Poor Gait Performance and Prediction of Dementia

Results From a Meta-Analysis

Olivier Beauchet, Cédric Annweiler, Michele L. Callisaya, Anne Marie De Cock, Jorunn L. Helbostad, Reto W. Kressig, Velandai Srikanth, Jean Paul Steinmetz, Helena M. Blumen, Joe Verghese, Gilles Allali

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background: Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia. Methods: An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms "Gait" OR "Gait Disorders, Neurologic" OR "Gait Apraxia" OR "Gait Ataxia" AND "Dementia" OR "Frontotemporal Dementia" OR "Dementia, Multi-Infarct" OR "Dementia, Vascular" OR "Alzheimer Disease" OR "Lewy Body Disease" OR "Frontotemporal Dementia With Motor Neuron Disease" (Supplementary Concept). Poor gait performance was defined by standardized tests of walking, and dementia was diagnosed according to international consensus criteria. Four etiologies of dementia were identified: any dementia, Alzheimer disease (AD), vascular dementia (VaD), and non-AD (ie, pooling VaD, mixed dementias, and other dementias). Fixed effects meta-analyses were performed on the estimates in order to generate summary values. Results: Of the 796 identified abstracts, 12 (1.5%) were included in this systematic review and meta-analysis. Poor gait performance predicted dementia [pooled hazard ratio (HR) combined with relative risk and odds ratio = 1.53 with P <.001 for any dementia, pooled HR = 1.79 with P <.001 for VaD, HR = 1.89 with P value <.001 for non-AD]. Findings were weaker for predicting AD (HR = 1.03 with P value = .004). Conclusions: This meta-analysis provides evidence that poor gait performance predicts dementia. This association depends on the type of dementia; poor gait performance is a stronger predictor of non-AD dementias than AD.

Original languageEnglish (US)
JournalJournal of the American Medical Directors Association
DOIs
StateAccepted/In press - 2016

Fingerprint

Gait
Dementia
Meta-Analysis
Vascular Dementia
Gait Apraxia
Alzheimer Disease
Odds Ratio
Gait Ataxia
Multi-Infarct Dementia
Neurologic Gait Disorders
Medical Subject Headings
Lewy Body Disease
Frontotemporal Dementia
Vascular Diseases
Walking
Consensus

Keywords

  • Dementia
  • Epidemiology
  • Gait disorders/ataxia
  • Motor control

ASJC Scopus subject areas

  • Medicine(all)
  • Nursing(all)
  • Health Policy

Cite this

Beauchet, O., Annweiler, C., Callisaya, M. L., De Cock, A. M., Helbostad, J. L., Kressig, R. W., ... Allali, G. (Accepted/In press). Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis. Journal of the American Medical Directors Association. https://doi.org/10.1016/j.jamda.2015.12.092

Poor Gait Performance and Prediction of Dementia : Results From a Meta-Analysis. / Beauchet, Olivier; Annweiler, Cédric; Callisaya, Michele L.; De Cock, Anne Marie; Helbostad, Jorunn L.; Kressig, Reto W.; Srikanth, Velandai; Steinmetz, Jean Paul; Blumen, Helena M.; Verghese, Joe; Allali, Gilles.

In: Journal of the American Medical Directors Association, 2016.

Research output: Contribution to journalArticle

Beauchet, O, Annweiler, C, Callisaya, ML, De Cock, AM, Helbostad, JL, Kressig, RW, Srikanth, V, Steinmetz, JP, Blumen, HM, Verghese, J & Allali, G 2016, 'Poor Gait Performance and Prediction of Dementia: Results From a Meta-Analysis', Journal of the American Medical Directors Association. https://doi.org/10.1016/j.jamda.2015.12.092
Beauchet, Olivier ; Annweiler, Cédric ; Callisaya, Michele L. ; De Cock, Anne Marie ; Helbostad, Jorunn L. ; Kressig, Reto W. ; Srikanth, Velandai ; Steinmetz, Jean Paul ; Blumen, Helena M. ; Verghese, Joe ; Allali, Gilles. / Poor Gait Performance and Prediction of Dementia : Results From a Meta-Analysis. In: Journal of the American Medical Directors Association. 2016.
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abstract = "Background: Poor gait performance predicts risk of developing dementia. No structured critical evaluation has been conducted to study this association yet. The aim of this meta-analysis was to systematically examine the association of poor gait performance with incidence of dementia. Methods: An English and French Medline search was conducted in June 2015, with no limit of date, using the medical subject headings terms {"}Gait{"} OR {"}Gait Disorders, Neurologic{"} OR {"}Gait Apraxia{"} OR {"}Gait Ataxia{"} AND {"}Dementia{"} OR {"}Frontotemporal Dementia{"} OR {"}Dementia, Multi-Infarct{"} OR {"}Dementia, Vascular{"} OR {"}Alzheimer Disease{"} OR {"}Lewy Body Disease{"} OR {"}Frontotemporal Dementia With Motor Neuron Disease{"} (Supplementary Concept). Poor gait performance was defined by standardized tests of walking, and dementia was diagnosed according to international consensus criteria. Four etiologies of dementia were identified: any dementia, Alzheimer disease (AD), vascular dementia (VaD), and non-AD (ie, pooling VaD, mixed dementias, and other dementias). Fixed effects meta-analyses were performed on the estimates in order to generate summary values. Results: Of the 796 identified abstracts, 12 (1.5{\%}) were included in this systematic review and meta-analysis. Poor gait performance predicted dementia [pooled hazard ratio (HR) combined with relative risk and odds ratio = 1.53 with P <.001 for any dementia, pooled HR = 1.79 with P <.001 for VaD, HR = 1.89 with P value <.001 for non-AD]. Findings were weaker for predicting AD (HR = 1.03 with P value = .004). Conclusions: This meta-analysis provides evidence that poor gait performance predicts dementia. This association depends on the type of dementia; poor gait performance is a stronger predictor of non-AD dementias than AD.",
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AU - De Cock, Anne Marie

AU - Helbostad, Jorunn L.

AU - Kressig, Reto W.

AU - Srikanth, Velandai

AU - Steinmetz, Jean Paul

AU - Blumen, Helena M.

AU - Verghese, Joe

AU - Allali, Gilles

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KW - Epidemiology

KW - Gait disorders/ataxia

KW - Motor control

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