Platelet Activity in Pathogenesis of Atherosclerosis

Edward R. Burns, Robert J. Friedman, Melvin L. Tiell, Theodore H. Spaet, Michael B. Stemerman, Russell Ross, John Glomset

Research output: Contribution to journalLetter

3 Citations (Scopus)

Abstract

To the Editor: Ross and Glomset are to be congratulated for their extensive review emphasizing “the importance of smooth-muscle cell proliferation as a key event” in the pathogenesis of atherosclerosis.1Since they have kindly cited the work of our laboratory, we should like to report the most recent fruits of our investigations. The authors argue that platelet-derived serum factors are responsible for stimulating intimal cell proliferation after endothelial injury. Although we have confirmed the importance of platelets in the “injury-arteriosclerosis” schema, we have demonstrated that their role is limited. Whereas platelet factors are capable of initiating smooth-muscle cell mitosis. . .

Original languageEnglish (US)
Pages (from-to)1199-1200
Number of pages2
JournalNew England Journal of Medicine
Volume295
Issue number21
DOIs
StatePublished - Nov 18 1976

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Atherosclerosis
Blood Platelets
Smooth Muscle Myocytes
Cell Proliferation
Tunica Intima
Arteriosclerosis
Wounds and Injuries
Mitosis
Fruit
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Burns, E. R., Friedman, R. J., Tiell, M. L., Spaet, T. H., Stemerman, M. B., Ross, R., & Glomset, J. (1976). Platelet Activity in Pathogenesis of Atherosclerosis. New England Journal of Medicine, 295(21), 1199-1200. https://doi.org/10.1056/NEJM197611182952116

Platelet Activity in Pathogenesis of Atherosclerosis. / Burns, Edward R.; Friedman, Robert J.; Tiell, Melvin L.; Spaet, Theodore H.; Stemerman, Michael B.; Ross, Russell; Glomset, John.

In: New England Journal of Medicine, Vol. 295, No. 21, 18.11.1976, p. 1199-1200.

Research output: Contribution to journalLetter

Burns, ER, Friedman, RJ, Tiell, ML, Spaet, TH, Stemerman, MB, Ross, R & Glomset, J 1976, 'Platelet Activity in Pathogenesis of Atherosclerosis', New England Journal of Medicine, vol. 295, no. 21, pp. 1199-1200. https://doi.org/10.1056/NEJM197611182952116
Burns ER, Friedman RJ, Tiell ML, Spaet TH, Stemerman MB, Ross R et al. Platelet Activity in Pathogenesis of Atherosclerosis. New England Journal of Medicine. 1976 Nov 18;295(21):1199-1200. https://doi.org/10.1056/NEJM197611182952116
Burns, Edward R. ; Friedman, Robert J. ; Tiell, Melvin L. ; Spaet, Theodore H. ; Stemerman, Michael B. ; Ross, Russell ; Glomset, John. / Platelet Activity in Pathogenesis of Atherosclerosis. In: New England Journal of Medicine. 1976 ; Vol. 295, No. 21. pp. 1199-1200.
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