PKD1 inhibits cancer cells migration and invasion via Wnt signaling pathway in vitro

Ke Zhang, Chun Ye, Qin Zhou, Rong Zheng, Xiaoyan Lv, Ye Chen, Zhongguo Hu, Hong Guo, Zheng Zhang, Yidong Wang, Ruizhi Tan, Yuhang Liu

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

The ∼14 kb mRNA of the polycystic kidney disease gene PKD1 encodes a large (∼460 kDa) protein, termed polycystin-1 (PC-1), that is responsible for autosomal dominant polycystic kidney disease (ADPKD). The unique organization of its multiple adhesive domains (16 Ig-like domains/PKD domains) suggests that it may play an important role in cell-cell/cell-matrix interactions. Here we demonstrated that PKD1 promoted cell-cell and cell-matrix interactions in cancer cells, indicating that PC-1 is involved in the cell adhesion process. Furthermore in this study, we showed that PKD1 inhibited cancer cells migration and invasion. And we also showed that PC-1 regulated these processes in a process that may be at least partially through the Wnt pathway. Collectively, our data suggest that PKD1 may act as a novel member of the tumor suppressor family of genes.

Original languageEnglish (US)
Pages (from-to)767-774
Number of pages8
JournalCell Biochemistry and Function
Volume25
Issue number6
DOIs
Publication statusPublished - Nov 1 2007

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Keywords

  • Cell migration
  • Invasion
  • PKD1 gene
  • Wnt signaling pathway

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Cell Biology

Cite this

Zhang, K., Ye, C., Zhou, Q., Zheng, R., Lv, X., Chen, Y., ... Liu, Y. (2007). PKD1 inhibits cancer cells migration and invasion via Wnt signaling pathway in vitro. Cell Biochemistry and Function, 25(6), 767-774. https://doi.org/10.1002/cbf.1417