Plasma profiles of adrenocorticotropic hormone, cortisol, growth hormone and prolactin in patients with untreated parkinson's disease

G. Bellomo, L. Santambrogio, M. Fiacconi, A. M. Scarponi, G. Ciuffetti

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Abstract

Plasma profiles of prolactin, growth hormone, adrenocorticotropic hormone (ACTH) and cortisol were evaluated in a group of untreated patients with idiopathic Parkinson's disease and a group of healthy age-matched controls. Plasma integrated concentrations of all hormones except prolactin were significantly lower in the patients as compared with the controls; however, prolactin nocturnal peak concentration was significantly elevated in the patients; nocturnal growth hormone levels were significantly reduced in the Parkinson group; ACTH and cortisol plasma concentrations were also consistently lower during most of the day in the patients with Parkinson's disease. These data confirm the presence of a hypothalamic disturbance in patients with idopathic Parkinson's disease, which can affect pituitary function.

Original languageEnglish (US)
Pages (from-to)19-22
Number of pages4
JournalJournal of Neurology
Volume238
Issue number1
DOIs
StatePublished - Feb 1 1991

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Keywords

  • Adrenocorticotropic hormone
  • Cortisol
  • Growth hormone
  • Parkinson's disease
  • Prolactin

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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