Possible interaction between HLA-DRβ1 and thyroglobulin variants in Graves' disease

Susan E. Hodge, Yoshiyuki Ban, Lisa J. Strug, David A. Greenberg, Terry F. Davies, Erlinda S. Concepcion, Ronald Villanueva, Yaron Tomer

Research output: Contribution to journalArticle

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Abstract

Graves' disease (GD) is influenced by two major susceptibility loci, HLA-DR3 and thyroglobulin (Tg). Recently we have shown that specific HLA-DR and Tg gene sequences predispose to Graves' disease. Individuals carrying at least one arginine at position 74 of the DR/β1 chain (denoted the R- genotype) have a significantly increased risk of GD, as do individuals homozygous for the single nucleotide protein (SNP) in exon 33 of the Tg gene (denoted the CC genotype). Therefore, for the current study we hypothesized that these two genes may interact to influence the etiology of GD. To test this hypothesis, we analyzed the genotypes of 185 Caucasian patients with GD and 143 Caucasian controls for both genes. We tested for an interaction effect, that is, is one gene's effect on GD greater when the other gene is also present than when the other gene is absent? A logistic regression analysis yielded an estimate of 4.31 for the interaction term (p = 0.053). Our results may suggest an interaction between the R- and CC variants in conferring susceptibility to GD. These results, if confirmed, may imply that these two variants interact biologically to increase the odds of GD.

Original languageEnglish (US)
Pages (from-to)351-355
Number of pages5
JournalThyroid
Volume16
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

HLA-DR1 Antigen
Thyroglobulin
Graves Disease
Genes
Genotype
HLA-DR3 Antigen
HLA-DR Antigens
Arginine
Exons
Nucleotides
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Endocrinology

Cite this

Hodge, S. E., Ban, Y., Strug, L. J., Greenberg, D. A., Davies, T. F., Concepcion, E. S., ... Tomer, Y. (2006). Possible interaction between HLA-DRβ1 and thyroglobulin variants in Graves' disease. Thyroid, 16(4), 351-355. https://doi.org/10.1089/thy.2006.16.351

Possible interaction between HLA-DRβ1 and thyroglobulin variants in Graves' disease. / Hodge, Susan E.; Ban, Yoshiyuki; Strug, Lisa J.; Greenberg, David A.; Davies, Terry F.; Concepcion, Erlinda S.; Villanueva, Ronald; Tomer, Yaron.

In: Thyroid, Vol. 16, No. 4, 04.2006, p. 351-355.

Research output: Contribution to journalArticle

Hodge, SE, Ban, Y, Strug, LJ, Greenberg, DA, Davies, TF, Concepcion, ES, Villanueva, R & Tomer, Y 2006, 'Possible interaction between HLA-DRβ1 and thyroglobulin variants in Graves' disease', Thyroid, vol. 16, no. 4, pp. 351-355. https://doi.org/10.1089/thy.2006.16.351
Hodge SE, Ban Y, Strug LJ, Greenberg DA, Davies TF, Concepcion ES et al. Possible interaction between HLA-DRβ1 and thyroglobulin variants in Graves' disease. Thyroid. 2006 Apr;16(4):351-355. https://doi.org/10.1089/thy.2006.16.351
Hodge, Susan E. ; Ban, Yoshiyuki ; Strug, Lisa J. ; Greenberg, David A. ; Davies, Terry F. ; Concepcion, Erlinda S. ; Villanueva, Ronald ; Tomer, Yaron. / Possible interaction between HLA-DRβ1 and thyroglobulin variants in Graves' disease. In: Thyroid. 2006 ; Vol. 16, No. 4. pp. 351-355.
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