carcinoma",

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AU - Langendijk, Johannes A.

AU - Ferlito, Alfio

AU - Takes, Robert P.

AU - Rodrigo, Juan P.

AU - Suárez, Carl

AU - Strojan, Primo

AU - Haigentz, Missak

AU - Rinaldo, Alessandra

PY - 2010/8

Y1 - 2010/8

N2 - This review discusses the role of adjuvant treatment after curative surgery for patients with head and neck squamous cell carcinoma (HNSCC). In general, patients with unfavourable prognostic factors have a high-risk of loco-regional recurrence and subsequent worse survival after surgery alone and are therefore considered proper candidates for adjuvant treatment by either postoperative radiotherapy alone or postoperative chemoradiation. Selection of the most optimal adjuvant treatment strategy should be based on the most important prognostic factors. In this review, the different treatment strategies will be discussed in general. More specifically, we will discuss the role of the interval between surgery and radiotherapy, the overall treatment time of radiation, the selection of target volumes for radiation and the value of adding concomitant chemotherapy to postoperative radiation.

AB - This review discusses the role of adjuvant treatment after curative surgery for patients with head and neck squamous cell carcinoma (HNSCC). In general, patients with unfavourable prognostic factors have a high-risk of loco-regional recurrence and subsequent worse survival after surgery alone and are therefore considered proper candidates for adjuvant treatment by either postoperative radiotherapy alone or postoperative chemoradiation. Selection of the most optimal adjuvant treatment strategy should be based on the most important prognostic factors. In this review, the different treatment strategies will be discussed in general. More specifically, we will discuss the role of the interval between surgery and radiotherapy, the overall treatment time of radiation, the selection of target volumes for radiation and the value of adding concomitant chemotherapy to postoperative radiation.

KW - Head and neck cancer

KW - Postoperative chemoradiation

KW - Postoperative radiotherapy

KW - Squamous cell carcinoma

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JO - Oral Oncology

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Postoperative strategies after primary surgery for squamous cell carcinoma of the head and neck

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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