Point mutation of K-ras gene in pancreatic carcinoma

Y. T. Huang, Y. M. Yang, Q. Liu

Research output: Contribution to journalArticlepeer-review


Direct sequencing using Taq enzyme was established for determination of point mutation of K-ras gene at codon 12 in 9 wax samples of pancreatic carcinoma (PC) and 1 of islet cell tumor. Point mutation occurred in 5 of 9 samples of PC and manifested two types of mutation, CCA-->CGA in 4 and CCA-->CAA in 1. The changes of amino acid included changes of glycine to alanine and glycine to valine. The causes of mutation frequency and the content differed from that of foreign reports were analysed in addition to the significance of determining point mutation of K-ras gene at codon 12.

Original languageEnglish (US)
Pages (from-to)77-79, 125-126
JournalZhonghua yi xue za zhi
Issue number2
StatePublished - Feb 1994
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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