Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk

Virginia Kaklamani, Nengjun Yi, Kui Zhang, Maureen Sadim, Kenneth Offit, Carole Oddoux, Harry Ostrer, Christos Mantzoros, Boris Pasche

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Studies have linked prostate cancer risk with insulin resistance and obesity. Circulating levels of adiponectin, a protein involved in insulin resistance and obesity, have been associated with prostate cancer risk. We studied the association of prostate cancer risk with haplotype tagging single nucleotide polymorphisms (SNPs) of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) chosen based on their functional relevance or association with other types of cancer. DNA samples from 465 cases and 441 healthy volunteers from New York City were genotyped for ADIPOQ rs266729, rs822395, rs822396, rs1501299, and rs2241766 SNPs and ADIPOR1 rs12733285, rs1342387, rs7539542, rs2232853, and rs10920531 SNPs. We performed both single- and multiple-SNP analyses. We found that rs12733285, rs7539452, rs266729, rs822395, rs822396, and rs1501299 were significantly associated with prostate cancer risk. Haplotype analysis confirmed these results and identified 5 ADIPOQ 4-SNP haplotypes and 1 ADIPOR1 2-SNP haplotype tightly associated with prostate cancer risk. Importantly, 2 ADIPOQ SNPs, rs266729 and rs1501299, have been previously associated with colon and breast cancer risk, respectively, in the same direction as in this study. These findings suggest that variants of the adiponectin pathway may be associated with susceptibility to various forms of common cancers and warrant validation studies.

Original languageEnglish (US)
Pages (from-to)1234-1243
Number of pages10
JournalMetabolism: Clinical and Experimental
Volume60
Issue number9
DOIs
StatePublished - Sep 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Fingerprint Dive into the research topics of 'Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk'. Together they form a unique fingerprint.

  • Cite this

    Kaklamani, V., Yi, N., Zhang, K., Sadim, M., Offit, K., Oddoux, C., Ostrer, H., Mantzoros, C., & Pasche, B. (2011). Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk. Metabolism: Clinical and Experimental, 60(9), 1234-1243. https://doi.org/10.1016/j.metabol.2011.01.005