Positive association between HIV RNA and IL-6 in the genital tract of Rwandan women

Gregory T. Spear; M. Reza Zariffard; Hua Y. Chen; Joshua J. Anzinger; Kathryn Anastos; John Rusine; John Gatabazi; Audrey L. French; Mardge Cohen; Alan L. Landay

doi:10.1089/aid.2008.0004

Positive association between HIV RNA and IL-6 in the genital tract of Rwandan women

Gregory T. Spear, M. Reza Zariffard, Hua Y. Chen, Joshua J. Anzinger, Kathryn Anastos, John Rusine, John Gatabazi, Audrey L. French, Mardge Cohen, Alan L. Landay

Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Infections and inflammation in the genital tract can influence HIV expression or HIV susceptibility. The goal of this study was to determine if significant relationships exist between cytokines and HIV in genital tract secretions from 57 HIV-seropositive Rwandan women. Genital tract secretions were obtained by cervicovaginal lavage (CVL). Ten different cytokines in CVL were measured by multiplex cytometric bead arrays. HIV RNA in CVL and plasma were measured by quantitative PCR. In univariate analysis, genital tract HIV RNA was significantly associated with plasma HIV RNA and several of the cytokines, while in multivariate analysis, genital tract HIV RNA was significantly associated only with plasma HIV RNA and IL-6. This association of IL-6 with HIV RNA levels suggests that IL-6 is an indicator for conditions that induce HIV expression and that IL-6 may contribute to induction of HIV expression in the genital tract.

Original language	English (US)
Pages (from-to)	973-976
Number of pages	4
Journal	AIDS Research and Human Retroviruses
Volume	24
Issue number	7
DOIs	https://doi.org/10.1089/aid.2008.0004
State	Published - Jul 1 2008

ASJC Scopus subject areas

Immunology
Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1089/aid.2008.0004

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title = "Positive association between HIV RNA and IL-6 in the genital tract of Rwandan women",

abstract = "Infections and inflammation in the genital tract can influence HIV expression or HIV susceptibility. The goal of this study was to determine if significant relationships exist between cytokines and HIV in genital tract secretions from 57 HIV-seropositive Rwandan women. Genital tract secretions were obtained by cervicovaginal lavage (CVL). Ten different cytokines in CVL were measured by multiplex cytometric bead arrays. HIV RNA in CVL and plasma were measured by quantitative PCR. In univariate analysis, genital tract HIV RNA was significantly associated with plasma HIV RNA and several of the cytokines, while in multivariate analysis, genital tract HIV RNA was significantly associated only with plasma HIV RNA and IL-6. This association of IL-6 with HIV RNA levels suggests that IL-6 is an indicator for conditions that induce HIV expression and that IL-6 may contribute to induction of HIV expression in the genital tract.",

author = "Spear, {Gregory T.} and Zariffard, {M. Reza} and Chen, {Hua Y.} and Anzinger, {Joshua J.} and Kathryn Anastos and John Rusine and John Gatabazi and French, {Audrey L.} and Mardge Cohen and Landay, {Alan L.}",

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AU - Spear, Gregory T.

AU - Zariffard, M. Reza

AU - Chen, Hua Y.

AU - Anzinger, Joshua J.

AU - Anastos, Kathryn

AU - Rusine, John

AU - Gatabazi, John

AU - French, Audrey L.

AU - Cohen, Mardge

AU - Landay, Alan L.

PY - 2008/7/1

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N2 - Infections and inflammation in the genital tract can influence HIV expression or HIV susceptibility. The goal of this study was to determine if significant relationships exist between cytokines and HIV in genital tract secretions from 57 HIV-seropositive Rwandan women. Genital tract secretions were obtained by cervicovaginal lavage (CVL). Ten different cytokines in CVL were measured by multiplex cytometric bead arrays. HIV RNA in CVL and plasma were measured by quantitative PCR. In univariate analysis, genital tract HIV RNA was significantly associated with plasma HIV RNA and several of the cytokines, while in multivariate analysis, genital tract HIV RNA was significantly associated only with plasma HIV RNA and IL-6. This association of IL-6 with HIV RNA levels suggests that IL-6 is an indicator for conditions that induce HIV expression and that IL-6 may contribute to induction of HIV expression in the genital tract.

AB - Infections and inflammation in the genital tract can influence HIV expression or HIV susceptibility. The goal of this study was to determine if significant relationships exist between cytokines and HIV in genital tract secretions from 57 HIV-seropositive Rwandan women. Genital tract secretions were obtained by cervicovaginal lavage (CVL). Ten different cytokines in CVL were measured by multiplex cytometric bead arrays. HIV RNA in CVL and plasma were measured by quantitative PCR. In univariate analysis, genital tract HIV RNA was significantly associated with plasma HIV RNA and several of the cytokines, while in multivariate analysis, genital tract HIV RNA was significantly associated only with plasma HIV RNA and IL-6. This association of IL-6 with HIV RNA levels suggests that IL-6 is an indicator for conditions that induce HIV expression and that IL-6 may contribute to induction of HIV expression in the genital tract.

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Positive association between HIV RNA and IL-6 in the genital tract of Rwandan women

Abstract

ASJC Scopus subject areas

UN SDGs

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