Positron emission tomography assessment of cerebral glucose metabolic rates in autism spectrum disorder and schizophrenia

Serge A. Mitelman, Marie Cecile Bralet, M. Mehmet Haznedar, Eric Hollander, Lina Shihabuddin, Erin A. Hazlett, Monte S. Buchsbaum

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Several models have been proposed to account for observed overlaps in clinical features and genetic predisposition between schizophrenia and autism spectrum disorder. This study assessed similarities and differences in topological patterns and vectors of glucose metabolism in both disorders in reference to these models. Co-registered 18fluorodeoxyglucose PET and MRI scans were obtained in 41 schizophrenia, 25 ASD, and 55 healthy control subjects. AFNI was used to map cortical and subcortical regions of interest. Metabolic rates were compared between three diagnostic groups using univariate and multivariate repeated-measures ANOVA. Compared to controls, metabolic rates in schizophrenia subjects were decreased in the frontal lobe, anterior cingulate, superior temporal gyrus, amygdala and medial thalamic nuclei; rates were increased in the occipital cortex, hippocampus, basal ganglia and lateral thalamic nuclei. In ASD subjects metabolic rates were decreased in the parietal lobe, frontal premotor and eye-fields areas, and amygdala; rates were increased in the posterior cingulate, occipital cortex, hippocampus and basal ganglia. In relation to controls, subjects with ASD and schizophrenia showed opposite changes in metabolic rates in the primary motor and somatosensory cortex, anterior cingulate and hypothalamus; similar changes were found in prefrontal and occipital cortices, inferior parietal lobule, amygdala, hippocampus, and basal ganglia. Schizophrenia and ASD appear to be associated with a similar pattern of metabolic abnormalities in the social brain. Divergent maladaptive trade-offs, as postulated by the diametrical hypothesis of their evolutionary relationship, may involve a more circumscribed set of anterior cingulate, motor and somatosensory regions and the specific cognitive functions they subserve.

Original languageEnglish (US)
Pages (from-to)1-15
Number of pages15
JournalBrain Imaging and Behavior
DOIs
StateAccepted/In press - Apr 19 2017

Fingerprint

Positron-Emission Tomography
Gyrus Cinguli
Schizophrenia
Occipital Lobe
Glucose
Amygdala
Basal Ganglia
Hippocampus
Parietal Lobe
Frontal Lobe
Lateral Thalamic Nuclei
Mediodorsal Thalamic Nucleus
Anterior Hypothalamus
Somatosensory Cortex
Motor Cortex
Temporal Lobe
Genetic Predisposition to Disease
Prefrontal Cortex
Cognition
Analysis of Variance

Keywords

  • Autism spectrum disorder
  • Diametrical diseases
  • Fluorodeoxyglucose
  • Positron emission tomography
  • Schizophrenia
  • Social brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience

Cite this

Mitelman, S. A., Bralet, M. C., Mehmet Haznedar, M., Hollander, E., Shihabuddin, L., Hazlett, E. A., & Buchsbaum, M. S. (Accepted/In press). Positron emission tomography assessment of cerebral glucose metabolic rates in autism spectrum disorder and schizophrenia. Brain Imaging and Behavior, 1-15. https://doi.org/10.1007/s11682-017-9721-z

Positron emission tomography assessment of cerebral glucose metabolic rates in autism spectrum disorder and schizophrenia. / Mitelman, Serge A.; Bralet, Marie Cecile; Mehmet Haznedar, M.; Hollander, Eric; Shihabuddin, Lina; Hazlett, Erin A.; Buchsbaum, Monte S.

In: Brain Imaging and Behavior, 19.04.2017, p. 1-15.

Research output: Contribution to journalArticle

Mitelman, Serge A. ; Bralet, Marie Cecile ; Mehmet Haznedar, M. ; Hollander, Eric ; Shihabuddin, Lina ; Hazlett, Erin A. ; Buchsbaum, Monte S. / Positron emission tomography assessment of cerebral glucose metabolic rates in autism spectrum disorder and schizophrenia. In: Brain Imaging and Behavior. 2017 ; pp. 1-15.
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