PKD1 inhibits cancer cells migration and invasion via Wnt signaling pathway in vitro

Ke Zhang; Chun Ye; Qin Zhou; Rong Zheng; Xiaoyan Lv; Ye Chen; Zhongguo Hu; Hong Guo; Zheng Zhang; Yidong Wang; Ruizhi Tan; Yuhang Liu

doi:10.1002/cbf.1417

PKD1 inhibits cancer cells migration and invasion via Wnt signaling pathway in vitro

Ke Zhang, Chun Ye, Qin Zhou, Rong Zheng, Xiaoyan Lv, Ye Chen, Zhongguo Hu, Hong Guo, Zheng Zhang, Yidong Wang, Ruizhi Tan, Yuhang Liu

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The ∼14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a large (∼460 kDa) protein, termed polycystin-1 (PC-1), that is responsible for autosomal dominant polycystic kidney disease (ADPKD). The unique organization of its multiple adhesive domains (16 Ig-like domains/PKD domains) suggests that it may play an important role in cell-cell/cell-matrix interactions. Here we demonstrated that PKD1 promoted cell-cell and cell-matrix interactions in cancer cells, indicating that PC-1 is involved in the cell adhesion process. Furthermore in this study, we showed that PKD1 inhibited cancer cells migration and invasion. And we also showed that PC-1 regulated these processes in a process that may be at least partially through the Wnt pathway. Collectively, our data suggest that PKD1 may act as a novel member of the tumor suppressor family of genes.

Original language	English (US)
Pages (from-to)	767-774
Number of pages	8
Journal	Cell Biochemistry and Function
Volume	25
Issue number	6
DOIs	https://doi.org/10.1002/cbf.1417
State	Published - Nov 2007
Externally published	Yes

Keywords

Cell migration
Invasion
PKD1 gene
Wnt signaling pathway

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/cbf.1417

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title = "PKD1 inhibits cancer cells migration and invasion via Wnt signaling pathway in vitro",

abstract = "The ∼14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a large (∼460 kDa) protein, termed polycystin-1 (PC-1), that is responsible for autosomal dominant polycystic kidney disease (ADPKD). The unique organization of its multiple adhesive domains (16 Ig-like domains/PKD domains) suggests that it may play an important role in cell-cell/cell-matrix interactions. Here we demonstrated that PKD1 promoted cell-cell and cell-matrix interactions in cancer cells, indicating that PC-1 is involved in the cell adhesion process. Furthermore in this study, we showed that PKD1 inhibited cancer cells migration and invasion. And we also showed that PC-1 regulated these processes in a process that may be at least partially through the Wnt pathway. Collectively, our data suggest that PKD1 may act as a novel member of the tumor suppressor family of genes.",

keywords = "Cell migration, Invasion, PKD1 gene, Wnt signaling pathway",

author = "Ke Zhang and Chun Ye and Qin Zhou and Rong Zheng and Xiaoyan Lv and Ye Chen and Zhongguo Hu and Hong Guo and Zheng Zhang and Yidong Wang and Ruizhi Tan and Yuhang Liu",

year = "2007",

month = nov,

doi = "10.1002/cbf.1417",

language = "English (US)",

volume = "25",

pages = "767--774",

journal = "Cell Biochemistry and Function",

issn = "0263-6484",

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TY - JOUR

T1 - PKD1 inhibits cancer cells migration and invasion via Wnt signaling pathway in vitro

AU - Zhang, Ke

AU - Ye, Chun

AU - Zhou, Qin

AU - Zheng, Rong

AU - Lv, Xiaoyan

AU - Chen, Ye

AU - Hu, Zhongguo

AU - Guo, Hong

AU - Zhang, Zheng

AU - Wang, Yidong

AU - Tan, Ruizhi

AU - Liu, Yuhang

PY - 2007/11

Y1 - 2007/11

N2 - The ∼14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a large (∼460 kDa) protein, termed polycystin-1 (PC-1), that is responsible for autosomal dominant polycystic kidney disease (ADPKD). The unique organization of its multiple adhesive domains (16 Ig-like domains/PKD domains) suggests that it may play an important role in cell-cell/cell-matrix interactions. Here we demonstrated that PKD1 promoted cell-cell and cell-matrix interactions in cancer cells, indicating that PC-1 is involved in the cell adhesion process. Furthermore in this study, we showed that PKD1 inhibited cancer cells migration and invasion. And we also showed that PC-1 regulated these processes in a process that may be at least partially through the Wnt pathway. Collectively, our data suggest that PKD1 may act as a novel member of the tumor suppressor family of genes.

AB - The ∼14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a large (∼460 kDa) protein, termed polycystin-1 (PC-1), that is responsible for autosomal dominant polycystic kidney disease (ADPKD). The unique organization of its multiple adhesive domains (16 Ig-like domains/PKD domains) suggests that it may play an important role in cell-cell/cell-matrix interactions. Here we demonstrated that PKD1 promoted cell-cell and cell-matrix interactions in cancer cells, indicating that PC-1 is involved in the cell adhesion process. Furthermore in this study, we showed that PKD1 inhibited cancer cells migration and invasion. And we also showed that PC-1 regulated these processes in a process that may be at least partially through the Wnt pathway. Collectively, our data suggest that PKD1 may act as a novel member of the tumor suppressor family of genes.

KW - Cell migration

KW - Invasion

KW - PKD1 gene

KW - Wnt signaling pathway

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DO - 10.1002/cbf.1417

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SN - 0263-6484

VL - 25

SP - 767

EP - 774

JO - Cell Biochemistry and Function

JF - Cell Biochemistry and Function

IS - 6

ER -

PKD1 inhibits cancer cells migration and invasion via Wnt signaling pathway in vitro

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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