Plasma human immunodeficiency virus (HIV) type 1 RNA load in men and women with advanced HIV-1 disease

The Viral Activation Transfusion Study Group

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Several studies of patients infected with human immunodeficiency virus (HIV) type 1 have suggested that women have lower plasma HIV-1 RNA levels than men, even when controlling for CD4 T cell levels. A cross-sectional analysis was performed in 494 patients (21% of whom were women) who enrolled in a prospective study of anemic HIV-1-infected patients requiring transfusion. The median CD4 T cell count and plasma HIV-1 RNA levels were 15 cells/μL and 4.83 log10 copies/mL (67,350 copies/mL), respectively. In unadjusted analyses, women had slightly higher mean log HIV-1 RNA titers than men (0.19 log10 higher copies/mL; 95% confidence interval, -0.05 to 0.44; P = .11). Adjustment for CD4 T cell count, race or ethnicity, injection drug use, and age yielded a smaller sex difference (0.13 log10 copies/mL higher in women; P = .28). In this population of patients with very advanced HIV disease, there is no evidence that women have lower HIV-1 RNA levels than men.

Original languageEnglish (US)
Pages (from-to)603-606
Number of pages4
JournalJournal of Infectious Diseases
Volume182
Issue number2
DOIs
StatePublished - 2000
Externally publishedYes

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Virus Diseases
HIV-1
RNA
CD4 Lymphocyte Count
T-Lymphocytes
Sex Characteristics
Cross-Sectional Studies
HIV
Prospective Studies
Confidence Intervals
Injections
Pharmaceutical Preparations
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Plasma human immunodeficiency virus (HIV) type 1 RNA load in men and women with advanced HIV-1 disease. / The Viral Activation Transfusion Study Group.

In: Journal of Infectious Diseases, Vol. 182, No. 2, 2000, p. 603-606.

Research output: Contribution to journalArticle

The Viral Activation Transfusion Study Group. / Plasma human immunodeficiency virus (HIV) type 1 RNA load in men and women with advanced HIV-1 disease. In: Journal of Infectious Diseases. 2000 ; Vol. 182, No. 2. pp. 603-606.
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abstract = "Several studies of patients infected with human immunodeficiency virus (HIV) type 1 have suggested that women have lower plasma HIV-1 RNA levels than men, even when controlling for CD4 T cell levels. A cross-sectional analysis was performed in 494 patients (21{\%} of whom were women) who enrolled in a prospective study of anemic HIV-1-infected patients requiring transfusion. The median CD4 T cell count and plasma HIV-1 RNA levels were 15 cells/μL and 4.83 log10 copies/mL (67,350 copies/mL), respectively. In unadjusted analyses, women had slightly higher mean log HIV-1 RNA titers than men (0.19 log10 higher copies/mL; 95{\%} confidence interval, -0.05 to 0.44; P = .11). Adjustment for CD4 T cell count, race or ethnicity, injection drug use, and age yielded a smaller sex difference (0.13 log10 copies/mL higher in women; P = .28). In this population of patients with very advanced HIV disease, there is no evidence that women have lower HIV-1 RNA levels than men.",
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