@article{6421753dcfad417eb322cd80fe2f8bca,
title = "PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression",
abstract = "Yotaro et al. define a tumor suppressor role for PKCλ/ι in hepatocellular carcinoma (HCC). PKCλ/ι loss induces oxidative phosphorylation, reactive oxygen species production, and autophagy. These events activate an NRF2 transcriptional program that supports HCC progression.",
keywords = "NRF2, PKCζ, PKCι, PKCλ, atypical PKC, autophagy, hepatocellular carcinoma, metabolic reprogramming, oxidative phosphorylation, reactive oxygen species",
author = "Yotaro Kudo and Masayuki Sugimoto and Esperanza Arias and Hiroaki Kasashima and Thekla Cordes and Linares, {Juan F.} and Angeles Duran and Yuki Nakanishi and Naoko Nakanishi and Antoine L'Hermitte and Alex Campos and Nadia Senni and Tarmo Rooslid and Roberts, {Lewis R.} and Cuervo, {Ana Maria} and Metallo, {Christian M.} and Michael Karin and Diaz-Meco, {Maria T.} and Jorge Moscat",
note = "Funding Information: Research was supported by grants by NCI and NIDDK of the NIH under awards numbers: R01DK108743 , R01CA211794 to J.M.; R01CA218254 to M.T.D.-M.; CA211794 and CA234128 to M.K.; and R01CA234245 to C.M.M. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. We thank the personnel of the Histology, Flow Cytometry, Proteomics, Cell Imaging, Genomics, Animal Facility, and Viral Vectors Shared Resources at SBP Medical Discovery Institute for technical assistance. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = aug,
day = "10",
doi = "10.1016/j.ccell.2020.05.018",
language = "English (US)",
volume = "38",
pages = "247--262.e11",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "2",
}
