Platelet count and total and cause-specific mortality in the Women's Health Initiative

Geoffrey C. Kabat, Mimi Kim, Amit K. Verma, Jo Ann E Manson, Juan Lin, Lawrence Lessin, Sylvia Wassertheil-Smoller, Thomas E. Rohan

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Abstract

Purpose: We used data from the Women's Health Initiative to examine the association of platelet count with total mortality, coronary heart disease (CHD) mortality, cancer mortality, and non-CHD/noncancer mortality. Methods: Platelet count was measured at baseline in 159,746 postmenopausal women and again in year 3 in 75,339 participants. Participants were followed for a median of 15.9 years. Cox proportional hazards models were used to estimate the relative mortality hazards associated with deciles of baseline platelet count and of the mean of baseline + year 3 platelet count. Results: Low and high deciles of both baseline and mean platelet count were positively associated with total mortality, CHD mortality, cancer mortality, and non-CHD/noncancer mortality. The association was robust and was not affected by adjustment for a number of potential confounding factors, exclusion of women with comorbidity, or allowance for reverse causality. Low- and high-platelet counts were associated with all four outcomes in never smokers, former smokers, and current smokers. Conclusions: In this large study of postmenopausal women, both low- and high-platelet counts were associated with total and cause-specific mortality.

Original languageEnglish (US)
JournalAnnals of Epidemiology
DOIs
StateAccepted/In press - Sep 23 2016

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Keywords

  • Cause-specific mortality
  • Platelet count
  • Postmenopausal women
  • Total mortality

ASJC Scopus subject areas

  • Epidemiology

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