TY - JOUR
T1 - Pneumocystis carinii choroidopathy
T2 - A new clinical entity
AU - Freeman, William R.
AU - Gross, Jeffrey G.
AU - Katz, Barrett
AU - Labelle, James
AU - Oteken, Karen
AU - Wiley, Clayton A.
PY - 1989/6
Y1 - 1989/6
N2 - A 43-year-old black woman with acquired immunodeficiency syndrome developed bilateral multifocal choroidopathy characterized by slowly enlarging round to oval lesions in the posterior pole and midperiphery. Systemic evaluation revealed no evidence of mycobacterial, fungal, or spirochetal disease. Fluorescein angiography of the lesions showed early hypofluorescence with late staining of the lesions, which appeared deep to the retinal circulation. There was no evidence of retinal involvement. Over a 4-month period of observation, the lesions appeared to enlarge slowly, with no evidence of vitreous cells or debris in the overlying retina. A transscleral choroidal biopsy was performed, and electron microscopy showed numerous cystic structures characteristic of Pneumocystis carinii within necrotic choroid. The lack of inflammatory changes clinically, by fluorescein angiography, and histopathologically was striking.
AB - A 43-year-old black woman with acquired immunodeficiency syndrome developed bilateral multifocal choroidopathy characterized by slowly enlarging round to oval lesions in the posterior pole and midperiphery. Systemic evaluation revealed no evidence of mycobacterial, fungal, or spirochetal disease. Fluorescein angiography of the lesions showed early hypofluorescence with late staining of the lesions, which appeared deep to the retinal circulation. There was no evidence of retinal involvement. Over a 4-month period of observation, the lesions appeared to enlarge slowly, with no evidence of vitreous cells or debris in the overlying retina. A transscleral choroidal biopsy was performed, and electron microscopy showed numerous cystic structures characteristic of Pneumocystis carinii within necrotic choroid. The lack of inflammatory changes clinically, by fluorescein angiography, and histopathologically was striking.
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U2 - 10.1001/archopht.1989.01070010885036
DO - 10.1001/archopht.1989.01070010885036
M3 - Article
C2 - 2786409
AN - SCOPUS:0024371267
SN - 0003-9950
VL - 107
SP - 863
EP - 867
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 6
ER -