Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: A case-control study

Delia C. Tang, Ron Prauner, Wenli Liu, Kye Hyun Kim, Robert P. Hirsch, M. Catherine Driscoll, Griffin P. Rodgers

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Stroke is one of the most devastating complications of patients with sickle cell disease (SCD). Currently, there are no known molecular or genetic markers that can be used to assess the risk of stroke in this population. We have previously shown that relative hypertension may be one risk factor for stroke in SCD. In a case-control study, we investigated the association between GT-repeat polymorphism within the angiotensinogen (AGT) gene and the risk of stroke in pediatric patients with SCD, After informed consent was obtained, 63 patients (21 stroke subjects and 42 nonstroke control subjects matched according to age and sex) with SCD followed at local pediatric hematology clinics were genotyped to test the association of specific GT-repeat alleles of the AGT gene and occurrence of stroke. There were statistical differences in the distribution of the genotypes among stroke and nonstroke SCD patients (χ2 = 10.82, df = 11, P < 0.05). We also found GT-repeat alleles A3 and/or A4 of the AGT gene conferred a four-fold increase in the risk of stroke (odds ratio [OR] = 4, P < 0.05). The attributable odds ratio for allele A3 and A4 is 2.24 and 4.33, respectively (P < 0,005). Our results suggest that GT-repeat within the AGT gene may be associated with risk of stroke in pediatric SCD. The relative risk of stroke in the presence of alleles A3 and/or A4 is fourfold greater than in the absence of these alleles. If these data are substantiated in a larger cohort of patients, our results indicate that the determination of GT-repeat of AGT gene may be a useful genetic marker to assess the risk for stroke of patients with SCD. 2001 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)164-169
Number of pages6
JournalAmerican Journal of Hematology
Volume68
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Angiotensinogen
Sickle Cell Anemia
Case-Control Studies
Stroke
Pediatrics
Genes
Alleles
Genetic Markers
Odds Ratio
Hematology
Informed Consent
Molecular Biology
Genotype

Keywords

  • Angiotensinogen
  • GT-repeat
  • Sickle cell diseases
  • Stroke

ASJC Scopus subject areas

  • Hematology

Cite this

Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease : A case-control study. / Tang, Delia C.; Prauner, Ron; Liu, Wenli; Kim, Kye Hyun; Hirsch, Robert P.; Catherine Driscoll, M.; Rodgers, Griffin P.

In: American Journal of Hematology, Vol. 68, No. 3, 2001, p. 164-169.

Research output: Contribution to journalArticle

Tang, Delia C. ; Prauner, Ron ; Liu, Wenli ; Kim, Kye Hyun ; Hirsch, Robert P. ; Catherine Driscoll, M. ; Rodgers, Griffin P. / Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease : A case-control study. In: American Journal of Hematology. 2001 ; Vol. 68, No. 3. pp. 164-169.
@article{a6070691065743c1bebe84f84dcb8255,
title = "Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease: A case-control study",
abstract = "Stroke is one of the most devastating complications of patients with sickle cell disease (SCD). Currently, there are no known molecular or genetic markers that can be used to assess the risk of stroke in this population. We have previously shown that relative hypertension may be one risk factor for stroke in SCD. In a case-control study, we investigated the association between GT-repeat polymorphism within the angiotensinogen (AGT) gene and the risk of stroke in pediatric patients with SCD, After informed consent was obtained, 63 patients (21 stroke subjects and 42 nonstroke control subjects matched according to age and sex) with SCD followed at local pediatric hematology clinics were genotyped to test the association of specific GT-repeat alleles of the AGT gene and occurrence of stroke. There were statistical differences in the distribution of the genotypes among stroke and nonstroke SCD patients (χ2 = 10.82, df = 11, P < 0.05). We also found GT-repeat alleles A3 and/or A4 of the AGT gene conferred a four-fold increase in the risk of stroke (odds ratio [OR] = 4, P < 0.05). The attributable odds ratio for allele A3 and A4 is 2.24 and 4.33, respectively (P < 0,005). Our results suggest that GT-repeat within the AGT gene may be associated with risk of stroke in pediatric SCD. The relative risk of stroke in the presence of alleles A3 and/or A4 is fourfold greater than in the absence of these alleles. If these data are substantiated in a larger cohort of patients, our results indicate that the determination of GT-repeat of AGT gene may be a useful genetic marker to assess the risk for stroke of patients with SCD. 2001 Wiley-Liss, Inc.",
keywords = "Angiotensinogen, GT-repeat, Sickle cell diseases, Stroke",
author = "Tang, {Delia C.} and Ron Prauner and Wenli Liu and Kim, {Kye Hyun} and Hirsch, {Robert P.} and {Catherine Driscoll}, M. and Rodgers, {Griffin P.}",
year = "2001",
doi = "10.1002/ajh.1173",
language = "English (US)",
volume = "68",
pages = "164--169",
journal = "American Journal of Hematology",
issn = "0361-8609",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Polymorphisms within the angiotensinogen gene (GT-repeat) and the risk of stroke in pediatric patients with sickle cell disease

T2 - A case-control study

AU - Tang, Delia C.

AU - Prauner, Ron

AU - Liu, Wenli

AU - Kim, Kye Hyun

AU - Hirsch, Robert P.

AU - Catherine Driscoll, M.

AU - Rodgers, Griffin P.

PY - 2001

Y1 - 2001

N2 - Stroke is one of the most devastating complications of patients with sickle cell disease (SCD). Currently, there are no known molecular or genetic markers that can be used to assess the risk of stroke in this population. We have previously shown that relative hypertension may be one risk factor for stroke in SCD. In a case-control study, we investigated the association between GT-repeat polymorphism within the angiotensinogen (AGT) gene and the risk of stroke in pediatric patients with SCD, After informed consent was obtained, 63 patients (21 stroke subjects and 42 nonstroke control subjects matched according to age and sex) with SCD followed at local pediatric hematology clinics were genotyped to test the association of specific GT-repeat alleles of the AGT gene and occurrence of stroke. There were statistical differences in the distribution of the genotypes among stroke and nonstroke SCD patients (χ2 = 10.82, df = 11, P < 0.05). We also found GT-repeat alleles A3 and/or A4 of the AGT gene conferred a four-fold increase in the risk of stroke (odds ratio [OR] = 4, P < 0.05). The attributable odds ratio for allele A3 and A4 is 2.24 and 4.33, respectively (P < 0,005). Our results suggest that GT-repeat within the AGT gene may be associated with risk of stroke in pediatric SCD. The relative risk of stroke in the presence of alleles A3 and/or A4 is fourfold greater than in the absence of these alleles. If these data are substantiated in a larger cohort of patients, our results indicate that the determination of GT-repeat of AGT gene may be a useful genetic marker to assess the risk for stroke of patients with SCD. 2001 Wiley-Liss, Inc.

AB - Stroke is one of the most devastating complications of patients with sickle cell disease (SCD). Currently, there are no known molecular or genetic markers that can be used to assess the risk of stroke in this population. We have previously shown that relative hypertension may be one risk factor for stroke in SCD. In a case-control study, we investigated the association between GT-repeat polymorphism within the angiotensinogen (AGT) gene and the risk of stroke in pediatric patients with SCD, After informed consent was obtained, 63 patients (21 stroke subjects and 42 nonstroke control subjects matched according to age and sex) with SCD followed at local pediatric hematology clinics were genotyped to test the association of specific GT-repeat alleles of the AGT gene and occurrence of stroke. There were statistical differences in the distribution of the genotypes among stroke and nonstroke SCD patients (χ2 = 10.82, df = 11, P < 0.05). We also found GT-repeat alleles A3 and/or A4 of the AGT gene conferred a four-fold increase in the risk of stroke (odds ratio [OR] = 4, P < 0.05). The attributable odds ratio for allele A3 and A4 is 2.24 and 4.33, respectively (P < 0,005). Our results suggest that GT-repeat within the AGT gene may be associated with risk of stroke in pediatric SCD. The relative risk of stroke in the presence of alleles A3 and/or A4 is fourfold greater than in the absence of these alleles. If these data are substantiated in a larger cohort of patients, our results indicate that the determination of GT-repeat of AGT gene may be a useful genetic marker to assess the risk for stroke of patients with SCD. 2001 Wiley-Liss, Inc.

KW - Angiotensinogen

KW - GT-repeat

KW - Sickle cell diseases

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=0034776219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034776219&partnerID=8YFLogxK

U2 - 10.1002/ajh.1173

DO - 10.1002/ajh.1173

M3 - Article

C2 - 11754397

AN - SCOPUS:0034776219

VL - 68

SP - 164

EP - 169

JO - American Journal of Hematology

JF - American Journal of Hematology

SN - 0361-8609

IS - 3

ER -