Abstract
Several studies of patients infected with human immunodeficiency virus (HIV) type 1 have suggested that women have lower plasma HIV-1 RNA levels than men, even when controlling for CD4 T cell levels. A cross-sectional analysis was performed in 494 patients (21% of whom were women) who enrolled in a prospective study of anemic HIV-1-infected patients requiring transfusion. The median CD4 T cell count and plasma HIV-1 RNA levels were 15 cells/μL and 4.83 log10 copies/mL (67,350 copies/mL), respectively. In unadjusted analyses, women had slightly higher mean log HIV-1 RNA titers than men (0.19 log10 higher copies/mL; 95% confidence interval, -0.05 to 0.44; P = .11). Adjustment for CD4 T cell count, race or ethnicity, injection drug use, and age yielded a smaller sex difference (0.13 log10 copies/mL higher in women; P = .28). In this population of patients with very advanced HIV disease, there is no evidence that women have lower HIV-1 RNA levels than men.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 603-606 |
| Number of pages | 4 |
| Journal | Journal of Infectious Diseases |
| Volume | 182 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
Cite this
Plasma human immunodeficiency virus (HIV) type 1 RNA load in men and women with advanced HIV-1 disease. / The Viral Activation Transfusion Study Group.
In: Journal of Infectious Diseases, Vol. 182, No. 2, 2000, p. 603-606.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma human immunodeficiency virus (HIV) type 1 RNA load in men and women with advanced HIV-1 disease
AU - The Viral Activation Transfusion Study Group
AU - Kalish, Leslie
AU - Collier, Ann C.
AU - Flanigan, Timothy P.
AU - Kumar, Princy N.
AU - Lederman, Michael
AU - Yomtovian, Roslyn
AU - Chance, Michael
AU - Hendrix, Donna
AU - Kumar, Princy N.
AU - Sandler, S. Gerald
AU - Hawkins, Karyn
AU - Flanigan, Timothy P.
AU - Sweeney, Joseph
AU - Mileno, Maria D.
AU - Spigno, Melissa Di
AU - Dupuis, Michelle
AU - Sacks, Henry S.
AU - Mohandas, Kala
AU - Wallach, Frances R.
AU - Mintz, Letty
AU - Para, Michael F.
AU - Kennedy, Melanie S.
AU - Russell, Jane
AU - Krugh, Dave
AU - Lane, Thomas A.
AU - Mathews, W. Christopher
AU - Mollen-Rabwin, Peggy
AU - van der Horst, Charles
AU - Kelley, Meera
AU - Brecher, Mark E.
AU - Ngo, Linh
AU - Mellors, John W.
AU - Triulzi, Darrell J.
AU - Mc Mahon, Deborah K.
AU - Riddler, Sharon
AU - Asmuth, David M.
AU - Curry, Janice
AU - Shulman, Gerald
AU - Ann, Collier
AU - Gernsheimer, Terry
AU - Townsend-Mc Call, Dee
AU - Corson, Jill
AU - Busch, Michael P.
AU - Lee, Tzong Hae
AU - Drew, W. Lawrence
AU - Laycock, Megan
AU - Kalish, Leslie A.
AU - Ass-Mann, Susan F.
AU - Carrington, Jane D.
AU - Kruskall, Margot S.
PY - 2000
Y1 - 2000
N2 - Several studies of patients infected with human immunodeficiency virus (HIV) type 1 have suggested that women have lower plasma HIV-1 RNA levels than men, even when controlling for CD4 T cell levels. A cross-sectional analysis was performed in 494 patients (21% of whom were women) who enrolled in a prospective study of anemic HIV-1-infected patients requiring transfusion. The median CD4 T cell count and plasma HIV-1 RNA levels were 15 cells/μL and 4.83 log10 copies/mL (67,350 copies/mL), respectively. In unadjusted analyses, women had slightly higher mean log HIV-1 RNA titers than men (0.19 log10 higher copies/mL; 95% confidence interval, -0.05 to 0.44; P = .11). Adjustment for CD4 T cell count, race or ethnicity, injection drug use, and age yielded a smaller sex difference (0.13 log10 copies/mL higher in women; P = .28). In this population of patients with very advanced HIV disease, there is no evidence that women have lower HIV-1 RNA levels than men.
AB - Several studies of patients infected with human immunodeficiency virus (HIV) type 1 have suggested that women have lower plasma HIV-1 RNA levels than men, even when controlling for CD4 T cell levels. A cross-sectional analysis was performed in 494 patients (21% of whom were women) who enrolled in a prospective study of anemic HIV-1-infected patients requiring transfusion. The median CD4 T cell count and plasma HIV-1 RNA levels were 15 cells/μL and 4.83 log10 copies/mL (67,350 copies/mL), respectively. In unadjusted analyses, women had slightly higher mean log HIV-1 RNA titers than men (0.19 log10 higher copies/mL; 95% confidence interval, -0.05 to 0.44; P = .11). Adjustment for CD4 T cell count, race or ethnicity, injection drug use, and age yielded a smaller sex difference (0.13 log10 copies/mL higher in women; P = .28). In this population of patients with very advanced HIV disease, there is no evidence that women have lower HIV-1 RNA levels than men.
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U2 - 10.1086/315710
DO - 10.1086/315710
M3 - Article
VL - 182
SP - 603
EP - 606
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 2
ER -