TY - JOUR
T1 - Poor Gait Performance and Prediction of Dementia
T2 - Results From a Meta-Analysis
AU - Beauchet, Olivier
AU - Annweiler, Cédric
AU - Callisaya, Michele L.
AU - De Cock, Anne Marie
AU - Helbostad, Jorunn L.
AU - Kressig, Reto W.
AU - Srikanth, Velandai
AU - Steinmetz, Jean Paul
AU - Blumen, Helena M.
AU - Verghese, Joe
AU - Allali, Gilles
N1 - Funding Information:
The statistical analysis was conducted by Olivier Beauchet, MD, PhD. G Allali is supported by a grant from the Geneva University Hospitals and the Resnick Gerontology Center, Albert Einstein College of Medicine, Yeshiva University.
Publisher Copyright:
© 2016 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Background: Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia. Methods: An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms "Gait" OR "Gait Disorders, Neurologic" OR "Gait Apraxia" OR "Gait Ataxia" AND "Dementia" OR "Frontotemporal Dementia" OR "Dementia, Multi-Infarct" OR "Dementia, Vascular" OR "Alzheimer Disease" OR "Lewy Body Disease" OR "Frontotemporal Dementia With Motor Neuron Disease" (Supplementary Concept). Poor gait performance was defined by standardized tests of walking, and dementia was diagnosed according to international consensus criteria. Four etiologies of dementia were identified: any dementia, Alzheimer disease (AD), vascular dementia (VaD), and non-AD (ie, pooling VaD, mixed dementias, and other dementias). Fixed effects meta-analyses were performed on the estimates in order to generate summary values. Results: Of the 796 identified abstracts, 12 (1.5%) were included in this systematic review and meta-analysis. Poor gait performance predicted dementia [pooled hazard ratio (HR) combined with relative risk and odds ratio = 1.53 with P < .001 for any dementia, pooled HR = 1.79 with P < .001 for VaD, HR = 1.89 with P value < .001 for non-AD]. Findings were weaker for predicting AD (HR = 1.03 with P value = .004). Conclusions: This meta-analysis provides evidence that poor gait performance predicts dementia. This association depends on the type of dementia; poor gait performance is a stronger predictor of non-AD dementias than AD.
AB - Background: Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia. Methods: An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms "Gait" OR "Gait Disorders, Neurologic" OR "Gait Apraxia" OR "Gait Ataxia" AND "Dementia" OR "Frontotemporal Dementia" OR "Dementia, Multi-Infarct" OR "Dementia, Vascular" OR "Alzheimer Disease" OR "Lewy Body Disease" OR "Frontotemporal Dementia With Motor Neuron Disease" (Supplementary Concept). Poor gait performance was defined by standardized tests of walking, and dementia was diagnosed according to international consensus criteria. Four etiologies of dementia were identified: any dementia, Alzheimer disease (AD), vascular dementia (VaD), and non-AD (ie, pooling VaD, mixed dementias, and other dementias). Fixed effects meta-analyses were performed on the estimates in order to generate summary values. Results: Of the 796 identified abstracts, 12 (1.5%) were included in this systematic review and meta-analysis. Poor gait performance predicted dementia [pooled hazard ratio (HR) combined with relative risk and odds ratio = 1.53 with P < .001 for any dementia, pooled HR = 1.79 with P < .001 for VaD, HR = 1.89 with P value < .001 for non-AD]. Findings were weaker for predicting AD (HR = 1.03 with P value = .004). Conclusions: This meta-analysis provides evidence that poor gait performance predicts dementia. This association depends on the type of dementia; poor gait performance is a stronger predictor of non-AD dementias than AD.
KW - Dementia
KW - Epidemiology
KW - Gait disorders/ataxia
KW - Motor control
UR - http://www.scopus.com/inward/record.url?scp=84957096800&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957096800&partnerID=8YFLogxK
U2 - 10.1016/j.jamda.2015.12.092
DO - 10.1016/j.jamda.2015.12.092
M3 - Review article
C2 - 26852960
AN - SCOPUS:84957096800
SN - 1525-8610
VL - 17
SP - 482
EP - 490
JO - Journal of the American Medical Directors Association
JF - Journal of the American Medical Directors Association
IS - 6
ER -
