Plasma levels of provitamin A and non-provitamin A carotenoids, retinol, and tocopherols in gynecologic cancers

P. R. Palan, G. L. Goldberg, C. D. Runowicz, S. L. Romney

Research output: Contribution to journalArticle

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Abstract

There is strong evidence for an etiologic role of dietary nutrition, particularly anti-oxidant micronutrients in the oncogenesis and prevention of certain cancers. In the present study, we measured the plasma levels of selected provitamin A and non-provitamin A carotenoids, retinol and a-tocopherol and gammatocopherol by reversed-phase high-pressure liquid chromatography in patients with histopathologically confirmed gynecologic cancers (n=38) and in normal volunteer women with no known gynecologic pathology (n=53). The mean plasma β-carotene, lycopene, canthaxanthin and a-tocopherol levels were significantly (p <0.012, p <0.004, p <0.007, and p <0.001, respectively, by ANOVA) lower in patients with carcinoma of the cervix, endometrium or ovary compared with the mean plasma levels in controls. However, the mean plasma gamma-tocopherol level was significantly lower (p <0.05) only in ovarian cancer patients and the plasma retinol levels were comparable among all subjects. These findings suggest that selected micronutrients may be acting as antioxidant to quench and protect against free radical-induced carcinogenic gene mutations in human gynecologic carcinomas. Further studies of the role(s) of these antioxidant vitamins at the molecular level are required.

Original languageEnglish (US)
Pages (from-to)157-161
Number of pages5
JournalMedecine Biologie Environnement
Volume23
Issue number2
StatePublished - 1995

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Tocopherols
Carotenoids
Vitamin A
Plasmas
Micronutrients
Neoplasms
Antioxidants
Canthaxanthin
High pressure liquid chromatography
gamma-Tocopherol
Pathology
Reverse-Phase Chromatography
Endometrial Neoplasms
Nutrition
Analysis of variance (ANOVA)
Oxidants
Cervix Uteri
Vitamins
Ovarian Neoplasms
Free Radicals

Keywords

  • Antioxidants
  • Carotenoids
  • Gynecologic cancers
  • Nutrients
  • Tocopherols

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Plasma levels of provitamin A and non-provitamin A carotenoids, retinol, and tocopherols in gynecologic cancers. / Palan, P. R.; Goldberg, G. L.; Runowicz, C. D.; Romney, S. L.

In: Medecine Biologie Environnement, Vol. 23, No. 2, 1995, p. 157-161.

Research output: Contribution to journalArticle

Palan, P. R. ; Goldberg, G. L. ; Runowicz, C. D. ; Romney, S. L. / Plasma levels of provitamin A and non-provitamin A carotenoids, retinol, and tocopherols in gynecologic cancers. In: Medecine Biologie Environnement. 1995 ; Vol. 23, No. 2. pp. 157-161.
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