TY - JOUR
T1 - Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk
AU - Van Den Brandt, Piet A.
AU - Spiegelman, Donna
AU - Yaun, Shiaw Shyuan
AU - Adami, Hans Olov
AU - Beeson, Lawrence
AU - Folsom, Aaron R.
AU - Fraser, Gary
AU - Goldbohm, R. Alexandra
AU - Graham, Saxon
AU - Kushi, Larry
AU - Marshall, James R.
AU - Miller, Anthony B.
AU - Rohan, Tom
AU - Smith-Warner, Stephanie A.
AU - Speizer, Frank E.
AU - Willett, Walter C.
AU - Wolk, Alicja
AU - Hunter, David J.
PY - 2000/9/15
Y1 - 2000/9/15
N2 - The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases. In multivariate analyses controlling for reproductive, dietary, and other risk factors, the pooled relative risk (RR) of breast cancer per height increment of 5 cm was 1.02 (95% confidence interval (Cl): 0.96, 1.10) in premenopausal women and 1.07 (95% Cl: 1.03, 1.12) in postmenopausal women. Body mass index (BMI) showed significant inverse and positive associations with breast cancer among pre- and postmenopausal women, respectively; these associations were nonlinear. Compared with premenopausal women with a BMI of less than 21 kg/m2, women with a BMI exceeding 31 kg/m2 had an RR of 0.54 (95% Cl: 0.34, 0.85). In postmenopausal women, the RRs did not increase further when BMI exceeded 28 kg/m2; the RR for these women was 1.26 (95% Cl: 1.09, 1.46). The authors found little evidence for interaction with other breast cancer risk factors. Their data indicate that height is an independent risk factor for postmenopausal breast cancer; in premenopausal women, this relation is less clear. The association between BMI and breast cancer varies by menopausal status. Weight control may reduce the risk among postmenopausal women.
AB - The association between anthropometric indices and the risk of breast cancer was analyzed using pooled data from seven prospective cohort studies. Together, these cohorts comprise 337,819 women and 4,385 incident invasive breast cancer cases. In multivariate analyses controlling for reproductive, dietary, and other risk factors, the pooled relative risk (RR) of breast cancer per height increment of 5 cm was 1.02 (95% confidence interval (Cl): 0.96, 1.10) in premenopausal women and 1.07 (95% Cl: 1.03, 1.12) in postmenopausal women. Body mass index (BMI) showed significant inverse and positive associations with breast cancer among pre- and postmenopausal women, respectively; these associations were nonlinear. Compared with premenopausal women with a BMI of less than 21 kg/m2, women with a BMI exceeding 31 kg/m2 had an RR of 0.54 (95% Cl: 0.34, 0.85). In postmenopausal women, the RRs did not increase further when BMI exceeded 28 kg/m2; the RR for these women was 1.26 (95% Cl: 1.09, 1.46). The authors found little evidence for interaction with other breast cancer risk factors. Their data indicate that height is an independent risk factor for postmenopausal breast cancer; in premenopausal women, this relation is less clear. The association between BMI and breast cancer varies by menopausal status. Weight control may reduce the risk among postmenopausal women.
KW - Body height
KW - Body weight
KW - Breast neoplasms
KW - Prospective studies
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U2 - 10.1093/aje/152.6.514
DO - 10.1093/aje/152.6.514
M3 - Article
C2 - 10997541
AN - SCOPUS:0034666098
SN - 0002-9262
VL - 152
SP - 514
EP - 527
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 6
ER -
