Point mutation of K-ras gene in pancreatic carcinoma

Y. T. Huang, Y. M. Yang, Qiang Liu

Research output: Contribution to journalArticle

Abstract

Direct sequencing using Taq enzyme was established for determination of point mutation of K-ras gene at codon 12 in 9 wax samples of pancreatic carcinoma (PC) and 1 of islet cell tumor. Point mutation occurred in 5 of 9 samples of PC and manifested two types of mutation, CCA-->CGA in 4 and CCA-->CAA in 1. The changes of amino acid included changes of glycine to alanine and glycine to valine. The causes of mutation frequency and the content differed from that of foreign reports were analysed in addition to the significance of determining point mutation of K-ras gene at codon 12.

Original languageEnglish (US)
Pages (from-to)77-79, 125
JournalZhonghua yi xue za zhi
Volume74
Issue number2
StatePublished - Feb 1994
Externally publishedYes

Fingerprint

ras Genes
Point Mutation
Codon
Glycine
Islet Cell Adenoma
Waxes
Valine
Mutation Rate
Alanine
Amino Acids
Mutation
Enzymes
Pancreatic Carcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Huang, Y. T., Yang, Y. M., & Liu, Q. (1994). Point mutation of K-ras gene in pancreatic carcinoma. Zhonghua yi xue za zhi, 74(2), 77-79, 125.

Point mutation of K-ras gene in pancreatic carcinoma. / Huang, Y. T.; Yang, Y. M.; Liu, Qiang.

In: Zhonghua yi xue za zhi, Vol. 74, No. 2, 02.1994, p. 77-79, 125.

Research output: Contribution to journalArticle

Huang, YT, Yang, YM & Liu, Q 1994, 'Point mutation of K-ras gene in pancreatic carcinoma', Zhonghua yi xue za zhi, vol. 74, no. 2, pp. 77-79, 125.
Huang, Y. T. ; Yang, Y. M. ; Liu, Qiang. / Point mutation of K-ras gene in pancreatic carcinoma. In: Zhonghua yi xue za zhi. 1994 ; Vol. 74, No. 2. pp. 77-79, 125.
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