Post-transplant survival in idiopathic pulmonary fibrosis patients concurrently listed for single and double lung transplantation

Dhaval Chauhan, Ashwin B. Karanam, Aurelie Merlo, Pa Tom Bozzay, Mark J. Zucker, Harish Seethamraju, Nazly Shariati, Mark J. Russo

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Background Lung transplantation is a widely accepted treatment for patients with end-stage lung disease related to idiopathic pulmonary fibrosis (IPF). However, there are conflicting data on whether double lung transplant (DLT) or single lung transplant (SLT) is the superior therapy in these patients. The purpose of this study was to determine whether actuarial post-transplant graft survival among IPF patients concurrently listed for DLT and SLT is greater for recipients undergoing the former or the latter. Methods The United Network for Organ Sharing provided de-identified patient-level data. Analysis included lung transplant candidates with IPF listed between January 1, 2001 and December 31, 2009 (n = 3,411). The study population included 1,001 (29.3%) lung transplant recipients concurrently listed for DLT and SLT, all ≥18 years of age. The primary outcome measure was actuarial post-transplant graft survival, expressed in years. Results Among the study population, 433 (43.26%) recipients underwent SLT and 568 (56.74%) recipients underwent DLT. The analysis included 2,722.5 years at risk, with median graft survival of 5.31 years. On univariate (p = 0.317) and multivariate (p = 0.415) regression analyses, there was no difference in graft survival between DLT and SLT. Conclusions Among IPF recipients concurrently listed for DLT and SLT, there is no statistical difference in actuarial graft survival between recipients undergoing DLT vs SLT. This analysis suggests that increased use of SLT for IPF patients may increase the availability of organs to other candidates, and thus increase the net benefit of these organs, without measurably compromising outcomes.

Original languageEnglish (US)
Pages (from-to)657-660
Number of pages4
JournalJournal of Heart and Lung Transplantation
Volume35
Issue number5
DOIs
StatePublished - May 1 2016
Externally publishedYes

Keywords

  • idiopathic pulmonary fibrosis
  • lung transplantation
  • single vs. double lung transplant
  • survival analysis
  • UNOS/OPTN

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

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