Plasma levels of tissue plasminogen activator and plasminogen activator inhibitor-1 are correlated with the presence of transplant coronary artery disease in cardiac transplant recipients

Mark K. Warshofsky, Hal S. Wasserman, Weizheng Wang, Peter Teng, Robert Sciacca, Mark Apfelbaum, Allan Schwartz, Robert E. Michler, Donna M. Mancini, Paul J. Cannon, LeRoy E. Rabbani

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Hemostatic factors are involved in the pathogenesis of native coronary artery disease. However, their role in transplant coronary artery disease is less established. To assess the role of hemostatic factors in transplant coronary artery disease we studied 52 consecutive cardiac transplant patients. The presence of transplant coronary artery disease was determined by angiography. Plasma levels of tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAl-1), van Willebrand Factor (vWF), and fibrin D-dimer were determined by enzyme-linked immunosorbent assays. Serum lipids were measured by enzymatic methods. Patients with transplant coronary artery disease had higher circulating t-PA (8.6 ± 0.8 vs. 5.4 ± 0.6 ng/ml, p = 0.021) and PAl-1 antigen concentrations (38.0 ± 3.4 vs 25.8 ± 2.2 ng/ml, p = 0.037). t-PA and PAl-1 antigen concentrations correlated with the severity of angiographic disease (R = 0.34: p = 0.014 far t-PA, and R = 0.45; p = 0.001 for PAl-1). Serum cholesterol levels were higher in patients with transplant coronary artery disease (221 ± 7.6 vs 191 ± 9.2 mg/dl, p = 0.039). Serum triglycerides were also higher in patients with transplant coronary artery disease by angiography (246 ± 38.3 vs 139 ± 20.8 mg/dl, p = 0.050). Multivariate analysis identified t-PA antigen (p = 0.003) and triglyceride levels (p = 0.038) as independent predictors for the presence of transplant coronary artery disease. We conclude that cardiac transplant patients with evidence of transplant coronary artery disease on coronary angiography have altered hemostatic function which is reflected by elevated levels of circulating t-PA and PAl-1 antigens. The interaction of the hemostatic system and serum lipids in the development of transplant coronary artery disease warrants further study.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalAmerican Journal of Cardiology
Volume80
Issue number2
DOIs
StatePublished - Jul 15 1997
Externally publishedYes

Fingerprint

Plasminogen Activator Inhibitor 1
Tissue Plasminogen Activator
Coronary Artery Disease
Transplants
Hemostatics
Antigens
Serum
Angiography
Triglycerides
Transplant Recipients
Lipids
Hypercholesterolemia
Coronary Angiography
Multivariate Analysis
Enzyme-Linked Immunosorbent Assay

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Plasma levels of tissue plasminogen activator and plasminogen activator inhibitor-1 are correlated with the presence of transplant coronary artery disease in cardiac transplant recipients. / Warshofsky, Mark K.; Wasserman, Hal S.; Wang, Weizheng; Teng, Peter; Sciacca, Robert; Apfelbaum, Mark; Schwartz, Allan; Michler, Robert E.; Mancini, Donna M.; Cannon, Paul J.; Rabbani, LeRoy E.

In: American Journal of Cardiology, Vol. 80, No. 2, 15.07.1997, p. 145-149.

Research output: Contribution to journalArticle

Warshofsky, Mark K. ; Wasserman, Hal S. ; Wang, Weizheng ; Teng, Peter ; Sciacca, Robert ; Apfelbaum, Mark ; Schwartz, Allan ; Michler, Robert E. ; Mancini, Donna M. ; Cannon, Paul J. ; Rabbani, LeRoy E. / Plasma levels of tissue plasminogen activator and plasminogen activator inhibitor-1 are correlated with the presence of transplant coronary artery disease in cardiac transplant recipients. In: American Journal of Cardiology. 1997 ; Vol. 80, No. 2. pp. 145-149.
@article{c8c7c106da7a44d0a72c5c6a23c75afd,
title = "Plasma levels of tissue plasminogen activator and plasminogen activator inhibitor-1 are correlated with the presence of transplant coronary artery disease in cardiac transplant recipients",
abstract = "Hemostatic factors are involved in the pathogenesis of native coronary artery disease. However, their role in transplant coronary artery disease is less established. To assess the role of hemostatic factors in transplant coronary artery disease we studied 52 consecutive cardiac transplant patients. The presence of transplant coronary artery disease was determined by angiography. Plasma levels of tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAl-1), van Willebrand Factor (vWF), and fibrin D-dimer were determined by enzyme-linked immunosorbent assays. Serum lipids were measured by enzymatic methods. Patients with transplant coronary artery disease had higher circulating t-PA (8.6 ± 0.8 vs. 5.4 ± 0.6 ng/ml, p = 0.021) and PAl-1 antigen concentrations (38.0 ± 3.4 vs 25.8 ± 2.2 ng/ml, p = 0.037). t-PA and PAl-1 antigen concentrations correlated with the severity of angiographic disease (R = 0.34: p = 0.014 far t-PA, and R = 0.45; p = 0.001 for PAl-1). Serum cholesterol levels were higher in patients with transplant coronary artery disease (221 ± 7.6 vs 191 ± 9.2 mg/dl, p = 0.039). Serum triglycerides were also higher in patients with transplant coronary artery disease by angiography (246 ± 38.3 vs 139 ± 20.8 mg/dl, p = 0.050). Multivariate analysis identified t-PA antigen (p = 0.003) and triglyceride levels (p = 0.038) as independent predictors for the presence of transplant coronary artery disease. We conclude that cardiac transplant patients with evidence of transplant coronary artery disease on coronary angiography have altered hemostatic function which is reflected by elevated levels of circulating t-PA and PAl-1 antigens. The interaction of the hemostatic system and serum lipids in the development of transplant coronary artery disease warrants further study.",
author = "Warshofsky, {Mark K.} and Wasserman, {Hal S.} and Weizheng Wang and Peter Teng and Robert Sciacca and Mark Apfelbaum and Allan Schwartz and Michler, {Robert E.} and Mancini, {Donna M.} and Cannon, {Paul J.} and Rabbani, {LeRoy E.}",
year = "1997",
month = "7",
day = "15",
doi = "10.1016/S0002-9149(97)00308-1",
language = "English (US)",
volume = "80",
pages = "145--149",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Plasma levels of tissue plasminogen activator and plasminogen activator inhibitor-1 are correlated with the presence of transplant coronary artery disease in cardiac transplant recipients

AU - Warshofsky, Mark K.

AU - Wasserman, Hal S.

AU - Wang, Weizheng

AU - Teng, Peter

AU - Sciacca, Robert

AU - Apfelbaum, Mark

AU - Schwartz, Allan

AU - Michler, Robert E.

AU - Mancini, Donna M.

AU - Cannon, Paul J.

AU - Rabbani, LeRoy E.

PY - 1997/7/15

Y1 - 1997/7/15

N2 - Hemostatic factors are involved in the pathogenesis of native coronary artery disease. However, their role in transplant coronary artery disease is less established. To assess the role of hemostatic factors in transplant coronary artery disease we studied 52 consecutive cardiac transplant patients. The presence of transplant coronary artery disease was determined by angiography. Plasma levels of tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAl-1), van Willebrand Factor (vWF), and fibrin D-dimer were determined by enzyme-linked immunosorbent assays. Serum lipids were measured by enzymatic methods. Patients with transplant coronary artery disease had higher circulating t-PA (8.6 ± 0.8 vs. 5.4 ± 0.6 ng/ml, p = 0.021) and PAl-1 antigen concentrations (38.0 ± 3.4 vs 25.8 ± 2.2 ng/ml, p = 0.037). t-PA and PAl-1 antigen concentrations correlated with the severity of angiographic disease (R = 0.34: p = 0.014 far t-PA, and R = 0.45; p = 0.001 for PAl-1). Serum cholesterol levels were higher in patients with transplant coronary artery disease (221 ± 7.6 vs 191 ± 9.2 mg/dl, p = 0.039). Serum triglycerides were also higher in patients with transplant coronary artery disease by angiography (246 ± 38.3 vs 139 ± 20.8 mg/dl, p = 0.050). Multivariate analysis identified t-PA antigen (p = 0.003) and triglyceride levels (p = 0.038) as independent predictors for the presence of transplant coronary artery disease. We conclude that cardiac transplant patients with evidence of transplant coronary artery disease on coronary angiography have altered hemostatic function which is reflected by elevated levels of circulating t-PA and PAl-1 antigens. The interaction of the hemostatic system and serum lipids in the development of transplant coronary artery disease warrants further study.

AB - Hemostatic factors are involved in the pathogenesis of native coronary artery disease. However, their role in transplant coronary artery disease is less established. To assess the role of hemostatic factors in transplant coronary artery disease we studied 52 consecutive cardiac transplant patients. The presence of transplant coronary artery disease was determined by angiography. Plasma levels of tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAl-1), van Willebrand Factor (vWF), and fibrin D-dimer were determined by enzyme-linked immunosorbent assays. Serum lipids were measured by enzymatic methods. Patients with transplant coronary artery disease had higher circulating t-PA (8.6 ± 0.8 vs. 5.4 ± 0.6 ng/ml, p = 0.021) and PAl-1 antigen concentrations (38.0 ± 3.4 vs 25.8 ± 2.2 ng/ml, p = 0.037). t-PA and PAl-1 antigen concentrations correlated with the severity of angiographic disease (R = 0.34: p = 0.014 far t-PA, and R = 0.45; p = 0.001 for PAl-1). Serum cholesterol levels were higher in patients with transplant coronary artery disease (221 ± 7.6 vs 191 ± 9.2 mg/dl, p = 0.039). Serum triglycerides were also higher in patients with transplant coronary artery disease by angiography (246 ± 38.3 vs 139 ± 20.8 mg/dl, p = 0.050). Multivariate analysis identified t-PA antigen (p = 0.003) and triglyceride levels (p = 0.038) as independent predictors for the presence of transplant coronary artery disease. We conclude that cardiac transplant patients with evidence of transplant coronary artery disease on coronary angiography have altered hemostatic function which is reflected by elevated levels of circulating t-PA and PAl-1 antigens. The interaction of the hemostatic system and serum lipids in the development of transplant coronary artery disease warrants further study.

UR - http://www.scopus.com/inward/record.url?scp=17644435391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17644435391&partnerID=8YFLogxK

U2 - 10.1016/S0002-9149(97)00308-1

DO - 10.1016/S0002-9149(97)00308-1

M3 - Article

VL - 80

SP - 145

EP - 149

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 2

ER -