Post-translational modifications in MeHg-induced neurotoxicity

Tao Ke, Filipe Marques Gonçalves, Cinara Ludvig Gonçalves, Alessandra Antunes dos Santos, João B.T. Rocha, Marcelo Farina, Anatoly Skalny, Aristidis Tsatsakis, Aaron B. Bowman, Michael Aschner

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Mercury (Hg) exposure remains a major public health concern due to its widespread distribution in the environment. Organic mercurials, such as MeHg, have been extensively investigated especially because of their congenital effects. In this context, studies on the molecular mechanism of MeHg-induced neurotoxicity are pivotal to the understanding of its toxic effects and the development of preventive measures. Post-translational modifications (PTMs) of proteins, such as phosphorylation, ubiquitination, and acetylation are essential for the proper function of proteins and play important roles in the regulation of cellular homeostasis. The rapid and transient nature of many PTMs allows efficient signal transduction in response to stress. This review summarizes the current knowledge of PTMs in MeHg-induced neurotoxicity, including the most commonly PTMs, as well as PTMs induced by oxidative stress and PTMs of antioxidant proteins. Though PTMs represent an important molecular mechanism for maintaining cellular homeostasis and are involved in the neurotoxic effects of MeHg, we are far from understanding the complete picture on their role, and further research is warranted to increase our knowledge of PTMs in MeHg-induced neurotoxicity.

Original languageEnglish (US)
Pages (from-to)2068-2081
Number of pages14
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1865
Issue number8
DOIs
StatePublished - Aug 1 2019

Keywords

  • Methylmercury
  • Neurotoxicity
  • Post-translational modification

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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  • Cite this

    Ke, T., Gonçalves, F. M., Gonçalves, C. L., dos Santos, A. A., Rocha, J. B. T., Farina, M., Skalny, A., Tsatsakis, A., Bowman, A. B., & Aschner, M. (2019). Post-translational modifications in MeHg-induced neurotoxicity. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1865(8), 2068-2081. https://doi.org/10.1016/j.bbadis.2018.10.024