Polymorphisms in integrin genes and lymphoma risk

Min Shen, Tongzhang Zheng, Qing Lan, Yawei Zhang, H. Dean Hosgood, Shelia H. Zahm, Theodore R. Holford, Brian Leaderer, Meredith Yeager, Jeff Yuenger, Stephen Chanock, Nathaniel Rothman

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Immune deficiency is one of the best characterized and strongest known risk factors for non-Hodgkin lymphoma (NHL). We studied the association between single nucleotide polymorphisms (SNPs) in integrin genes that are important components in human innate immunity and the risk of NHL in a population-based case-control study of women in Connecticut, USA. A total of 373 tag SNPs in 33 gene regions were included in the analysis of 448 cases and 525 controls. The ADAM19 rs11466782 SNP was associated with an increased risk of lymphoma (OR, 1.73; 95% CI, 1.28-2.35; Padditive=0.0004), and the ICAM3 rs2304240 (OR, 0.67; 95% CI, 0.52-0.86; Padditive=0.002) and the PTGDR rs708486 SNPs (OR, 0.75; 95% CI, 0.63-0.90; Padditive=0.002) were associated with reduced risk of lymphoma. Two gene regions (ADAM19 (P=0.009) and ICAM3 (P=0.009)) displayed global associations with lymphoma risk at the P<0.01 level. While our results suggest that genetic polymorphisms in integrin genes may play a role in the genesis of lymphoma in women, they should be viewed as exploratory until they are replicated in additional populations.

Original languageEnglish (US)
Pages (from-to)968-970
Number of pages3
JournalLeukemia Research
Volume35
Issue number7
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

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Keywords

  • Innate immunity
  • Integrin
  • Lymphoma
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Shen, M., Zheng, T., Lan, Q., Zhang, Y., Hosgood, H. D., Zahm, S. H., Holford, T. R., Leaderer, B., Yeager, M., Yuenger, J., Chanock, S., & Rothman, N. (2011). Polymorphisms in integrin genes and lymphoma risk. Leukemia Research, 35(7), 968-970. https://doi.org/10.1016/j.leukres.2010.12.012