@article{18e51b6568634d11b4c3a6f7479ef190,
title = "Plasma human immunodeficiency virus (HIV) type 1 RNA load in men and women with advanced HIV-1 disease",
abstract = "Several studies of patients infected with human immunodeficiency virus (HIV) type 1 have suggested that women have lower plasma HIV-1 RNA levels than men, even when controlling for CD4 T cell levels. A cross-sectional analysis was performed in 494 patients (21% of whom were women) who enrolled in a prospective study of anemic HIV-1-infected patients requiring transfusion. The median CD4 T cell count and plasma HIV-1 RNA levels were 15 cells/μL and 4.83 log10 copies/mL (67,350 copies/mL), respectively. In unadjusted analyses, women had slightly higher mean log HIV-1 RNA titers than men (0.19 log10 higher copies/mL; 95% confidence interval, -0.05 to 0.44; P = .11). Adjustment for CD4 T cell count, race or ethnicity, injection drug use, and age yielded a smaller sex difference (0.13 log10 copies/mL higher in women; P = .28). In this population of patients with very advanced HIV disease, there is no evidence that women have lower HIV-1 RNA levels than men.",
author = "{The Viral Activation Transfusion Study Group} and Leslie Kalish and Collier, {Ann C.} and Flanigan, {Timothy P.} and Kumar, {Princy N.} and Michael Lederman and Roslyn Yomtovian and Michael Chance and Donna Hendrix and Kumar, {Princy N.} and Sandler, {S. Gerald} and Karyn Hawkins and Flanigan, {Timothy P.} and Joseph Sweeney and Mileno, {Maria D.} and Spigno, {Melissa Di} and Michelle Dupuis and Sacks, {Henry S.} and Kala Mohandas and Wallach, {Frances R.} and Letty Mintz and Para, {Michael F.} and Kennedy, {Melanie S.} and Jane Russell and Dave Krugh and Lane, {Thomas A.} and Mathews, {W. Christopher} and Peggy Mollen-Rabwin and {van der Horst}, Charles and Meera Kelley and Brecher, {Mark E.} and Linh Ngo and Mellors, {John W.} and Triulzi, {Darrell J.} and {Mc Mahon}, {Deborah K.} and Sharon Riddler and Asmuth, {David M.} and Janice Curry and Gerald Shulman and Collier Ann and Terry Gernsheimer and {Townsend-Mc Call}, Dee and Jill Corson and Busch, {Michael P.} and Lee, {Tzong Hae} and Drew, {W. Lawrence} and Megan Laycock and Kalish, {Leslie A.} and Ass-Mann, {Susan F.} and Carrington, {Jane D.} and Kruskall, {Margot S.}",
note = "Funding Information: Financial support: Viral Activation Transfusion Study Group of the National Heart, Lung, and Blood Institute, National Institutes of Health (contracts N01-HB-57115, N01-HB-57116, N01-HB-57117, N01-HB-57118, N01-HB-57119, N01-HB-57120, N01-HB-57121, N01-HB-57122, N01-HB-57123, N01-HB-57124, N01-HB-57125, N01-HB-57126, and N01-HB-57127). a Members of the study group are listed after the text.",
year = "2000",
doi = "10.1086/315710",
language = "English (US)",
volume = "182",
pages = "603--606",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",
}