Plasma homocysteine is not associated with HIV serostatus or antiretroviral therapy in women

Farbod Raiszadeh, Donald R. Hoover, Irene Lee, Qiuhu Shi, Kathryn Anastos, Wei Gao, Robert C. Kaplan, Marshall J. Glesby

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BACKGROUND: The effects of HIV serostatus and combination antiretroviral therapy (cART) on plasma homocysteine (HCY) are uncertain. METHODS: Plasma HCY was assayed in a cross-sectional study of 249 HIV-infected and 127 HIV-uninfected women at the Bronx Women's Interagency HIV Study site. RESULTS: Mean plasma HCY was 7.42 ± 2.68 in HIV-infected women and 7.18 ± 2.66 μmol/L in HIV-uninfected women (P = 0.40). Hyperhomocysteinemia (defined as HCY >10 μmol/L) was seen in 16.9% and 13.4% of HIV-infected and HIV-uninfected women, respectively (P = 0.45). Among HIV-infected women, cART use was not associated with HCY level. Compared with the lowest quartile, women with HCY in the highest quartile had lower mean serum vitamin B12 and RBC folate levels. In multivariate analysis that did not include micronutrient levels, age, serum creatinine, and lower CD4% were significantly associated with plasma HCY level in HIV-infected women. CONCLUSIONS: Plasma HCY was not associated with HIV serostatus or use of cART in this cross-sectional study. Reduced availability of folate cofactors for HCY remethylation in HIV-infected women with lower folate intake and decreased health status may influence HCY levels.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume51
Issue number2
DOIs
StatePublished - Jun 2009

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Homocysteine
HIV
Therapeutics
Folic Acid
Cross-Sectional Studies
Hyperhomocysteinemia
Micronutrients
Vitamin B 12
Serum
Health Status
Creatinine
Multivariate Analysis

Keywords

  • Folate
  • HIV
  • Homocysteine
  • Vitamin B12
  • Women

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Plasma homocysteine is not associated with HIV serostatus or antiretroviral therapy in women. / Raiszadeh, Farbod; Hoover, Donald R.; Lee, Irene; Shi, Qiuhu; Anastos, Kathryn; Gao, Wei; Kaplan, Robert C.; Glesby, Marshall J.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 51, No. 2, 06.2009, p. 175-178.

Research output: Contribution to journalArticle

Raiszadeh, Farbod ; Hoover, Donald R. ; Lee, Irene ; Shi, Qiuhu ; Anastos, Kathryn ; Gao, Wei ; Kaplan, Robert C. ; Glesby, Marshall J. / Plasma homocysteine is not associated with HIV serostatus or antiretroviral therapy in women. In: Journal of Acquired Immune Deficiency Syndromes. 2009 ; Vol. 51, No. 2. pp. 175-178.
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abstract = "BACKGROUND: The effects of HIV serostatus and combination antiretroviral therapy (cART) on plasma homocysteine (HCY) are uncertain. METHODS: Plasma HCY was assayed in a cross-sectional study of 249 HIV-infected and 127 HIV-uninfected women at the Bronx Women's Interagency HIV Study site. RESULTS: Mean plasma HCY was 7.42 ± 2.68 in HIV-infected women and 7.18 ± 2.66 μmol/L in HIV-uninfected women (P = 0.40). Hyperhomocysteinemia (defined as HCY >10 μmol/L) was seen in 16.9{\%} and 13.4{\%} of HIV-infected and HIV-uninfected women, respectively (P = 0.45). Among HIV-infected women, cART use was not associated with HCY level. Compared with the lowest quartile, women with HCY in the highest quartile had lower mean serum vitamin B12 and RBC folate levels. In multivariate analysis that did not include micronutrient levels, age, serum creatinine, and lower CD4{\%} were significantly associated with plasma HCY level in HIV-infected women. CONCLUSIONS: Plasma HCY was not associated with HIV serostatus or use of cART in this cross-sectional study. Reduced availability of folate cofactors for HCY remethylation in HIV-infected women with lower folate intake and decreased health status may influence HCY levels.",
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